[Multibilly]

Actinium-225 to treat multiple myeloma

by Multibilly on Tue May 29, 2018 7:41 pm

I came across this article today in USA Today:

"Cure for some cancers found in a nuclear waste container in Tennessee," USA Today, May 29, 2018 (full text of article)

This is a more clinical account of how the phase 2 myeloid leukemia trial actually went (interesting to see "remission" as an endpoint in a trial; you never see that term used in myeloma trials):

Finn, L.E., et al, "A Phase 2 Study of Actinium-225 (225Ac)-Lintuzumab in Older Patients with Previously Untreated Acute Myeloid Leukemia (AML) Unfit for Intensive Chemotherapy," Blood Blood 2017 130:2638 (ASH 2017 abstract #2638) (full abstract)

And then I found this phase 1 clinical trial that is using Actinium-225 to treat refractory myeloma patients.

"A Phase I Study of Lintuzumab-Ac225 in Patients With Refractory Multiple Myeloma" (information at clinicaltrials.gov)

The monoclonal antibody lintuzumab that they pair the Actinium-225 isotope with targets the CD33 antigen, which shows up on myeloma cells in a fair number of myeloma patients.