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Deletion of chromosome 13
Hi, I have a question about deletion of chrom. 13 .I was diagnosed stage 3 w/ spine lesions, IGA Kappa w/ del. chrom 13 and p53. No other abnormalites that I know of. Does this make my multiple myeloma the agressive type? I have responded well to 6 cycles of Velcade, doxil and dex. I have an auto stem cell txp scheduled next month. When I'm reading about overall survival rates ect, I don''t know if I'm considered in the agressivetype. Thanks for any information. Carol Yombik
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cyombik
Re: Deletion of chromosome 13
Was your deletion of chromosome 13 detected by FISH or standard cytogenetics. I was told that if the chromosome 13 deletion was detected only by FISH that it does not necessarily mean that your multiple myeloma is high risk.
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Matt - Name: Matt Linden
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: April 2009
- Age at diagnosis: 44
Re: Deletion of chromosome 13
Put simply, yes you are the aggressive type, but not for the reason that you might think.
See the deletion of the long arm of chromosome 13 (13q), is suspected to be one of the early mutations in myeloma cells. It can be seen in patients with MGUS (monoclonal gammopathy of undetermined significance) and SMM (smoldering myeloma). Seeing chromosome 13 deletion by FISH (fluorescent in-situ hybridization) does NOT mean that you are high risk, but seeing a chromosome 13 deletion on karyotype is high risk. Karyotype is when myeloma cells are allowed to grow in a dish; only approximately 30% of myeloma cells are able to grow in a dish. When they grow in a dish, it's a situation where they are independent of the bone marrow microenvironment and hence a karyotypic deletion of chromosome 13 does signify high risk.
For you, deletion of the p53 gene on the small arm of chromosome 17 (17p) is high risk whether its seen by karyotype or by FISH. As is the translocation between chromosomes 14 and 16, denoted often t(14;16).
All that said, you're probably doing the right thing with Vel/Doxil/Dex followed by autologous transplant and then consideration for 1-2 drug maintenance therapy after transplant.
See the deletion of the long arm of chromosome 13 (13q), is suspected to be one of the early mutations in myeloma cells. It can be seen in patients with MGUS (monoclonal gammopathy of undetermined significance) and SMM (smoldering myeloma). Seeing chromosome 13 deletion by FISH (fluorescent in-situ hybridization) does NOT mean that you are high risk, but seeing a chromosome 13 deletion on karyotype is high risk. Karyotype is when myeloma cells are allowed to grow in a dish; only approximately 30% of myeloma cells are able to grow in a dish. When they grow in a dish, it's a situation where they are independent of the bone marrow microenvironment and hence a karyotypic deletion of chromosome 13 does signify high risk.
For you, deletion of the p53 gene on the small arm of chromosome 17 (17p) is high risk whether its seen by karyotype or by FISH. As is the translocation between chromosomes 14 and 16, denoted often t(14;16).
All that said, you're probably doing the right thing with Vel/Doxil/Dex followed by autologous transplant and then consideration for 1-2 drug maintenance therapy after transplant.
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Dr. Craig Hofmeister - Name: Craig C. Hofmeister, M.D.
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