Had someone before the outbreak of the disease contact with the growth factor G-CSF or heard anything? Does anyone know if G-CSF can promote it in a monoclonal gammopathy the outbreak of the disease?
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Re: Associated G-CSF and multiple myeloma
Hi,
Your question is not clear. Please carefully explain in more detail what you are trying to understand and I will try to help.
Thank you !
Your question is not clear. Please carefully explain in more detail what you are trying to understand and I will try to help.
Thank you !
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
Re: Associated G-CSF and multiple myeloma
Hi,
Sorry, my English is not so good.
I want to know whether cases are known where the administration of G-CSF to an outbreak of multiple myeloma. Or is that impossible, though at the time of stimulation is already available monoclonal gammopathy. Here, due to a stimulation of the donor for an allogeneic transplant.
Thank you.
Monika
Sorry, my English is not so good.
I want to know whether cases are known where the administration of G-CSF to an outbreak of multiple myeloma. Or is that impossible, though at the time of stimulation is already available monoclonal gammopathy. Here, due to a stimulation of the donor for an allogeneic transplant.
Thank you.
Monika
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guest
Re: Associated G-CSF and multiple myeloma
I am still uncertain about your question. But I think you are asking if GCSF can make myeloma worse or stimulate a progression to myeloma (in someone with MGUS) in a donor for an allogeneic stem cell transplant.
This has not been reported Monika.
This has not been reported Monika.
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
Re: Associated G-CSF and multiple myeloma
Hi, my husband has donated stem cells with G-CSF. Nine months later he had a first vertebral fracture. Four months later, the diagnosis of multiple myeloma.
Today we know that at the time of stimulation were already signs of a monoclonal gammopathy. Despite this evidence, no further investigations were initiated, released my husband for the donation.
I think there are myeloma cells. The receptor for G-CSF is on stem cells. With the influence of growth factors, the stem cell divides asymmetrically. This creates a granulocyte and a new pluripotent stem cell. From these pluripotent stem cells, in turn, can develop any type of blood cells. In the presence of monoclonal gammopathy, it may happen that a new myeloma stem cell is formed. I suspect that the disease outbreak is accelerated. Can you tell me what is wrong with this theory?
Thank you. Sincerely
Monika
Today we know that at the time of stimulation were already signs of a monoclonal gammopathy. Despite this evidence, no further investigations were initiated, released my husband for the donation.
I think there are myeloma cells. The receptor for G-CSF is on stem cells. With the influence of growth factors, the stem cell divides asymmetrically. This creates a granulocyte and a new pluripotent stem cell. From these pluripotent stem cells, in turn, can develop any type of blood cells. In the presence of monoclonal gammopathy, it may happen that a new myeloma stem cell is formed. I suspect that the disease outbreak is accelerated. Can you tell me what is wrong with this theory?
Thank you. Sincerely
Monika
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guest
Re: Associated G-CSF and multiple myeloma
This is a good question but there is no absolute black and white answer. Thousands of donors have received GCSF without evidence of an acceleration or development of diseases like MGUS, MDS, colon cancer, breast cancer, lung cancer etc. In addition GCSF is routinely given to patients with many different types of cancer and there is no good evidence that it makes the cancer worse. There is some concern about giving GCSF to patients with acute leukemia.
Another possibility is that your husband already had myeloma or smoldering (asymptomatic) myeloma at the time he donated the stem cells but was was not fully evaluated.
A different concern I would have is could the recipient of the donated stem cells develop myeloma?
I wish you and your husband the best of luck in your struggle with this difficult disease.
Another possibility is that your husband already had myeloma or smoldering (asymptomatic) myeloma at the time he donated the stem cells but was was not fully evaluated.
A different concern I would have is could the recipient of the donated stem cells develop myeloma?
I wish you and your husband the best of luck in your struggle with this difficult disease.
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
Re: Associated G-CSF and multiple myeloma
Electrophoresis of the reference samples showed only faint signs of a monoclonal gammopathy.
The receptor for G-CSF is on stem cells. With the influence of G-CSF the stem cell divides asymmetrically. This creates a granulocyte and a new pluripotent stem cell. You think this is right?
You've said it was not reported. I'm not surprised. It should not be - so it is not. The medicine must say that there is no connection. If there is a suspicion that a mistake has happened, it must be concealed, otherwise no one would donate more. Therefore this is never reported.
The recipient of the donated cells died during the period of one year after transplantation.
The ability being ill, because he wanted to help, hurts very much. Three children, home, work, the future is so hopeless.
Thank you for your good wishes.
Monika
The receptor for G-CSF is on stem cells. With the influence of G-CSF the stem cell divides asymmetrically. This creates a granulocyte and a new pluripotent stem cell. You think this is right?
You've said it was not reported. I'm not surprised. It should not be - so it is not. The medicine must say that there is no connection. If there is a suspicion that a mistake has happened, it must be concealed, otherwise no one would donate more. Therefore this is never reported.
The recipient of the donated cells died during the period of one year after transplantation.
The ability being ill, because he wanted to help, hurts very much. Three children, home, work, the future is so hopeless.
Thank you for your good wishes.
Monika
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guest
Re: Associated G-CSF and multiple myeloma
Monika,
Who were your spouses' stem cells donated to?
Who were your spouses' stem cells donated to?
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suzierose - Name: suzierose
- When were you/they diagnosed?: 2 sept 2011
Re: Associated G-CSF and multiple myeloma
Hello Suzierose,
He was an unknown person, mediated via a file. The recipient died in the following months.
We dont know details about him.
Monika
He was an unknown person, mediated via a file. The recipient died in the following months.
We dont know details about him.
Monika
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guest
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