According to a recent Greek study, elderly myeloma patients who relapse early after receiving therapy with novel agents have a significantly shorter overall survival time compared to patients who remain in remission longer. In addition, results showed that a poorer quality of response to treatment with novel agents is associated with early relapse in these patients. 

“This study confirms other data that a [better quality of] response argues for a good outcome in patients with myeloma,” said Dr. Edward Libby …

Results of a recent study show that the presence of residual cancer cells and chromosomal abnormalities are strong predictors of early relapse in multiple myeloma patients who achieve a complete response after undergoing stem cell transplantation.

The results were presented last week by Dr. Bruno Paiva, from the Salamanca Hospital Complex in Spain and lead author of the study, at the 16^th Congress of the European Hematology Association (EHA) in London. The authors recommended that myeloma patients with chromosomal abnormalities …

As the myeloma community continues to investigate whether stem cell transplantation or novel agents is the best way to treat newly diagnosed myeloma patients, recent results from a Phase 3 clinical trial indicate that stem cell transplantation may lead to longer disease-free survival.

The results from this study show that more multiple myeloma patients who received a stem cell transplant were alive and disease-free after 24 months compared to patients treated with Revlimid in combination with conventional chemotherapy.

The transplanted …

Results of a Phase 2 clin­i­cal trial show that elotuzumab in com­bi­na­tion with Revlimid and low-dose dexa­meth­a­sone is safe and ef­fec­tive in re­lapsed / refractory mul­ti­ple myeloma patients.

“Elotuzumab in com­bi­na­tion with Revlimid and low-dose dexa­meth­a­sone has a very high re­sponse rate,” said Dr. Philippe Moreau from the Uni­ver­sity Hospital in Nantes, France, when he pre­sented the findings at the 47^th Annual Meeting of the American Society of Clinical Oncology (ASCO) on Sunday.

“[The com­bi­na­tion] seems to be superior to Revlimid …

Results of a Phase 1 clinical trial suggest that the investigational drug LY2127399 in combination with Velcade is safe and effective enough to deserve further study as a potential treatment for multiple myeloma.

“We are very encouraged by these results and would like to move this forward to a randomized trial comparing LY2127399 and Velcade with Velcade alone,” said Dr. Noopur Raje, from Dana-Farber Cancer Institute when she presented these findings at the 47^th Annual Meeting of the American Society …

Results of an ongoing Phase 1 clinical trial indicate that the anti-cancer drug lorvotuzumab mertansine in combination with Revlimid-dexamethasone is active in relapsed/refractory multiple myeloma patients.

“There is encouraging activity observed at all dose levels,” said Dr. Jesus Berdeja from the Sarah Cannon Research Institute in Nashville, Tennessee, who presented these findings at the 47^th Annual Meeting of the American Society of Clinical Oncology (ASCO) on Sunday.

In a summary talk about potential new myeloma treatments, Dr. Nikhil Munshi from …

The International Myeloma Working Group, a group of leading myeloma specialists, recently drafted guidelines for the prevention of blood clots in the veins in multiple myeloma patients. The group recommended the use of heparin or warfarin for patients with a high risk for developing blood clots and aspirin for standard-risk patients.

Dr. Antonio Palumbo of the University of Torino in Italy presented the draft guidelines at the International Myeloma Workshop (IMW) on May 6 in Paris. In email correspondence with …