[Castaway]

Alpha 1 &2, beta & gamma "detected" in urine - meaning?

by Castaway on Wed Sep 20, 2017 10:02 am

Hello all,

Just arrived at Day + 100 after my autologous stem cell transplant.

I also just received my lab results from the lab website and have a question that I need a little help with. My urine test shows that Alpha 1 & 2, Beta, and Gamma show as detected. The range just says none detected.

Not sure what that means. In my blood tests, these tests have a range, but in the urine test there is not a range. What do these saying "detected" indicate?

Here are some of my interpretations.

Urine,
IFE- negative for monoclonal free light chains

Blood tests,
IFE serum interpretation - no monoclonal protein spike seen
SPEP - No Gamma Globulin Protein spike is seen
Beta and Gamma slightly reduced

[Arizonan]

Re: Alpha 1 &2, beta & gamma "detected" in urine - meaning?

by Arizonan on Thu Sep 21, 2017 11:21 pm

I'm not sure what it means. I've never had that on my results. When you find out, please let us know.

Good luck.

[Ron Harvot]

Re: Alpha 1 &2, beta & gamma "detected" in urine - meaning?

by Ron Harvot on Fri Sep 22, 2017 12:25 pm

The fact that no monoclonal proteins are showing it in your serum free light chain (sFLC), urine free light chain (uFLC) and serum protein electrophoresis (SPEP) is what I saw that is fantastic! That indicates a stringent complete response!. Those are what we all look at for multiple myeloma. The other may be a side effect due to the stem cell transplant. I am not familiar with it either, but it is not something that is focused on as a multiple myeloma marker.

[Castaway]

Re: Alpha 1 &2, beta & gamma "detected" in urine - meaning?

by Castaway on Fri Sep 22, 2017 5:18 pm

Thanks Ron & Arizonan,

I just got back from my transplant doctor who is a 400 mile round trip away. Spent yesterday doing even more labs there than my doctor visit after that. As Ron said, it's most likely from the transplant. He was not concerned with these being detected. He also said that I was clean as far as the myeloma. But again I am reminded that it will come back at some point. So he and the myeloma group will look at my case and decide what I should have as far as any maintenance.

I will also start my immunizations again around December. Not sure what to expect with those. Only issue right now is my IgG is low and if it continues to get any lower I will need an IVIG infusion.

Thank You,
Castaway

[Janet1520]

Re: Alpha 1 &2, beta & gamma "detected" in urine - meaning?

by Janet1520 on Sun Sep 24, 2017 1:01 am

I have have been on treatment 3-1/2 years with Emplitici (elotuzumab) plus Revlimid, Velcade, and dexamethasone (RVD); I have not had a stem cell transplant. My urine tests have shown Alpha 1,2, beta, and gamma detected in urine for 3 years.