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Independent, up-to-date news and information for the multiple myeloma community. |
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Carfilzomib continues to show promising results in multiple myeloma according to four studies presented in a poster session yesterday at the 2010 American Society of Hematology annual meeting in Orlando.
Carfilzomib (Kyprolis), developed by Onyx Pharmaceuticals, is a new drug that is currently being investigated as a potential treatment for multiple myeloma. It belongs to the same class of drugs as Velcade (bortezomib). However it works slightly differently by binding to different proteins than Velcade.
Recent research has indicated that …
Long-term follow-up results from a clinical trial show that multiple myeloma patients who underwent two stem cell transplants remained in remission longer and also survived longer than patients who underwent one transplant. These findings are updated results from a previously published study comparing single versus double transplantation.
Multiple myeloma patients are commonly treated with stem cell transplantation. Several studies have shown a survival benefit to having a second transplant a couple of months after the first. However long-term follow-up results …
The International Myeloma Working Group, a group of leading myeloma specialists, recently announced its recommendations for the treatment of multiple myeloma patients with kidney impairment. The group found that novel agents might improve - and possibly reverse - the complications of kidney impairment. In particular, the group recommended that patients with kidney impairment of any severity undergo treatment with Velcade plus dexamethasone, due to its safety and efficacy profile.
Diagnosis Of Kidney Impairment
Kidney impairment affects between 15 and 40 …
The pharmaceutical company Amgen recently announced that its new drug Prolia more effectively prevents bone pain and fractures in patients with advanced bone disease than Zometa. Prolia was noted to have higher efficacy in patients with various types of cancers, including multiple myeloma. The announcement followed the presentation of results from recent Phase 3 trials at the European Society of Medical Oncology Annual Meeting.
Bone disease is frequently associated with multiple myeloma and can cause bone …
The use of single-agent Velcade as maintenance therapy does not significantly improve the response of multiple myeloma patients who fail to achieve a complete response following stem cell transplantation with their own cells, according to a recent study published in the journal Investigational New Drugs.
The researchers recommended that Velcade be used in combination with other myeloma treatments as maintenance therapy. “Velcade is indeed effective in the post-transplant setting, but it must be given as part of a combination therapy …
The International Myeloma Working Group, comprised of many of the world’s top myeloma experts, recently published a report that evaluated the use of key proteins to assess the severity of multiple myeloma-related bone disease. The group determined that some of these proteins are useful in monitoring bone metabolism and skeletal complications during myeloma treatments.
The majority of multiple myeloma patients suffer from bone disease. Approximately 20 percent of patients experience a fracture at the time of their myeloma diagnosis, and …
On Wednesday, the U.S. Food and Drug Administration announced that long-term use of bisphosphonates for osteoporosis places patients at a possible risk for atypical thigh bone fractures. The FDA plans to add this warning to its Medication Guide and to the prescribing information for bisphosphonates approved for the treatment of osteoporosis. The warning will not apply to bisphosphonates typically used in the treatment of multiple myeloma or other cancers.
According to Dr. Craig Hofmeister of the Ohio State University Medical Center, myeloma patients taking …
