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Re: Darzalex and Kyprolis Treatment
Sounds very manageable from a side-effect perspective Mr. PH! Did your doc give you any idea of how long it would be before you would likely see any improvement in your markers?
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Darzalex and Kyprolis Treatment
Hi Multibilly,
My doc told me that we should see my kappa free light chain level begin to drop during the first eight weeks, if not sooner.
And you are right about side effects. So far they have been minimal.
My doc told me that we should see my kappa free light chain level begin to drop during the first eight weeks, if not sooner.
And you are right about side effects. So far they have been minimal.
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MrPotatohead - Name: MrPotatohead
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: March, 2015
- Age at diagnosis: 65
Re: Darzalex and Kyprolis Treatment
The following are key multiple myeloma blood test results from November 15, 2016, which is just prior to beginning my current Darzalex and Kyprolis treatment.
I will post updates to these results as treatment proceeds.
S Free Lt Chain Nov 15 '16 Ref Range Units
Kappa 11.3 0.33-1.90 mg/dL
Lambda 0.152 0.57-2.60 mg/dL
Kappa/lambda 74.3 0.26-1.60
Cmp Blood Count Nov 15 '16 Ref Range Units
White blood cell 4.2 3.8-10.8 K/uL
Red blood cell 3.3 4.41-6.00 M/uL
Hemoglobin 10.8 14-18 g/dL
Hematocrit 33.1 42-54 %
Platelet count 394 150-450 K/uL
Granulocyte % 40 51-89 %
Lymphocyte % 38.9 10-40 %
Monocyte % 17.5 4-14 %
Metabolic Panel Nov 15 '16 Ref Range Units
Sodium 139 137-147 mmol/L
Potassium 3.5 3.5-5.1 mmol/L
Glucose 146 70-100 mg/dL
BUN 33 5-24 mg/dL
Creatinine 1.6 0.8-1.3 mg/dL
BUN/creatinine 21 7-24
Total protein 7.8 5.3-8.3 g/dL
Albumin 2.8 3.4-5.0 g/dL
Calcium 9.5 8.5-10.4 mg/dL
Bilirubin 0.3 0.1-1.5 mg/dL
LDH 150 87-241 U/L
IgG 1160 1100-1600 mg/dL
IgM 6 40-230 mg/dL
IgA 18 70-400 mg/dL
Beta2-micro. 0.46 0.07-0.18 mg/dL
Alkaline-phos. 54 45-117 U/L
I will post updates to these results as treatment proceeds.
S Free Lt Chain Nov 15 '16 Ref Range Units
Kappa 11.3 0.33-1.90 mg/dL
Lambda 0.152 0.57-2.60 mg/dL
Kappa/lambda 74.3 0.26-1.60
Cmp Blood Count Nov 15 '16 Ref Range Units
White blood cell 4.2 3.8-10.8 K/uL
Red blood cell 3.3 4.41-6.00 M/uL
Hemoglobin 10.8 14-18 g/dL
Hematocrit 33.1 42-54 %
Platelet count 394 150-450 K/uL
Granulocyte % 40 51-89 %
Lymphocyte % 38.9 10-40 %
Monocyte % 17.5 4-14 %
Metabolic Panel Nov 15 '16 Ref Range Units
Sodium 139 137-147 mmol/L
Potassium 3.5 3.5-5.1 mmol/L
Glucose 146 70-100 mg/dL
BUN 33 5-24 mg/dL
Creatinine 1.6 0.8-1.3 mg/dL
BUN/creatinine 21 7-24
Total protein 7.8 5.3-8.3 g/dL
Albumin 2.8 3.4-5.0 g/dL
Calcium 9.5 8.5-10.4 mg/dL
Bilirubin 0.3 0.1-1.5 mg/dL
LDH 150 87-241 U/L
IgG 1160 1100-1600 mg/dL
IgM 6 40-230 mg/dL
IgA 18 70-400 mg/dL
Beta2-micro. 0.46 0.07-0.18 mg/dL
Alkaline-phos. 54 45-117 U/L
Last edited by MrPotatohead on Tue Nov 29, 2016 1:37 am, edited 1 time in total.
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MrPotatohead - Name: MrPotatohead
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: March, 2015
- Age at diagnosis: 65
Re: Darzalex and Kyprolis Treatment
Mr. P.
Thank you for chronicling your experience. I'm hoping that my husband will soon enter a trial with Darzalex, Kyprolis, Revlimid, and dexamethasone, so this is very helpful. I wish you the best of outcomes.
Thank you for chronicling your experience. I'm hoping that my husband will soon enter a trial with Darzalex, Kyprolis, Revlimid, and dexamethasone, so this is very helpful. I wish you the best of outcomes.
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CoachBonnie
Re: Darzalex and Kyprolis Treatment
Thank you, CoachBonnie.
Best of luck to your husband. I hope he achieves a rapid and very long lasting complete response.
Best of luck to your husband. I hope he achieves a rapid and very long lasting complete response.
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MrPotatohead - Name: MrPotatohead
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: March, 2015
- Age at diagnosis: 65
Re: Darzalex and Kyprolis Treatment
Best wishes to you, Mr. PotatoHead! You've got a lot of people rooting for you as you enter your next phase of treatment.
Also, CoachBonnie, best wishes to you and your husband too.
Mike
Also, CoachBonnie, best wishes to you and your husband too.
Mike
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mikeb - Name: mikeb
- Who do you know with myeloma?: self
- When were you/they diagnosed?: 2009 (MGUS at that time)
- Age at diagnosis: 55
Re: Darzalex and Kyprolis Treatment
Many thanks, Mike!
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MrPotatohead - Name: MrPotatohead
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: March, 2015
- Age at diagnosis: 65
Re: Darzalex and Kyprolis Treatment
Best of luck with this treatment regimen, MrP, and thanks for keeping us posted on how it will be going for you. I'm sure I'm not the only one here who hopes this will be a very, very long thread! 
Re: Darzalex and Kyprolis Treatment
TerryH,
Thank you very much for the kind words.
Thank you very much for the kind words.
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MrPotatohead - Name: MrPotatohead
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: March, 2015
- Age at diagnosis: 65
Re: Darzalex and Kyprolis Treatment
Today I received my third Darzalex infusion. My only infusion reaction was a short spike in blood pressure – going from 120/55 to 152/70 for about 20 minutes.
This has also happened during my two previous infusions, but those spikes were a bit higher and lasted longer.
During my first infusion, the infusion was stopped during the blood pressure spike (the nurses take my blood pressure every hour during the infusion), the infusion was stopped for about ten minutes, my blood pressure decreased to within its normal range, and the infusion was restarted.
During my second infusion, the same thing happened and the infusion was again briefly stopped.
During today's infusion, it was not stopped during the spike – blood pressure was just taken more frequently, every half hour. It returned to normal within the first half hour.
Apart from these blood pressure related infusion reactions, and a mild bout of nausea after my first infusion, I have had no other reactions or side effects from Darzalex so far. I am also on Kyprolis, and I have had no side effects from that drug either, apart from some myelosuppression.
My steroid dosage has been changed. Dexamethasone has been discontinued, and the only steroid I will be taking going forward is 125 mg of methylpdrenisolone a day before the Darzalex infusion and 100 mg of methylprednisolone on the day of the Darzalex infusion.
This has also happened during my two previous infusions, but those spikes were a bit higher and lasted longer.
During my first infusion, the infusion was stopped during the blood pressure spike (the nurses take my blood pressure every hour during the infusion), the infusion was stopped for about ten minutes, my blood pressure decreased to within its normal range, and the infusion was restarted.
During my second infusion, the same thing happened and the infusion was again briefly stopped.
During today's infusion, it was not stopped during the spike – blood pressure was just taken more frequently, every half hour. It returned to normal within the first half hour.
Apart from these blood pressure related infusion reactions, and a mild bout of nausea after my first infusion, I have had no other reactions or side effects from Darzalex so far. I am also on Kyprolis, and I have had no side effects from that drug either, apart from some myelosuppression.
My steroid dosage has been changed. Dexamethasone has been discontinued, and the only steroid I will be taking going forward is 125 mg of methylpdrenisolone a day before the Darzalex infusion and 100 mg of methylprednisolone on the day of the Darzalex infusion.
Last edited by MrPotatohead on Thu Dec 01, 2016 11:28 am, edited 4 times in total.
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MrPotatohead - Name: MrPotatohead
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: March, 2015
- Age at diagnosis: 65
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