[Niki]

Confusing post-transplant immunofixation results

by Niki on Sun Jul 20, 2014 10:36 am

Hello everybody,

When I was diagnosed with myeloma, I had kappa proteinuria and kappa proteinemia according to the initial immunofixation of the urine and serum, which was 2 years ago.

Four months ago, I had a stem cell transplantation because the minimal residual disease was elevated from 0.15% to 0.58% with the 8 color flow cytometry. Prior to the stem cell transplantation the immunofixation was positive for an oligoclonal band IgG kappa and lambda.

One and half months after the transplant, the immunofixation became positive for IgG lambda and now positive for IgG kappa.

Could someone tell me what could that mean? Could that be a sign of relapse?

Initially, when I was diagnosed, my serum kappa free light chain results was 7200 and now it is arround 1.98 (under the normal) with normal range the lambda.

Thank you in advance. Best regards
Niki

[Beacon Staff]

Re: Confusing post-transplant immunofixation results

by Beacon Staff on Tue Sep 16, 2014 12:39 pm

Hi Nikki,

It sounds like you had a very good response to treatment so far. Congratulations.

Please check these two recent forum discussions. They are very detailed, with a lot of useful references, and they appear to answer many of the questions that you have regarding your situation.

"Secondary MGUS pre- and post-transplant?", forum discussion started August 28, 2014

"Impact of different M-spike after transplant on prognosis?", forum discussion started July 25, 2014.

Please let us know what you conclude about your own situation based on those discussions, and whether you have any follow-up questions.