For the 4th month in a row, now 8 months post transplant, my M-spike is holding at 0.1 g/dL (1 g/L).
For context, I was at 0.6 g/dL pre-transplant, 0.3 g/dL 90 days post transplant, 0.2 g/dL 120 days post transplant, and 0.1 g/dL the last 4 months.
I have faith in my doctors saying that stability is great and we don't need to reach zero to be pleased with treatment. That said, I also have read that "complete response" is statistically more indicative of a longer remission, especially for "high risk" patients.
Instead of once again asking my doctors if I should be worried about the lingering M-spike, I've decided to turn to my friends on the Beacon forum to help me understand and work through this. I'm currently receiving maintenance of Kyprolis, Pomalyst, and dex (KPD) (half dose from my initial induction), and the plan is to stay with this as long as three years, assuming no relapse or side-effects.
Should I be concerned? Looking at other treatment? Pressing my doctors more?
Forums
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Mark Pouley - Name: Mark
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: April 2015
- Age at diagnosis: 53
Re: 0.1 g/dL M-spike and holding
Based solely on what happened with me, I'd say that you could just hang in there and see how that number goes. I was still at 0.3 g/dl at 9 months post-transplant. It was over a year before my M-spike dropped to 0 and even longer before I had a negative immunofixation. I've not had a detectible M-spike or positive immunofixation for a couple of years now. (Knock on wood and everything else in the room.)
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Mike F - Name: Mike F
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: May 18, 2012
- Age at diagnosis: 53
Re: 0.1 g/dL M-spike and holding
Sounds like it is slowly going down. Best wishes for it to continue on the down hill slide 
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Dippydoo - Name: DippyDoo
- Who do you know with myeloma?: Myself MGUS
- When were you/they diagnosed?: 2/9/2017
- Age at diagnosis: 49
Re: 0.1 g/dL M-spike and holding
Mike F
What type of treatment regimen are / were you on post transplant?
What type of treatment regimen are / were you on post transplant?
Re: 0.1 g/dL M-spike and holding
Mike F
I'm on a pretty aggressive maintenance of "half dose" Kyprolis, Pomalyst, and dex (KPD). My doctor plans to stick with that for up to three years.
I'm on a pretty aggressive maintenance of "half dose" Kyprolis, Pomalyst, and dex (KPD). My doctor plans to stick with that for up to three years.
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Mark Pouley - Name: Mark
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: April 2015
- Age at diagnosis: 53
Re: 0.1 g/dL M-spike and holding
You're going in the right direction, Mark. Hope it continues to reduce and eventually disappears.
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Colm - Name: Colm
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: smoldering April 2016
- Age at diagnosis: 56
Re: 0.1 g/dL M-spike and holding
Very encouraging news. Hold the line!
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WholeNotherWorld - Who do you know with myeloma?: my husband
- When were you/they diagnosed?: Dec. 2016
- Age at diagnosis: 67
Re: 0.1 g/dL M-spike and holding
Great news Mark!
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PositiveChris - Name: Chris
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: 11/28/2016
- Age at diagnosis: 42
Re: 0.1 g/dL M-spike and holding
Hi Mark,
EJ had an M-spike of 0.1 g/dl (1 g/l) after his stem cell transplant and remained in remission without maintenance for 54 months. The fact that your M-spike continued to go down after the 100 day mark is a good sign.
Lyn
EJ had an M-spike of 0.1 g/dl (1 g/l) after his stem cell transplant and remained in remission without maintenance for 54 months. The fact that your M-spike continued to go down after the 100 day mark is a good sign.
Lyn
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Christa's Mom - Name: Christa's Mom
- Who do you know with myeloma?: Husband
- When were you/they diagnosed?: September, 2010
- Age at diagnosis: 53
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