[yanis]

Deep Vein Thrombosis and RVD

by yanis on Tue Sep 18, 2012 1:01 pm

My Mother is in the second cycle of RVD for first relapse and she was diagnosed with Deep Vein Thrombosis last week
She is actually treated for these illness
My question is wether she will resume on RVD when The DVT will go back

And Does DVT means that she could never take Revlimid or could she be on Revlimid with premedication?


Thanks in advance for your answers and sorry for my english i am in France

[terryl1]

Re: Deep Vein Thrombosis and RVD

by terryl1 on Tue Sep 18, 2012 2:58 pm

Hi, I had a pulmonary embolism in April of this year. In May, I started a clinical trial with carfilzomib, Revlimid and dexamethasone. To prevent a reoccurrence of clots, I take daily shots subcutaneously of Fragmin, an anti-coagulent. Hopefully, your mom is able to do something similar. Good luck.

[Chris M]

Re: Deep Vein Thrombosis and RVD

by Chris M on Fri Sep 21, 2012 8:12 pm

Hi,

My husband experienced a DVT apprx 6months into his Carfilzomib/Revlimid/Dex therapy. He was not happy to be in the ER on Christmas Eve, instead of visiting our kids and grandkids after travelling 4 hours to see them!

When first diagnosed with multiple myeloma, my husband originaly took Lovenox injections 2x/day the first several months to prevent DVTs, then went to just a daily aspirin. That's when he developed his DVT and immediately went back on the daily Lovenox injections.

Despite the DVTs, he didn't miss any of his Carfilzomib/Revlimid/Dex. However, it will probably depend on your mother's health as to what her oncologist recomments. It seems that with multiple myeloma, many patients also have unique health concerns.

Best wishes for you both,
Chris

[terryl1]

Re: Deep Vein Thrombosis and RVD

by terryl1 on Sat Sep 22, 2012 7:23 am

Hi Chris M., It looks like your hushand and I are in the same clinical trial--carfilzomib/Revlimid and dexamethasone. Unfortunately, we also had our bouts with blood clotting issues. I was just curious if he is in the CRD trial at the NIH or Michigan--I think they are the only ones in the US for newly diagnosed? In my case, I had my stem cells collected last week, but do not intend to have a SCT any time soon. With the protocol, one cannot have one anyway till after the trial---2 years. I am currently in VGPR after 4 cycles and pray I get to CR soon. Good luck to you and your husband. Terry L.

[Dr. Adam Cohen]

Re: Deep Vein Thrombosis and RVD

by Dr. Adam Cohen on Tue Sep 25, 2012 1:19 pm

Revlimid can increase the risk of blood clots (deep vein thrombosis and pulmonary embolism), so everyone on this drug should be on some form of preventive medication for clots, unless contraindicated. In the US, aspirin or low doses of an injectable anti-coagulant (such as lovenox or fragmin) are most commonly used. If a DVT or PE develops despite these measures, then the Revlimid is held while the patient starts full dose anti-coagulation (usually with higher doses of the injectable anti-coagulant, or with coumadin). Once the full dose anti-coagulation is at a stable level, the Revlimid generally can be restarted. Hope this helps!