I am looking to try to understand my FISH reports. I have abnormal -13 (but normal 13q-), t(11;14), and 14q32(IGH sep). It sounds like in the interpretation the significance is unknown, but I wanted to see if I could get further information. Is -13 deletion 13? Also, what does "This result indicates persistence or relapse of this patient's plasma cell clone." mean? Thank you so much.
-Elizabeth
December 2012:
+11 (CCNA-XTx3) normal
13q- normal
-13 abnormal
17p- normal
-17 normal
t(11;14) abnormal
14q32(IGH sep) abnormal
-14(3'/5'IGHx3: normal
Interpretation:
The result is abnormal and indicates a plasma cell clone with monsomy 13 and CCND1/IGH fusion, t(11;14). Insufficient plasma cells were observed with probes for chromosomes 3, 7, 9, and 15. This result indicates persistence or relapse of this patient's plasma cell clone.
July 2012:
+9 normal
+15 normal
+11 (CCNA-XTx3) normal
13q- normal
-13 abnormal
17p- normal
-17 normal
t(11;14) abnormal
14q32(IGH sep) abnormal
-14(3'/5'IGHx3: normal
Interpretation:
The result is abnormal and indicates plasma cell clone with monosomy 13 and CCND1/IGH fusion, t(11;14). At diagnosis, the combination of -13 and t(11;14) has uncertain prognostic significance in multiple myeloma. The prognostic significance for these abnormalities in MGUS, amyloidosis, or smoldering multiple myeloma is unknown.
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Re: Attempting to understand FISH - please help!
Dear Elizabeth104,
I too would be interested in finding out some information about the results you have posted since I share some of the same results on my recent BMB. Hopefully, someone will be able to help explain this.
Good luck.
I too would be interested in finding out some information about the results you have posted since I share some of the same results on my recent BMB. Hopefully, someone will be able to help explain this.
Good luck.
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DanaH - Who do you know with myeloma?: Myself, SMM as of 1/2012
- When were you/they diagnosed?: 1/2012
- Age at diagnosis: 54
Re: Attempting to understand FISH - please help!
Thank you, Dana! Good luck to you too.
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elizabeth104 - Name: Elizabeth
- When were you/they diagnosed?: 25 MGUS, 28 SMM
Re: Attempting to understand FISH - please help!
I'm going to chain my doc to the table and have him explain mine to me also. I don't care how busy he is! The -13 from what I understand is deletion 13 which I also have and is not good so they tell me. But heck, how do I know since they can't explain this.
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JBarnes - Name: Jerry Barnes
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: Aug 17, 2012
- Age at diagnosis: 54
Re: Attempting to understand FISH - please help!
JBarnes - HAA! 
If you get any information from your doctor please let me know!
If you get any information from your doctor please let me know!
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elizabeth104 - Name: Elizabeth
- When were you/they diagnosed?: 25 MGUS, 28 SMM
Re: Attempting to understand FISH - please help!
Monosomy 13 (loss of 1 of the 2 copies of chromosome 13) in the absence of other high risk markers is not considered high risk in this day and age. It would be considered an intermediate risk factor. It should be noted that 40 - 50% of patients will have a 13q deletion (only a portion of 1 copy of chromosome 13 missing) or monosomy 13 and 40 - 50% of patients do not have high risk disease! You also have chromosomes 11 and 14 fused together. This is also a more common cytogenetic abnormality and is considered a better risk marker.
The statement, "This result indicates persistence or relapse of this patient's plasma cell clone", means that they were able to detect myeloma chromosome abnormalities in both of the bone marrow samples, suggesting that there were still myeloma cells left around in Dec 2012. If there were no myeloma cells left, the chromosome abnormalities would not have been detected. The blood and urine tests and numbers of myeloma cells on the 2 biopsies will give you a better sense of how things have changed in that period of time.
I hope this helps. Take care!
Pete V.
The statement, "This result indicates persistence or relapse of this patient's plasma cell clone", means that they were able to detect myeloma chromosome abnormalities in both of the bone marrow samples, suggesting that there were still myeloma cells left around in Dec 2012. If there were no myeloma cells left, the chromosome abnormalities would not have been detected. The blood and urine tests and numbers of myeloma cells on the 2 biopsies will give you a better sense of how things have changed in that period of time.
I hope this helps. Take care!
Pete V.
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Dr. Peter Voorhees - Name: Peter Voorhees, M.D.
Beacon Medical Advisor
Re: Attempting to understand FISH - please help!
Dear Dr. Voorhees,
Your response definitely does help. Thank you so much!
Take care,
Elizabeth
Your response definitely does help. Thank you so much!
Take care,
Elizabeth
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elizabeth104 - Name: Elizabeth
- When were you/they diagnosed?: 25 MGUS, 28 SMM
Re: Attempting to understand FISH - please help!
Finally chained my doc to the chair with the FISH results. I think I'm more confused now than before I asked him! He told me I had no high risk factors and to stop focusing on the FISH as it is not the total story of what should be done for the treatment. What the heck, I pay the guy $224 for 20 minute visit I guess I should take his word for it.
My 90 day post SCT was last week and my marrow was clean, no sign of myeloma. My blood still shows .4 M-Spik and 21 light chain. Seems odd to me to have good marrow and not so good blood? At any rate, my under paid (according to him) oncologist has me on maintenance Rev and we'll track the blood this Summer and see what happens. Jerry.
My 90 day post SCT was last week and my marrow was clean, no sign of myeloma. My blood still shows .4 M-Spik and 21 light chain. Seems odd to me to have good marrow and not so good blood? At any rate, my under paid (according to him) oncologist has me on maintenance Rev and we'll track the blood this Summer and see what happens. Jerry.
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JBarnes - Name: Jerry Barnes
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: Aug 17, 2012
- Age at diagnosis: 54
Re: Attempting to understand FISH - please help!
Glad you got some answers, Jerry! Good luck with the Rev maintenance, I hope you have a great summer.
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elizabeth104 - Name: Elizabeth
- When were you/they diagnosed?: 25 MGUS, 28 SMM
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