[debgraff]

Double gammopathy (two m-spikes)

by debgraff on Fri Jan 24, 2014 8:26 pm

I was hoping that someone could shed some light on the recent appearance of two M-spikes on test results.

I have been on myeloma's yellow brick road for five years and have made friends and enemies with Revlimid, Velcade, SCT meds, Pomalyst and radiation. I am currently involved with a Humax-38 [daratumumab] trial and madly in love with this current myeloma friend. I feel great, m-spike has dropped from 1.42 to.60.

However, as I mentioned, another M spike is showing up as well (0.12). I can't seem to find any information on this and would be curious if others have encountered this.

[kjpoppit]

Re: Double gammopathy (two m-spikes)

by kjpoppit on Fri Jan 24, 2014 8:42 pm

My tests have always showed another smaller M-spike. I have never questioned what is about and don't know why there is a second one or what it is about. I just figured it was a normal thing. Anyone?

[dnalex]

Re: Double gammopathy (two m-spikes)

by dnalex on Fri Jan 24, 2014 9:01 pm

I think that it's possibly another clonal population of cells.

At least in the context of transplant, here's a discussion of it
https://myelomabeacon.org/forum/biclonal-myeloma-after-transplant-t1161.html

I don't know what it means in this context, though.