[Priesta]

Can an M-spike resolve itself and not come back?

by Priesta on Sat Dec 13, 2014 12:13 am

Hello,

My M-spike has dropped from 0.9 g/dl to 0.6 g/dl in about 3 months. My lambda light chains went from 228 mg/l down to 181 mg/l. My lambda/kappa ratio is uneven at 0.04.

My question is: Can an M-spike ever just resolve itself and become undectable once you have been diagnosed with it? I have only been tested 2 times so far.

[Multibilly]

Re: Can an M-spike resolve itself and not come back?

by Multibilly on Sat Dec 13, 2014 7:58 am

It's not just going to go away on its own, but you very well may never become symptomatic in your lifetime. Your numbers will vary over time, especially with MGUS and smoldering multiple myeloma.

You might want to consider tracking your involved / uninvolved free light chain ratio (lambda / kappa ratio, in your case), in addition to your lambda value.

You can get an idea of how my numbers as a smoldering patient vary over time at this link:

https://myelomabeacon.org/forum/fenofibrate-tricor-and-multiple-myeloma-t2690-30.html

[Priesta]

Re: Can an M-spike resolve itself and not come back?

by Priesta on Sat Dec 13, 2014 6:57 pm

Ok thank you, Multibilly. I definitely plan on tracking it going forward.

I did start taking curcumin and drinking green tea after my initial diagnosis. I have to wonder if that helped it drop, maybe it was just a coincidence.

[Dr. Prashant Kapoor]

Re: Can an M-spike resolve itself and not come back?

by Dr. Prashant Kapoor on Sun Dec 14, 2014 2:25 am

These are minor fluctuations that can be seen if the same tests are performed on an individual at two different time points. I take solace in the fact that the numbers are not trending in the wrong direction.

All the best.