[tom123]

30-year-old male - scared about test results

by tom123 on Fri May 15, 2015 10:50 am

Hi,

I am 30 year old male. I recently visited a neurologist because of constant numbness in my left foot. I was also having my hands and feet going numb during sleep, which goes away after I wake up. The results from my blood work requested by the doc are below.

Because of my high globulin levels, doc has forwarded me to an oncologist to further check for amy­loidosis and paraproteinemia. Needless to say, I am scared beyond belief right now. Rest of the test results are in range except for the globulin levels.

It will be of real help if some one can throw some light on it. I have my appointment with the oncologist next week. This wait is making me paranoid. please help.

Protein, Total 8.1 Range 6.1-8.1 G/DL
Albumin % 56.3 Range 52.4-65.3 %
Alpha-1 Globulin % 8.3 Range 2.1-3.7 %
Alpha-2 Globulin % 14.1 Range 6.6-11.4 %
Beta Globulin % 21.3 Range 11.2-15.6 %
Gamma Globulin % 21.3 Range 11.1-20.5 %

Protein, Total 8.1 Range 6.1-8.1 G/DL
Albumin 4.6 Range 3.5-4.7 g/dL
Alpha-1-Globulin 0.7 H Range 0.1-0.3 g/dL
Alpha-2-Globulin 1.1 H Range 0.5-1.0 g/dL
Beta Globulin 1.7 H Range 0.8-1.4 g/dL
Gamma Globulin 1.7 H Range 0.6-1.6 g/dL

Interpretation (Serum)
Abnormal serum protein electrophoresis (note fractionation)
no paraprotein spike seen.

Vitamin 12, Serum 467 200-1100 pg/mL

White Blood Cell Count 4.1 Range 3.8-10.8 Thousand/uL
Red Blood Cell Count 4.84 Range 4.20-5.80 Million/uL
Hemoglobin 14.2 Range 13.2-17.1 g/dL
Hematocrit 41.8 Range 38.5-50.0 %
MCV 86 Range 80-100 fL
MCH 29.3 Range 27-33 pg
MCHC 33.9 Range 32-36 g/dL
Platelet Count 246 Range 140-400 Thousand/uL
RDW 13.8 Range 11.0-15.0 %
MPV 7.7 Range 7.5-11.5 fL
Absolute Neutrophils 2271 Range 1500-7800 cells/uL
Absolute Lymphocytes 1398 Range 850-3900 cells/uL
Absolute Monocytes 312 Range 200-950 cells/uL
Absolute Eosinophils 103 Range 15-500 cells/uL
Absolute Basophils 16 Range 0-200 cells/uL
Neutrophils 55.4 %
Lymphocytes 34.1 %
Reactive Lymphocytes 0.0 %
Monocytes 7.6 %
Eosinophils 2.5 %
Basophils 0.4 %

ESR, Westergren 2 Range 0-15 multiple myeloma/HR

Vitamin D,25-OH,Total,IA 44 Range 30-100 ng/mL

Sodium 140 Range 135-146 mmol/L
Potassium 4.7 Range 3.5-5.3 mmol/L
Chloride 104 Range 98-110 mmol/L
Carbon Dioxide 26 Range 19-30 mmol/L
Glucose 78 Range 65-99 MG/DL
Urea Nitrogen 13 Range 7-25 MG/DL
Creatinine 1.14 Range 0.60-1.35 mg/dL
BUN/Creatinine Ratio N/A Range 6-22

Bun/Creatinine ratio is not reported when the BUN
and creatinine values are within normal limits.

Calcium 10.1 Range 8.6-10.3 MG/DL
Protein, Total 8.1 Range 6.1-8.1 G/DL
Albumin 4.8 Range 3.6-5.1 G/DL
Globulin, Calculated 3.3 Range 1.9-3.7 G/DL
A/G Ratio 1.5 Range 1.0-2.5
Bilirubin, Total 0.7 Range 0.2-1.2 MG/DL
AST 22 Range 10-40 U/L
ALT 20 Range 9-46 U/L
Alkaline Phosphotase 49 Range 40-115 U/L

Thanks

[Multibilly]

Re: 30-year-old male - scared about test results

by Multibilly on Fri May 15, 2015 11:23 am

Tom,

First off, I'm not a doc.

But try not to freak out and take a deep breath. The most important line in these results is:

"Abnormal serum protein electrophoresis (note fractionation) no paraprotein spike seen".

This by itself is a very good sign since the vast majority of folks with multiple myeloma have a measurable serum paraprotein level (M-spike).

Your hemoglobin, calcium, and creatinine levels are also normal, which means your blood tests aren't showing any of the telltale laboratory signs of symptomatic multiple myeloma.

The oncologist will likely also run some tests to look at what are called free light chains, quantitative immunoglobluins, and will test for amyloidosis (which requires a simple biopsy of some tissue).

But nothing so far on these results indicates multiple myeloma, but you need the additional tests with the oncologist to be more certain about what might be going on.

It sounds like you have a very competent doctor to suggest further testing based on elevated globulin levels. But note that other things can cause elevated globulin levels, including in­fec­tion, inflammation, etc. So, try and not jump to any conclusions and worry yourself sick until you get your next round of test results and have had a chance to talk to the oncologist.

Hope this helps.

[tom123]

Re: 30-year-old male - scared about test results

by tom123 on Fri May 15, 2015 12:21 pm

Thanks for the response, Multibilly. That really helps.

I am trying not to freak out, though I cannot help myself but to research on the Internet. Looking at all the possible outcomes is making me feel really sick. Has anyone here reported high globulin levels like mine and not been diagnosed cancerous?

[cdnirene]

Re: 30-year-old male - scared about test results

by cdnirene on Sat May 16, 2015 2:29 am

Tom, almost everyone reading your post has cancer. This is a cancer website. So it is unlikely that anyone would answer yes to your question.

[Dr. Edward Libby]

Re: 30-year-old male - scared about test results

by Dr. Edward Libby on Sat May 16, 2015 1:49 pm

Hello Tom,

I agree with all of the replies here. There is nothing in the test results shown here that suggests to me that you have myeloma or light chain amyloidosis.

Serum free light chain testing and poten­tially a 24-hour urine for Bence Jones proteinuria should be performed to completely rule out myeloma and light chain amyloidosis. If all of these tests are negative, then it is extremely unlikely that you have myeloma or light chain amy­loid­osis.

Is there any family history of amyloidosis or neuropathy?

[tom123]

Re: 30-year-old male - scared about test results

by tom123 on Sun May 17, 2015 1:49 pm

Hello Dr Edward,

Thanks for taking the time to respond. My dad passed away 15 years ago at age 48 because of left ventricular hypertrophy related to a coronary artery disease. (The final cause of death was a related pnuemonia.) He also had some blocked arteries caused by his smoking.

But, doing my research, I read that cardiac amyloidosis can also cause left ventricular hypertrophy. If I remember, he also had some shooting pain in the bottom of his foot. Not tingling or numbness. It is making me worried that he probably had amyloidosis back then and it just went unnoticed or misdiagnosed because of the rareness and lack of knowledge about this disease during that time.

Thanks

[Chillychi]

Re: 30-year-old male - scared about test results

by Chillychi on Mon May 18, 2015 6:55 pm

Hi Tom,

Even though your creatinine level is in the normal range, it is near to upper level. It's trend should be watched I think. Numbness can also be about your kidneys. I am not a doctor, but I have ex­perienced with my mother that the creatinine level may increase in two months from 1.1 to 3!

Before my mother was diagnosed, all creatinine, hgb, calcium, albumin, etc. levels were in the normal range. I don't mean that you have multiple myeloma; probably you don't, because no M-spike, but still you might have a little problem with your kidneys. If there is, and if you can catch it early, you may have a chance to protect them.

In any case, I advise you to increase your vitamin D level. It is good for your kidneys and general health.

Best wishes.

[tom123]

Re: 30-year-old male - scared about test results

by tom123 on Tue May 19, 2015 10:28 am

Thanks for the response. There are so many outcomes from what these results mean. Any other things that I should push my doctor to get me tested? I know early detection is very im­portant in any of these scenarios. So I just want to make myself prepared on what to ask the doctor for.

Thanks