Thanks everyone.
My husband was on RVD for two years and his numbers fluctuated up, then on PVD for almost 3 months and the numbers jumped. Maybe a two-week respite between changing from RVD to PVD. The new specialist we met said that going back on Revlimid is not an option now, whereas his oncologist said he could go back on Revlimid.
We don't know who to listen to, and my husband is too overwhelmed for a third view.
I appreciate hearing from you and everyone else.
Candyce
Forums
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Candyce - Name: Candyce
- Who do you know with myeloma?: Husband
- When were you/they diagnosed?: March 2012
- Age at diagnosis: 69
Re: Does Revlimid become ineffective?
Hi Candyce,
Given when your husband was on the different treatment regimens and his response to them, I can see why your myeloma specialist thinks it would be best not to go back to a treatment regimen that includes Revlimid.
Also, in these sort of cases, I think most of us here would tend to trust the opinion of a myeloma specialist more than a general oncologist (or general hematologist / oncologist).
I will admit that there is some logic in your oncologist's opinion. He / she is probably thinking that the disease started to get really out of control when the Pomalyst was switched in for the Revlimid, so why not go back to a treatment regimen that includes Revlimid and something else -- for example, Kyprolis (carfilzomib), Revlimid, and dexamethasone?
Your myeloma specialist, however, may be thinking about something more intensive, like a regimen involving 4 or 5 drugs. Or he/she may have a clinical trial in mind that would give your husband access to a treatment still being researched.
You can always ask each of the doctors to explain their logic to you and see what makes the most sense. I just think the advice you'll get from the myeloma specialist will be based on more experience with these sorts of situations and a greater awareness of the alternatives that can be pursued (and how they might turn out).
I wish you and your husband the best. Please keep us updated and let us know if you have any additional questions.
Given when your husband was on the different treatment regimens and his response to them, I can see why your myeloma specialist thinks it would be best not to go back to a treatment regimen that includes Revlimid.
Also, in these sort of cases, I think most of us here would tend to trust the opinion of a myeloma specialist more than a general oncologist (or general hematologist / oncologist).
I will admit that there is some logic in your oncologist's opinion. He / she is probably thinking that the disease started to get really out of control when the Pomalyst was switched in for the Revlimid, so why not go back to a treatment regimen that includes Revlimid and something else -- for example, Kyprolis (carfilzomib), Revlimid, and dexamethasone?
Your myeloma specialist, however, may be thinking about something more intensive, like a regimen involving 4 or 5 drugs. Or he/she may have a clinical trial in mind that would give your husband access to a treatment still being researched.
You can always ask each of the doctors to explain their logic to you and see what makes the most sense. I just think the advice you'll get from the myeloma specialist will be based on more experience with these sorts of situations and a greater awareness of the alternatives that can be pursued (and how they might turn out).
I wish you and your husband the best. Please keep us updated and let us know if you have any additional questions.
-
JimNY
Re: Does Revlimid become ineffective?
CoachHoke,
You pose a great question. I've been on maintenance for three years with Revlimid and dex following a SCT -- and I got into and remain in complete remission. I would consider stopping Revlimid and dex if I there was any study that indicated Revlimid and dex will retain their efficacy upon relapse. I'm not sure if that's been studied.
You pose a great question. I've been on maintenance for three years with Revlimid and dex following a SCT -- and I got into and remain in complete remission. I would consider stopping Revlimid and dex if I there was any study that indicated Revlimid and dex will retain their efficacy upon relapse. I'm not sure if that's been studied.
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