I ran across this article on how a person's body mass index (BMI) affects the growth and progression of multiple myeloma. Very interesting.
Excerpt:
"In a new study published in Cancer Letters, American University researchers show how, as body mass index increases, so does the growth and spread of the blood cancer multiple myeloma, which accounts for about 10 percent of all blood cancers in patients.
"Once a person with cancer is out of the normal weight category, their BMI is contributing to multiple myeloma growth and progression," said Katie DeCicco-Skinner, associate professor of biology at American University and lead study author.
DeCicco-Skinner and her colleagues examined the BMI of normal, overweight, obese and morbidly obese patients, and the effects on multiple myeloma."
Related journal article:
Bullwinkle, E.M., et al., "Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling," Cancer Letters, June 15, 2016 (abstract)
Article abstract:
The prevalence of obesity over the last several decades in the United States has tripled among children and doubled among adults. Obesity increases the incidence and progression of multiple myeloma, yet the molecular mechanisms by which adipocytes contribute to cancer development and patient prognosis have yet to be fully elucidated.
Here, we obtained human adipose-derived stem cells (ASCs) from twenty-nine normal (BMI = 20–25 kg/m2), overweight (25–30 kg/m2), obese (30–35 kg/m2), or super obese (35–40 kg/m2) patients undergoing elective liposuction. Upon differentiation, adipocytes were co-cultured with RPMI-8226 and NCI-H929 multiple myeloma cell lines.
Adipocytes from overweight, obese and super obese patients displayed increased PPAR-gamma, cytochrome C, interleukin-6, and leptin protein levels, and decreased fatty acid synthase protein. 8226 multiple myeloma cells proliferated faster and displayed increased pSTAT-3/STAT-3 signaling when cultured in adipocyte conditioned media. Further, adipocyte conditioned media from obese and super obese patients significantly increased multiple myeloma cell adhesion, and conditioned media from overweight, obese and super obese patients enhanced tube formation and expression of matrix metalloproteinase-2.
In summary, our data suggest that adipocytes in the multiple myeloma microenvironment contribute to multiple myelomagrowth and progression and should be further evaluated as a possible therapeutic target.
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DallasGG - Name: Kent
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: 6/20/2013
- Age at diagnosis: 56
Re: Body mass index affects multiple myeloma
This is a very interesting article.
My Dad died at 50 of multiple myeloma, in 1969. He was diagnosed at 47. He was a short, rotund man, about 5'4" - 5'5" (1.65 - 1.68 m). He weighed about 200 pounds (91 kg). My Mom always said she thought his weight was a factor in his disease.
Fast forward to 2014 ... I am diagnosed with multiple myeloma at age 59. At time of diagnosis, not overweight (I had lost some weight from being ill). I was always about 10 - 15 pounds overweight most of my adult life. I think the general consensus about weight is that the more cells you have, the more likely it is that something will go wrong with some of them. At least that was my understanding. Maybe this article sheds more light on the process.
Thanks for the contribution.
My Dad died at 50 of multiple myeloma, in 1969. He was diagnosed at 47. He was a short, rotund man, about 5'4" - 5'5" (1.65 - 1.68 m). He weighed about 200 pounds (91 kg). My Mom always said she thought his weight was a factor in his disease.
Fast forward to 2014 ... I am diagnosed with multiple myeloma at age 59. At time of diagnosis, not overweight (I had lost some weight from being ill). I was always about 10 - 15 pounds overweight most of my adult life. I think the general consensus about weight is that the more cells you have, the more likely it is that something will go wrong with some of them. At least that was my understanding. Maybe this article sheds more light on the process.
Thanks for the contribution.
Re: Body mass index affects multiple myeloma
Oh, swear words.
Do you have ANY idea how frustrating it is to be obese/fat/whatever, go to the doctor, and have everything that could possibly be wrong with you attributed to your weight?
Your thyroid hormones are out of whack? Why, lose some weight, you lazy glutton.
You are depressed? Why of course. YOU ARE TOO FAT.
You are a menopausal woman who is bleeding too much and anemic? Why, just use some self control at the dinner table and this wouldn't have happened to you.
You break your leg? Why, if you didn't weigh so much you would have been able to DODGE that boulder that fell off the mountain. Your fault. Lose weight.
You need cataract surgery? Well, of course. you are too fat. Lose weight.
You have arthritis? Well, get off your lazy butt and LOSE WEIGHT.
SHINGLES? Why, if you weren't so fat the rash wouldn't be covering so much of you. It's your fault. Lose weight.
You have multiple myeloma? Why, it's because you are obese and it's all your fault and if you weren't so fat you wouldn't be as sick.
I'm sorry, but these studies, have they actually done any studies that count, y'know, actual PATIENTS dealing with this issue, instead of fat cells taken from the results of liposuction? (Looking)
Why, no. I don't think they did. But I can hear my doc now the next time I see the man: 'Well, you should have lost weight." Subtext: this is all your fault and now you are just another problem fat person who probably deserves it.'
Lord I'm tired of this sort of thing.
Of course, I also have shingles and am really, really irritable. Sorry about that.
Fat curmudgeons unite!
Do you have ANY idea how frustrating it is to be obese/fat/whatever, go to the doctor, and have everything that could possibly be wrong with you attributed to your weight?
Your thyroid hormones are out of whack? Why, lose some weight, you lazy glutton.
You are depressed? Why of course. YOU ARE TOO FAT.
You are a menopausal woman who is bleeding too much and anemic? Why, just use some self control at the dinner table and this wouldn't have happened to you.
You break your leg? Why, if you didn't weigh so much you would have been able to DODGE that boulder that fell off the mountain. Your fault. Lose weight.
You need cataract surgery? Well, of course. you are too fat. Lose weight.
You have arthritis? Well, get off your lazy butt and LOSE WEIGHT.
SHINGLES? Why, if you weren't so fat the rash wouldn't be covering so much of you. It's your fault. Lose weight.
You have multiple myeloma? Why, it's because you are obese and it's all your fault and if you weren't so fat you wouldn't be as sick.
I'm sorry, but these studies, have they actually done any studies that count, y'know, actual PATIENTS dealing with this issue, instead of fat cells taken from the results of liposuction? (Looking)
Why, no. I don't think they did. But I can hear my doc now the next time I see the man: 'Well, you should have lost weight." Subtext: this is all your fault and now you are just another problem fat person who probably deserves it.'
Lord I'm tired of this sort of thing.
Of course, I also have shingles and am really, really irritable. Sorry about that.
Fat curmudgeons unite!
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dianaiad - Who do you know with myeloma?: Me
- When were you/they diagnosed?: Officially...March 2013
- Age at diagnosis: 63
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