Like most, I would like to do all I can to prevent / delay the progression of MGUS. The evidence is there,, in m IMO that obesity and increased animal protein and carbohydrates in the diet have an effect on IGF-1 and adiponectin along with inflammatory cytokines and TNF. These studies are a good place to start.
DH Cohen & D LeRoith, "Obesity, type 2 diabetes, and cancer: the insulin and IGF connection," Endocrine-Related Cancer, Oct 2012 (full text of article)
Abstract:
Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsulinemia, increased levels of IGF, elevated levels of steroid and peptide hormones, and inflammatory markers appear to play a role in the connection between these different diseases. Medications, such as metformin and exogenous insulin, used to treat T2D may affect the risk of cancer and cancer-related mortality. Newer therapies targeting the insulin and IGF1 systems are being developed for use in cancer therapy.
L Fontana et al, "Dietary protein restriction inhibits tumor growth in human xenograft models," Oncotarget, Nov 2013 (full text of article)
Abstract:
Purpose: Data from epidemiological and experimental studies suggest that dietary protein intake may play a role in inhibiting prostate and breast cancer by modulating the IGF/AKT/mTOR pathway. In this study we investigated the effects of diets with different protein content or quality on prostate and breast cancer.
Experimental Design: To test our hypothesis we assessed the inhibitory effect of protein diet restriction on prostate and breast cancer growth, serum PSA and IGF-1 concentrations, mTOR activity and epigenetic markers, by using human xenograft cancer models.
Results: Our results showed a 70% inhibition of tumor growth in the castrate-resistant LuCaP23.1 prostate cancer model and a 56% inhibition in the WHIM16 breast cancer model fed with a 7% protein diet when compared to an isocaloric 21% protein diet. Inhibition of tumor growth correlated, in the LuCaP23.1 model, with decreased serum PSA and IGF-1 levels, down-regulation of mTORC1 activity, decreased cell proliferation as indicated by Ki67 staining, and reduction in epigenetic markers of prostate cancer progression, including the histone methyltransferase EZH2 and the associated histone mark H3K27me3. In addition, we observed that modifications of dietary protein quality, independently of protein quantity, decreased tumor growth. A diet containing 20% plant protein inhibited tumor weight by 37% as compared to a 20% animal dairy protein diet.
Conclusions: Our findings suggest that a reduction in dietary protein intake is highly effective in inhibiting tumor growth in human xenograft prostate and breast cancer models, possibly through the inhibition of the IGF/AKT/mTOR pathway and epigenetic modifications.
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Re: What we eat & how much we weigh to halt progression
Hi Ron!
I have been doing better on restricting protein since you sent that link on the other thread. I also focus on carbs. My average consumptions for Jan, Feb and March were 11 g net carbs per day and 60 g protein per day. I have cut back to about 53 g per day of protein since April. The rest of my calories come from coconut oil, coconut butter, grass fed butter.
Just a quick summary to explain that my multiple myeloma was not a mild case: I was diagnosed May 2012 with kappa free light chains (FLCs) at 1050 mg/L, my kidney function was down to 20%, creatinine 3.1 and beta2 microglobulin was 8.6 after 2 months of Velcade, dex and thalidomide. I was sick.
I had a stem cell transplant November 2012 and my kappa / lambda ratio was up to 2.7 by January just after the transplant. A year after my transplant, my beta2 microglobulin was 6.5. But last spring I asked my oncologist about rumors I had heard about cutting sugar out of diet. He said it is not just sugar, it is keeping blood glucose low and steady by eating a low-carbohydrate diet (and watching protein, as Ron said).
My cancer numbers are better than a year ago, kidney function is up to 45-46%, and creatinine is down to 1.18-1.3 (last 2 months tests). At the same time, I have cut Revlimid from every other day to once a week. I feel so much better - I am about at 3-year anniversary of being diagnosed and diet has been very effective in controlling my myeloma.
I have been doing better on restricting protein since you sent that link on the other thread. I also focus on carbs. My average consumptions for Jan, Feb and March were 11 g net carbs per day and 60 g protein per day. I have cut back to about 53 g per day of protein since April. The rest of my calories come from coconut oil, coconut butter, grass fed butter.
Just a quick summary to explain that my multiple myeloma was not a mild case: I was diagnosed May 2012 with kappa free light chains (FLCs) at 1050 mg/L, my kidney function was down to 20%, creatinine 3.1 and beta2 microglobulin was 8.6 after 2 months of Velcade, dex and thalidomide. I was sick.
I had a stem cell transplant November 2012 and my kappa / lambda ratio was up to 2.7 by January just after the transplant. A year after my transplant, my beta2 microglobulin was 6.5. But last spring I asked my oncologist about rumors I had heard about cutting sugar out of diet. He said it is not just sugar, it is keeping blood glucose low and steady by eating a low-carbohydrate diet (and watching protein, as Ron said).
My cancer numbers are better than a year ago, kidney function is up to 45-46%, and creatinine is down to 1.18-1.3 (last 2 months tests). At the same time, I have cut Revlimid from every other day to once a week. I feel so much better - I am about at 3-year anniversary of being diagnosed and diet has been very effective in controlling my myeloma.
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antelope1225 - Name: Cathy1225
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: May 25 2012
- Age at diagnosis: 55
Re: Re: What we eat & how much we weigh to halt progression
An update is that I have had to be more and more strict with my diet in order to keep my blood sugar down and ketones up. In fact, I started taking berberine, curcumin and resveratrol on March 23rd, and those have helped me get my blood sugar down again.
Not sure if the multiple myeloma cells adapt to my lower blood glucose and somehow get my body to produce more sugar?
Cathy
Not sure if the multiple myeloma cells adapt to my lower blood glucose and somehow get my body to produce more sugar?
Cathy
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antelope1225 - Name: Cathy1225
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: May 25 2012
- Age at diagnosis: 55
Re: What we eat & how much we weigh to halt progression
Hey Ron,
I know that you are maintaining a lower protein and more calorie restricted diet and are having good results. (I am too, though I also restrict carbs) I found another possible explanation for why restricting animal protein is effective: Glutamine is found mostly in meats and animal protein and it, as well as glucose, are the main fuels for cancer cells.
I was just re-reading parts of my book by Thomas Seyfriend "Cancer as a Metabolic Disease" and thought of you and your research on protein and cancer.
Cathy
I know that you are maintaining a lower protein and more calorie restricted diet and are having good results. (I am too, though I also restrict carbs) I found another possible explanation for why restricting animal protein is effective: Glutamine is found mostly in meats and animal protein and it, as well as glucose, are the main fuels for cancer cells.
I was just re-reading parts of my book by Thomas Seyfriend "Cancer as a Metabolic Disease" and thought of you and your research on protein and cancer.
Cathy
-
antelope1225 - Name: Cathy1225
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: May 25 2012
- Age at diagnosis: 55
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