Can anyone explain my results to me? I am confused that the interpretation says "Negative for monoclonal free light chains (Bence Jones Protein) but the lab results say there are free light chains.
(These test results are a follow-up to ones I posted in this discussion thread.)
**I put normal range in parenthesis and my result is after.
Here are the lab results:
Standard Range Your range
Volume, Urine-UPEP24 3000
Time-UPEP24 24
Total Protein-Urine UPEP 24 1.0 (?)
(no established reference range)
Total Protein, Urine Ur/day (10-140 mg) 30mg
(Total Protein is determined by adding the albumin and Kappa/Lambda
light chains. This value may not agree with the total protein as
determined by chemical methods, which characteristically underestimate
urinary light chains)
(I don't understand what this means at all.)
Albumin (Detected) Detected
Alpha 1, Urine (None Detected) None Detected
Alpha 2, Urine (None Detected) None Detected
Beta, Urine (None Detected) None Detected
Gamma Globulin, Ur (None Detected) None Detected
Free Kappa Lt Chain Ur (0.14 -2.42 mg) 0.47
Free Lt Chain Excr rate/day 14.10
Free Lambda Lt Chain, Ur (0.02-0.67 mg) <0.03
Free Lambda Excr rate/day 0.90
Free Kappa/Lambda Ratio (2.04-10.37 ratio) 15.67
Interpretation:
Negative for monoclonal free light chains (Bence Jones Protein)
My SPEP and serum FLC assay were all normal with exception of Alpha 1 globulins, which was 7.2% (normal range was 2.4-4.7%).
I am worried about multiple myeloma, light chain multiple myeloma and amyloidosis.
Can anyone help?
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Re: Understanding follow-up 24-hour urine results
The take away seems to be that your blood work and urine have no evidence of myeloma. What prompted the testing in the first place?
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terryl1 - Name: Terry
- Who do you know with myeloma?: self
- When were you/they diagnosed?: August 10, 2011
- Age at diagnosis: 49
Re: Understanding follow-up 24-hour urine results
My other question is the high kappa / lambda ratio? What does that mean if no Bence proteins present?
Originally sent to hem / onc by primary doctor for a blood calcium level of 10.7.
I am wondering should I see someone that specializes in multiple myeloma or are these results satisfactory in ruling out multiple myeloma, light chain multiple myeloma and/ or amyloidosis?
All responses appreciated.
Originally sent to hem / onc by primary doctor for a blood calcium level of 10.7.
I am wondering should I see someone that specializes in multiple myeloma or are these results satisfactory in ruling out multiple myeloma, light chain multiple myeloma and/ or amyloidosis?
All responses appreciated.
Re: Understanding follow-up 24-hour urine results
I agree about the ratio?? Don't really understand how it can be abnormal when your kappa and lambda chains are normal?
I assume there is a reason they want them closer, but I suppose your doctor will have to explain the reasoning for that.
I assume there is a reason they want them closer, but I suppose your doctor will have to explain the reasoning for that.
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Wayne K - Name: Wayne
- Who do you know with myeloma?: Myself, my sister who passed in '95
- When were you/they diagnosed?: 03/09
- Age at diagnosis: 70
Re: Understanding follow-up 24-hour urine results
Update:
I contacted my doctor and he basically said that the high light chain ratio in the urine didn't mean anything since the light chains were well within the normal range and the sFLC measurements were In the normal range.
The pathologist who did the 24 he urine said that the ratio was very important and was likely an indication of an upward trend of the light chains.
Can anybody give me insight or explanation? Doctor said there is no need to retest and the pathologist said definitely need to retest in 3 months.
I have recently developed microscopic blood in urine and bubbles in my urine to add to the stress.
Any info or advice would be greatly appreciated!
I contacted my doctor and he basically said that the high light chain ratio in the urine didn't mean anything since the light chains were well within the normal range and the sFLC measurements were In the normal range.
The pathologist who did the 24 he urine said that the ratio was very important and was likely an indication of an upward trend of the light chains.
Can anybody give me insight or explanation? Doctor said there is no need to retest and the pathologist said definitely need to retest in 3 months.
I have recently developed microscopic blood in urine and bubbles in my urine to add to the stress.
Any info or advice would be greatly appreciated!
Re: Understanding follow-up 24-hour urine results
I think you can relax a bit. Trust your doctor.
The results you posted are for free light chains in your urine. The kappa/lambda ratio is a bit high (15.67) only because the lambda levels are so very low (<0.03). Remember from fractions: a low denominater means a high ratio.
Your kappa levels are also low, just not as low as your lambda levels.
Also, it is really your free light chains in your serum (blood) that are more important, and you indicated they are normal too.
You may still need to talk to your doctor about reasons for slightly high calcium and blood in urine, but that is likely to be something much much less serious.
The results you posted are for free light chains in your urine. The kappa/lambda ratio is a bit high (15.67) only because the lambda levels are so very low (<0.03). Remember from fractions: a low denominater means a high ratio.
Your kappa levels are also low, just not as low as your lambda levels.
Also, it is really your free light chains in your serum (blood) that are more important, and you indicated they are normal too.
You may still need to talk to your doctor about reasons for slightly high calcium and blood in urine, but that is likely to be something much much less serious.
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Tough Mom - Who do you know with myeloma?: myself
- When were you/they diagnosed?: January 2013
- Age at diagnosis: 45
Re: Understanding follow-up 24-hour urine results
Nephrologist ordered this testing. He said the total protein was high but there is no evidence of multiple myeloma or amyloidosis. There is no indication of Bence Jones proteins, so I assume they were not present.
These tests were done by Labcorp. There is no mention of light chains or heavy chains so does that mean they aren't present? Doesn't IFE identify the presences of heavy and light chain and Bence Jones proteins. Doctor said we would retest in 6 months. Need help with interpretation
Lab Test Results
Pe+Interp(Rfx Ife), 24-Hr Urine test
The urine protein electrophoresis pattern reveals the presence of
M-Spike, % Not Observed Not Observed
Gamma Globulin, U. 29.2 %
Beta Globulin, U 8.9 %
Alpha-2-Globulin, U 11.2 %
Alpha-1-Globulin, U 7.0 %
Albumin, U 43.7 %
Prot,24hr Calculated 214.2 30.0-150.0 mg/24 hr
Protein,Total,Urine 15.3 Not Estab. mg/dL
Immunofixation, Urine
Ife Interpretation:u An apparent normal immunofixation pattern.
These tests were done by Labcorp. There is no mention of light chains or heavy chains so does that mean they aren't present? Doesn't IFE identify the presences of heavy and light chain and Bence Jones proteins. Doctor said we would retest in 6 months. Need help with interpretation
Lab Test Results
Pe+Interp(Rfx Ife), 24-Hr Urine test
The urine protein electrophoresis pattern reveals the presence of
M-Spike, % Not Observed Not Observed
Gamma Globulin, U. 29.2 %
Beta Globulin, U 8.9 %
Alpha-2-Globulin, U 11.2 %
Alpha-1-Globulin, U 7.0 %
Albumin, U 43.7 %
Prot,24hr Calculated 214.2 30.0-150.0 mg/24 hr
Protein,Total,Urine 15.3 Not Estab. mg/dL
Immunofixation, Urine
Ife Interpretation:u An apparent normal immunofixation pattern.
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