Hi,
My husband has been in remission for about 2 years. Diagnosed January 2014, 8 rounds of Revlimid, Velcade, and dexamethasone, maintenance of 10 mg Revlimid. Decided against a stem cell transplant. Very healthy, no problems in remission.
About 4 months ago his M-spike started creeping up slowly. Last month blood work showed 2 M-proteins, 1 measuring 1.0 g/dL (10 g/l). Specialist stopped Revlimid, he will start on 5 mg of Revlimid next week. He may have become sensitized to it. If that doesn't bring down the M-spike, doc will recommend other meds.
In the last month, husband has had hip soreness, knee pain, headaches, fatigue. Orthopedic surgeon x-rayed both hips and knees, found nothing remarkable, gave injection in hip for bursitis. He has had full body x-rays, showing no lesions.
He has relapsed but I am concerned about the hip, knee, fatigue issues.
Anyone have the same dual M-spikes? Same issues at relapse?
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Re: Two M-spikes, joint pain, headaches & fatigue at relapse
You may want to have your husband get a CT scan to check for possible lesions.
I have read about 2 M-spikes before. Is your husband IgA kappa, or what? That may have something to do with it? This Beacon thread talks about that:
"Single M-spike is now two M-spikes - significance?"
I have read about 2 M-spikes before. Is your husband IgA kappa, or what? That may have something to do with it? This Beacon thread talks about that:
"Single M-spike is now two M-spikes - significance?"
Re: Two M-spikes, joint pain, headaches & fatigue at relapse
I have two M-spikes also. It's referred to as biclonal. I have a kappa spike and a lambda spike that together total 0.45 g/dL (4.5 g/L), but has ranged from 1.12 to 0.32 over the past year.
I did the stem cell harvest this past May but am still undecided on the recommended stem cell transplant. When I did the harvest, I was given a high dose Cytoxan treatment that got my M-spike down to 0.32 g/dL, which was disappointing, as I was expecting 0.00.
My maintenance treatment of 15 mg Revlimid 21 days and 20 mg dex once a week has been lowering my M-spike, so I am seeing how long and low I can run with this program.
I did the stem cell harvest this past May but am still undecided on the recommended stem cell transplant. When I did the harvest, I was given a high dose Cytoxan treatment that got my M-spike down to 0.32 g/dL, which was disappointing, as I was expecting 0.00.
My maintenance treatment of 15 mg Revlimid 21 days and 20 mg dex once a week has been lowering my M-spike, so I am seeing how long and low I can run with this program.
Re: Two M-spikes, joint pain, headaches & fatigue at relapse
Thank you, Irankin and f cancer, for responding. He is IgA. And has not had a scan for awhile. If his leg continues to give problems, then I will ask for it. I was not aware that the spikes are added together. While this makes it look worse, the link to the doctor's response is reassuring. Our appointment is next Tuesday, so we will know more then.
Re: Two M-spikes, joint pain, headaches & fatigue at relapse
My cytogenetics report says that I have "two clones with translocation 4; 14 one of which has an additional copy of a derivative chromosome carrying the IGH/FGFR3 gene fusion."
I do not know enough biology to know what this means. Does it mean each clone spews out a different immunoglobulin? Will I have double trouble with my chemo?
Somewhat jokingly, I call one of them my clone of a clone. Like the Star Wars movies, my little clones are the bad guys. I could use a light sabre about now. Zap!
Joe
I do not know enough biology to know what this means. Does it mean each clone spews out a different immunoglobulin? Will I have double trouble with my chemo?
Somewhat jokingly, I call one of them my clone of a clone. Like the Star Wars movies, my little clones are the bad guys. I could use a light sabre about now. Zap!
Joe
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Wobbles - Name: Joe
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: June 2016
- Age at diagnosis: 67
Re: Two M-spikes, joint pain, headaches & fatigue at relapse
Joe,
You can and will develop many different clonal lines over time. And these clonal lines will ebb and flow like the tides as various clonal lines evolve and compete for dominance in controlling your cellular machinery. This is a good article on the subject:
Morgan, G.J., "Evolution, Intra-Clonal Heterogeneity, And Multiple Myeloma," The Myeloma Beacon, Nov 3, 2014
If it weren't for this clonal process that occurs over time, this disease would be far easier to treat.
You can and will develop many different clonal lines over time. And these clonal lines will ebb and flow like the tides as various clonal lines evolve and compete for dominance in controlling your cellular machinery. This is a good article on the subject:
Morgan, G.J., "Evolution, Intra-Clonal Heterogeneity, And Multiple Myeloma," The Myeloma Beacon, Nov 3, 2014
If it weren't for this clonal process that occurs over time, this disease would be far easier to treat.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Two M-spikes, joint pain, headaches & fatigue at relapse
Thanks for that link, Multibilly.
And thanks for all the other posts you've written at this forum. You are a real asset here. I've learned a lot from you already.
Joe
And thanks for all the other posts you've written at this forum. You are a real asset here. I've learned a lot from you already.
Joe
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Wobbles - Name: Joe
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: June 2016
- Age at diagnosis: 67
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