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Can chromosomal abnormalities change over time?

by Lisa Stephenson on Thu Jun 16, 2016 9:34 am

Good morning, friends!

I have a quick questions to put out there to all you multiple myeloma gurus.

Can a patient's chromosome profile change during treatment?

Luckily, I did not have a chromosomal abnormality when I was diagnosed, but I was wondering if that can change from the disease.

Thank you all for your time and wisdom! ;)

Lisa Stephenson
Name: Lisa Stephenson
Who do you know with myeloma?: Me
When were you/they diagnosed?: June 2014
Age at diagnosis: 61
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Re: Can chromosomal abnormalities change over time?

by Multibilly on Thu Jun 16, 2016 9:55 am

Yes. The myeloma clonal cell population can evolve and change and you can develop new chromosomal abnormalities, including when you are undergoing treatment. If the myeloma cell population wasn't prone to evolving, it would be much easier to treat the disease.

Multibilly
Name: Multibilly
Who do you know with myeloma?: Me
When were you/they diagnosed?: Smoldering, Nov, 2012
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Re: Can chromosomal abnormalities change over time?

by Lisa Stephenson on Thu Jun 16, 2016 12:16 pm

Thanks for your quick reply!

Have a great weekend!

Lisa Stephenson
Name: Lisa Stephenson
Who do you know with myeloma?: Me
When were you/they diagnosed?: June 2014
Age at diagnosis: 61
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