Hi folks,
From the forum I found out that most of you are being assessed at 100 days post ASCT. Is this 100days after the stem cell infusion, or after hospital discharge? Is this the most common timing?
Since Dad has p53d, the Doctor told him to do a consolidation therapy. Is this also done at 100 days? What if we miss the time frame by 1 month? Is this time frame absolutely critical for the consolidation therapy?
We should not start consolidation therapy during Christmas, should we? It's holiday time!
Forums
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Re: Consolidation therapy timing
100 days from stem cell infusion seems to be the standard for evaluating the response to the transplant procedure. That's usually when consolidation or maintenance therapy is recommended. If you miss it by a month, or decide not to do it, it is no big deal. As with all decisions related to Myeloma treatment, it is your choice as to what you do.
I started Revlimid maintenance at 10 mg at around 100 days, but had a bad reaction to it. At the time I felt that my body just wasn't ready for adding chemicals to it again. My oncologist stopped the Revlimid and told me that when I relapsed that there would be lots of options to try. I didn't achieve CR after transplant for 8 months and then relapsed at about 30 months. I'm now back to taking Rev 15 mg and 20 mg Dex and have responded well again. I was right about my body not being ready for maintenance at 100 days.
Investigate all of the options that are available and then make your decision about what you want to do. But, wait until about the 100 day mark since a lot of recovery takes place during that time period.
Nancy in Phila
I started Revlimid maintenance at 10 mg at around 100 days, but had a bad reaction to it. At the time I felt that my body just wasn't ready for adding chemicals to it again. My oncologist stopped the Revlimid and told me that when I relapsed that there would be lots of options to try. I didn't achieve CR after transplant for 8 months and then relapsed at about 30 months. I'm now back to taking Rev 15 mg and 20 mg Dex and have responded well again. I was right about my body not being ready for maintenance at 100 days.
Investigate all of the options that are available and then make your decision about what you want to do. But, wait until about the 100 day mark since a lot of recovery takes place during that time period.
Nancy in Phila
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NStewart - Name: Nancy Stewart
- Who do you know with myeloma?: self
- When were you/they diagnosed?: 3/08
- Age at diagnosis: 60
Re: Consolidation therapy timing
My husband is also 17p53-
Mayo had him come back 60 days post transplant. If I remember correctly, they did not start him on treatment for about 6 months post transplant.
Mayo had him come back 60 days post transplant. If I remember correctly, they did not start him on treatment for about 6 months post transplant.
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rumnting - Who do you know with myeloma?: husband
- When were you/they diagnosed?: 4/9/11
- Age at diagnosis: 54
Re: Consolidation therapy timing
Dear tpt,
3 months post-transplant is the typical time to consider consolidation and maintenance therapy, as this is how it was done in most studies that have demonstrated an advantage to consolidation and maintenance therapy after transplant. This varies, though, depending on how quickly a patient has recovered from transplant, risk features at initial diagnosis, degree of disease left behind after transplant, and other life circumstances. You should discuss the situation with your oncologist to see how you can navigate around the holidays. However, I would not delay therapy too long in light of the 17p deletion.
Good luck and I hope you enjoy your Christmas!
Pete V.
3 months post-transplant is the typical time to consider consolidation and maintenance therapy, as this is how it was done in most studies that have demonstrated an advantage to consolidation and maintenance therapy after transplant. This varies, though, depending on how quickly a patient has recovered from transplant, risk features at initial diagnosis, degree of disease left behind after transplant, and other life circumstances. You should discuss the situation with your oncologist to see how you can navigate around the holidays. However, I would not delay therapy too long in light of the 17p deletion.
Good luck and I hope you enjoy your Christmas!
Pete V.
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Dr. Peter Voorhees - Name: Peter Voorhees, M.D.
Beacon Medical Advisor
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