[Katrin]

Are there any high risk news?

by Katrin on Wed Nov 02, 2011 5:11 am

Hallo!

I´d like to know if there are any news concerning high risk profiles particularly patients with del17p13???

I´ve read the article about thalidomide?
My father reached a VGPR, do we already know if a maintance therapy is obligate?!Revlimid?

greetings from AUSTRIA;
Katrin

[Dr. Edward Libby]

Re: Are there any high risk news?

by Dr. Edward Libby on Wed Nov 02, 2011 11:40 am

The news for patients with "high risk" myeloma is that myeloma experts are beginning to focus on this subsegment of the disease. New studies will be opening in the near future to learn if we can improve outcome for patients with hypodiploidy, Del17P, t(14;16),t(14;20), t(14;20) and high risk gene expression profilies (GEP) using existing drugs like Revlimid and Velcade. Many experts feel that treatment (induction and maintenance) should be Velcade based as there is eveidnce that bortezomib may help to overcome high risk features of the disease. Keep tuned for now.

[Katrin]

Re: Are there any high risk news?

by Katrin on Tue Nov 08, 2011 1:33 am

Thank you Dr. Libby for answering my questions;

My father got bortezomib [Velcade] induction together wih Caelyx [Doxil -doxorubicin liposomal].
Unfortunately he had neuropathy in his feet.
After ASCT he reached only a VGPR.
During diagnosis he had also a very high calcium level;
I think this is also a hint for a very aggressive disease?!

Now he is in remissions since 6 month......
we hope, time work for us!