[starmanj]

Experience with daratumumab vs. elotuzumab vs. SAR650984?

by starmanj on Sun Jul 21, 2013 2:59 pm

My wife has had Myeloma since 2003. She is now refractory from thalidomide, Rev, Pom, Velcade and Carfilzomib. She is taking very high dose combo Rev/Vel but it's making her too sick to continue.

SO...that leaves us needing to get a novel therapy via trial. The MABs don't hit the same target as the other two main lines (iMids and Proteasome Inhibitors) so promises durability and most effective way to go.

There are no trials in our state so we have to relocate. We have to get this right the first time, so...

Any expert opinion on which of the above MABs are the most effective and lowest side effect? I hear SAR650984 is very early and really wallops you during infusion. Is anybody taking daratumumab at Dana Farber? Anybody taken elotuzumab? Your experiences?

We both would really appreciate any feedback!!
Starmanj

[tij2002]

Re: Experience with daratumumab vs. elotuzumab vs. SAR650984

by tij2002 on Fri Sep 06, 2013 5:18 pm

Also wonder if anyone had experience with Daratumumab or SAR650984. Thank you in advance for sharing.

[Dr. Ken Shain]

Re: Experience with daratumumab vs. elotuzumab vs. SAR650984

by Dr. Ken Shain on Sat Sep 07, 2013 6:26 pm

I feel that these new antibody therapies represent an exciting new class of therapeutics in myeloma. They are all generally well tolerated with appropriate pre-medication. Our experience at Moffitt with SAR650984 (anti-CD38 antibody) in combination with Rev and Dex in relapse and refractory myeloma has been quite positive with reasonable responses and tolerance. This study is open at Moffitt, UCSF, Wash U, and two additional centers (Ohio and New York). Here is a link to the trial information at clinicaltrials.gov:

http://clinicaltrials.gov/ct2/show/NCT01749969

I would recommend participating in trials with these antibodies or other novel agents as well. Remember clinical trials in myeloma and the wonderful patients and caregivers who participated in these studies are the primary reason for the advances in myeloma to date. Without trials we would not have Revlimid, Velcade, Pomalyst, Kyprolis ...

[Jade]

Re: Experience with daratumumab vs. elotuzumab vs. SAR650984

by Jade on Sun Sep 29, 2013 6:48 pm

Hi, My husband who has been through all the standard therapies is considering a daratumumab or SAR trial . Any updates on your experience would be greatly appreciated. Were you able to qualify for a trial? Thank you.