I just found out that I have relapsed. I was high risk with PCL and t(14:16).
Will my relapsing cells have the same chromosomal qualities?
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WeatherNurse13 - Name: Gracie
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 10/2012
- Age at diagnosis: 49
Re: Are chromosomal abnormalities the same at relapse?
Hi Gracie,
I'm so sorry to hear about your relapse. I'm trying to recall if you were diagnosed with primary or secondary PCL. I believe you already had an ASCT back in 2/2013, right?
I think that, as you already know, cytogenetic aberrations are pretty common with PCL. I also believe that cytogentic aberrations in PCL can evolve in much the same way that they do with multiple myeloma. That is, new "chromosomal qualities" can develop over time. With PCL, the technical literature also discusses the phenomena of different clonal variations "waxing and waning" over time. So, it could be that a new FISH might reveal something additional or different than your earlier FISH did. I'm not a doc, so please verify all this with your specialist.
Have you already discussed your next steps with your doctor?
Wishing you all the best.
I'm so sorry to hear about your relapse. I'm trying to recall if you were diagnosed with primary or secondary PCL. I believe you already had an ASCT back in 2/2013, right?
I think that, as you already know, cytogenetic aberrations are pretty common with PCL. I also believe that cytogentic aberrations in PCL can evolve in much the same way that they do with multiple myeloma. That is, new "chromosomal qualities" can develop over time. With PCL, the technical literature also discusses the phenomena of different clonal variations "waxing and waning" over time. So, it could be that a new FISH might reveal something additional or different than your earlier FISH did. I'm not a doc, so please verify all this with your specialist.
Have you already discussed your next steps with your doctor?
Wishing you all the best.
Last edited by Multibilly on Wed Jul 30, 2014 8:36 am, edited 1 time in total.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Are chromosomal abnormalities the same at relapse?
Just wanted to say I am so sorry about your relapse.
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Toni - Name: Toni
- Who do you know with myeloma?: self - MGUS
- When were you/they diagnosed?: April 2014
- Age at diagnosis: 51
Re: Are chromosomal abnormalities the same at relapse?
Thanks. I have talked with my doc, but my new biopsy results won't be ready until Friday. He will call me at that time. He is the best!
My remission from primary PCL after ASCT evidently was longer than most. I have learned to be thankful for small things. I am thankful for all of you too. Someone who walks the same path I do.
My remission from primary PCL after ASCT evidently was longer than most. I have learned to be thankful for small things. I am thankful for all of you too. Someone who walks the same path I do.
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WeatherNurse13 - Name: Gracie
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: 10/2012
- Age at diagnosis: 49
Re: Are chromosomal abnormalities the same at relapse?
Gracie,
Like Multibilly, in my readings I have seen it said that chromosomal defects in myeloma cells can change over time, often increasing in type and frequency. Wouldn’t it be nice if the opposite was the case?
So FISH results can change from test to test and changes do not mean they botched the test. Sometimes people make this assumption when they see changes. I would bring up these questions and any questions about your test results with your doctor. He would be able to explain this better. It seems you have one you are really happy with. But I always like to do my research first on the subjects like this so I can have a more informed discussion with my doctors.
Being thankful for the small things is a good mindset for those with myeloma or PCL. I wish you success in getting back into remission and hope someday you can be thankful for big things again too.
Like Multibilly, in my readings I have seen it said that chromosomal defects in myeloma cells can change over time, often increasing in type and frequency. Wouldn’t it be nice if the opposite was the case?
So FISH results can change from test to test and changes do not mean they botched the test. Sometimes people make this assumption when they see changes. I would bring up these questions and any questions about your test results with your doctor. He would be able to explain this better. It seems you have one you are really happy with. But I always like to do my research first on the subjects like this so I can have a more informed discussion with my doctors.
Being thankful for the small things is a good mindset for those with myeloma or PCL. I wish you success in getting back into remission and hope someday you can be thankful for big things again too.
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Eric Hofacket - Name: Eric H
- When were you/they diagnosed?: 01 April 2011
- Age at diagnosis: 44
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