[Anonymous]

can IgG change?

by Anonymous on Thu Jun 28, 2012 6:50 pm

At diagnosis I was told that I have IgG myeloma. On the written report after the diagnosis it states I have IgA myeloma. Is this most likely a typo or can this diagnosis change?

[Dr. Ken Shain]

Re: can IgG change?

by Dr. Ken Shain on Fri Jun 29, 2012 11:13 am

Most likely a typo.
However, in rare instances myeloma patients can "switch." This typically only happens at relapse and is excedingly rare. Whether it is due to a true change in heavy chain expression or two clones vying for dominance remains a question. Biclonal disease can be seen in ~2% of patients, but usually both clones are quantifiable at the same time.
-Takahashi Blood 1986
-Kyle Mayo Proc 2003

Again, most likely a typo.