[Zorica]

Diet, dairy, and MGUS: journal article

by Zorica on Mon Feb 27, 2017 9:20 am

The effects of specific and fully appropriate cow’s milk-free diet on disappearance of M-spike (paraprotein) in an MGUS patient:

Juranic, Z., et al, "Could the use of appropriate diet help in the prevention of multiple myeloma?", Journal of B.U.ON. 2009 (abstract at Pubmed

Abstract:

An 83-year-old man with psoriatic arthritis diagnosed in 2000 was tested for serum IgA and IgG immunoreactivity to 3 food constituents and the presence of mono­clonal gammopathy of undetermined significance (MGUS) using enzyme linked immuno­sorbent assay (ELISA), electro­phoresis and immuno­fixation. Cow's milk proteins (CMP), phyto­haemagglutinin P (PHA) and gliadin were used as antigens for ELISA. A greatly enhanced IgA and IgG immuno­reactivity to CMP was observed. Serum analysis by electro­phoresis and immuno­fixation revealed the presence of "M" component (monoclonal IgG (λ) immunoglobulin). A CMP-free diet was started. After 1.5 months, the analysis of serum proteins revealed the disap­pearance of the "M" component. In addition, his serum anti-CMP IgG and IgA both decreased to 0 AU/ml from 892 and 240 AU/ml, respectively. The concentrations of his total serum proteins and IgG were diminished after the CMP-free diet. This case indicates the need for new research aiming at answering whether special food restriction diet for individuals with enhanced immunity to some food constituents would help manage MGUS.

Full text of article (PDF):

Zuranic-Dairy-Free-Diet-MGUS.pdf

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Best regards,
Zorica

[Ruben_1980]

Re: Diet, dairy, and MGUS: journal article

by Ruben_1980 on Thu Jul 13, 2017 5:34 am

Thank you for sharing this Zorica. Very interesting.

I'd like to add another article to this thread, pertaining to a murine study:

Schouten, B, et al, "Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins," The Journal of Allergy and Clinical Immunology, June 2010 (full text of article)

The authors of the study concluded:

"This study indicates that sensitization with cow’s milk proteins can lead to both IgE-dependent and Ig-fLC–dependent allergic hypersensitivity responses. Also, in children affected with CMA [cow's milk allergy] or AD [atopic dermatitis], serum Ig-fLC [immunoglobulin free light chains] concentrations were increased, implying the relevance of Ig-fLC measurements in the diagnoses of human allergic disease."

Accordingly, it may be worthwhile to try a cow's milk free diet.

Best wishes,
Ruben

[Cheryl G]

Re: Diet, dairy, and MGUS: journal article

by Cheryl G on Thu Jul 13, 2017 9:33 am

Hi Ruben,

Welcome to the forum.

I don't think it's surprising that a food allergy would cause a person's light chain levels to increase. Anything that causes an immunoglobulin-related response by the body, whether it's an infection or an allergy, is likely to cause an increase in a person's free light chain levels.

When such an increase is observed, the first question to ask is: Does the increase lead to a kappa-lambda ratio that is out of range? If the ratio is out of range, then this suggests that a clonal process is responsible for the deviation in free light chain levels. Otherwise, the increase is probably polyclonal in nature, as is usually the case with allergies and infections.

Note that, in the paper you cite, not only do the patients with allergies have elevated kappa levels, they also have elevated lambda levels (compared to the control groups). Unfortunately, from what I can tell from my quick read of the paper, the authors did not calculate and report kappa-lambda ratios for the allergy and control patients.

As the authors of one recent paper note, polyclonal increases in free light chain levels "have been described in a variety of inflammatory and autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjögren’s syndrome, atopic dermatitis, asthma, rhinitis, food allergy, idiopathic pulmonary fibrosis, hypersensitivity pneumonitis, chronic obstructive pulmonary disease (COPD), inflammatory bowel disease [23] and multiple sclerosis."

Source:

Polyclonal free light chains: a biomarker of inflammatory disease or treatment target?
https://f1000.com/prime/reports/m/5/4/

[Ruben_1980]

Re: Diet, dairy, and MGUS: journal article

by Ruben_1980 on Thu Jul 13, 2017 1:42 pm

Thank you, Cheryl, for putting the paper in the right perspective.

Best,
Ruben

[Helen L]

Re: Diet, dairy, and MGUS: journal article

by Helen L on Tue Oct 03, 2017 6:10 pm

After reading this article, I decided to eliminate dairy for 3 months, just in case. I figured it was worth trying. Too bad! My M-spike jumped slightly from 8.5 g/L (0.85 g/dL) to 9.7 g/L (0.97 g/dL) . I've bought some yogurt and can't wait to have a bit of cheese again

[FingersCrossed]

Re: Diet, dairy, and MGUS: journal article

by FingersCrossed on Thu Nov 16, 2017 9:17 am

Interesting.

I just did the same experiment: I eliminated all dairy and eggs for the past 3 months. However, I also cut back on my seafood consumption from 5x/week to 2-3x/week. I don't eat any other animal products aside from the occasional serving of organ meat. My comparison labs are from May 2017 and November 2017.

I have IgG Kappa smoldering myeloma so the reason for my experiment was to see if I can do anything to maintain or reverse my smoldering condition. My IgG went from 2,220 mg/dL to 1,986 mg/dL, actually in the normal range for my lab. My M-spike went from 1.7 g/dL to 1.5 g/dL.

That said, these movements could just be normal fluctuation and could have nothing to do with my dairy-free diet. Who knows. All I know is that I'm stable so I'm going to stick with it to see what the next round of labs shows.

[Zorica]

Re: Diet, dairy, and MGUS: journal article

by Zorica on Mon Feb 26, 2018 6:11 pm

Hi to all,

Before the dairy free diet, or gluten free diet, it is necessary to determine is the M paraprotein related to cow's milk proteins, or it is connected with gluten proteins. It is easy to determine this, in the laboratory, by ELISA tests:

1. Analyzing serum for the enhanced: anti-cow's milk IgA, anti- cow's milk IgG, or anti- cow's milk IgM,
2. Analyzing serum for the enhanced: anti-gliadin IgA, anti-gliadin IgG, or anti-gliadin IgM,
3. In the case where specific antibodies are blocked in the form of circulating immune com­plexes, analyze serum proteins by electrophoresis and subsequent immuno­pre­cipita­tion with 0.1% gliadin previously dissolved in 0.1% SDS. (Juranić Z, Radic J, Konic-Ristic A, Jelic S, Besu I, Mihaljevic B. "Antibodies contained in "M" component of some patients with multiple myeloma are directed to food antigens?" Leukemia Research, 2006 Dec;30(12):1585-6 [abstract])

In the case of the enhanced immunoreactivity to some of tested proteins (to cow's milk or to gluten). the effects of this special restrictive diet as the disappearance of M-spike, or of M paraprotein, is to be expected.

(For laboratory staff: it is very difficult to dissolve gliadin. It must be started in 10% SDS, and then gradually, by addition of distilled water make final gliadin solution in of 0.1% gliadin 0.1%SDS).

With regards
Zorica