"T Cell Immunotherapy Show Promising Results For Leukemia"
"Almost 90 percent of children and adults with a highly aggressive form of acute lymphoblastic leukemia (ALL) showed no evidence of cancer after receiving a personalized cell therapy that reprograms a patient's immune system.
In pilot studies of bio-engineered T cells that attack leukemia, 24 of 27 patients (89%) experienced complete responses within 28 days after treatment. In all, 27 patients received the treatment - 22 children treated at The Children's Hospital of Philadelphia and five adults treated at the Hospital of the University of Pennsylvania"
Link:
http://www.science20.com/news_articles/t_cell_immunotherapy_show_promising_results_leukemia-125882
I can't find the original article I read, but it said that this treatment was also going to be applied to multiple myeloma.
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Wayne K - Name: Wayne
- Who do you know with myeloma?: Myself, my sister who passed in '95
- When were you/they diagnosed?: 03/09
- Age at diagnosis: 70
Re: Article about T-cell altering.
The way I understand it is this specific leukemia implementation cannot be used for multiple myeloma. But there are indeed some active investigations under way to re-target this technology to a myeloma-specific protein....and then you have to tweak the approach to each individual patient.
Unfortunately, this specific effort is now caught up in a major lawsuit over ownership of the technology. I remember seeing a thread on the Beacon about this lawsuit...not quite sure where the lawsuit currently stands.
Unfortunately, this specific effort is now caught up in a major lawsuit over ownership of the technology. I remember seeing a thread on the Beacon about this lawsuit...not quite sure where the lawsuit currently stands.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Article about T-cell altering
My oncologist has said that they have used the altered T-cell technology on at least 2 Myeloma patients at Penn. When he told me about it he said that they were both doing well. The synopsis of the IMWG conference that was posted in the IMF online newsletter last week has him reporting that two Myeloma patients have died who received this treatment. When he told me about the trial he said that he didn't think that the correct target on the Myeloma cell had being identified yet, but was optimistic that it would be identified and a more successful technique would be developed. He also said that he loved working in an institution that was doing such ground breaking research and that he was part of it.
Slowly new treatment techniques are being developed that may prove to be standard of care in the not too distant future.
Nancy in Phila
Slowly new treatment techniques are being developed that may prove to be standard of care in the not too distant future.
Nancy in Phila
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NStewart - Name: Nancy Stewart
- Who do you know with myeloma?: self
- When were you/they diagnosed?: 3/08
- Age at diagnosis: 60
Re: Article about T-cell altering
Hi Wayne K,
Dr. Ed Stadtmauer from the University of Pennsylvania discussed this recently at a conference in Milan. Here is a synopsis.
"The remainder of the full morning program consisted of presentations on exciting new fields of therapy and genetic risk stratification. Dr. Ed Stadtmauer from the University of Pennsylvania led off with an overview of his pioneering work in the field of immunotherapy with transgenic (“engineered”) T cells and chimeric antigen receptors. He gave an overview of the history of immunotherapy approaches in myeloma, and called autologous transplant a good platform for immunotherapy, although his new approach with genetically altered NYESO T cells has produced responses even without transplant. Twenty-seven clinical trials using chimeric antigen receptor T cells (CART) are now being conducted at 10 centers in the US. Best results thus far have been seen in ALL patients. Adverse events have been hypogammaglobulinemia, tumor lysis syndrome, and cytokine release syndrome. Two myeloma patients died of heart failure in the MAGE A3 trial. No efficacy data other than stable disease has yet been seen in myeloma patients. These are still early days for this developing therapy in myeloma."
http://myeloma.org/ArticlePage.action?tabId=0&menuId=0&articleId=4411&aTab=-1
All reports point to anti CD19 CAR T cells being most effective for Acute lymphoblastic leukemia.
Mark
Dr. Ed Stadtmauer from the University of Pennsylvania discussed this recently at a conference in Milan. Here is a synopsis.
"The remainder of the full morning program consisted of presentations on exciting new fields of therapy and genetic risk stratification. Dr. Ed Stadtmauer from the University of Pennsylvania led off with an overview of his pioneering work in the field of immunotherapy with transgenic (“engineered”) T cells and chimeric antigen receptors. He gave an overview of the history of immunotherapy approaches in myeloma, and called autologous transplant a good platform for immunotherapy, although his new approach with genetically altered NYESO T cells has produced responses even without transplant. Twenty-seven clinical trials using chimeric antigen receptor T cells (CART) are now being conducted at 10 centers in the US. Best results thus far have been seen in ALL patients. Adverse events have been hypogammaglobulinemia, tumor lysis syndrome, and cytokine release syndrome. Two myeloma patients died of heart failure in the MAGE A3 trial. No efficacy data other than stable disease has yet been seen in myeloma patients. These are still early days for this developing therapy in myeloma."
http://myeloma.org/ArticlePage.action?tabId=0&menuId=0&articleId=4411&aTab=-1
All reports point to anti CD19 CAR T cells being most effective for Acute lymphoblastic leukemia.
Mark
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Mark
Re: Article about T-cell altering
Multibilly I lost sight of the first article I read, but it went on to say that it it was also in the preliminary stages of being tried on another leukemia and multiple myeloma.
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Wayne K - Name: Wayne
- Who do you know with myeloma?: Myself, my sister who passed in '95
- When were you/they diagnosed?: 03/09
- Age at diagnosis: 70
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