Articles tagged with: TNB-383B
Press Releases»

Newark, CA (Press Release) – Teneobio, Inc., a clinical-stage biotechnology company developing engineered bispecific antibodies for the treatment of cancer announced today that it has received orphan drug designation by the U.S. Food and Drug Administration (FDA) for the treatment of multiple myeloma.
“New and better treatment options are needed for multiple myeloma. While there are a number of BCMA-targeting agents currently in clinical development, TNB-383B, an anti-BCMAxCD3 currently in Phase I, is a bispecific comprised of a unique T-cell engager designed to maximize the therapeutic window for this class of drugs,” said …
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Derzeit laufen weltweit mehr als 300 klinische Studien, die Behandlungen für das multiple Myelom untersuchen und nach teilnehmenden Patienten suchen. Die meisten dieser Studien erforschen neue Myelomtherapien, die noch nicht für den Einsatz außerhalb klinischer Studien zugelassen sind, und viele dieser sogenannten "investigativen" Therapien haben das Potenzial, extrem effektiv zu sein.
Die Zahl neuer Behandlungen, die für das multiple Myelom entwickelt werden, ist so hoch wie nie zuvor und das weckt große Hoffnung in der Myelom-Gemeinschaft. In nur wenigen Jahren dürften eine Reihe neuer Medikamente für die Behandlung des Myeloms zugelassen werden …
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There currently are more than 300 clinical trials ongoing around the world that are investigating treatments for multiple myeloma and looking for patient participants. Most of these trials are exploring new myeloma therapies that have not yet been approved for use outside of clinical trials, and many of these “investigational” therapies, as they often are called, have the potential to be extremely effective.
The number of new treatments under development for multiple myeloma is greater than it ever has been, and this creates tremendous hope in the myeloma community. In just a …
Press Releases»

Newark, CA (Press Release) – Teneobio, Inc. a clinical-stage biotechnology company developing engineered bispecific antibodies for the treatment of cancer announced today that the first patient has been dosed with TNB-383B in a Phase 1 clinical study to evaluate the safety and tolerability of its differentiated anti-BCMAxCD3, a bispecific antibody that redirects T-cells to kill multiple myeloma cells with minimal cytokine release. Earlier this year, Teneobio’s affiliate TeneoOne, Inc. and AbbVie entered a strategic partnership, giving AbbVie the exclusive right to acquire TeneoOne post-Phase 1 studies and lead the subsequent global development and …
Press Releases»

Newark, CA (Press Release) – Teneobio, Inc. and its affiliate TeneoOne, Inc. announced today that their investigational new drug application (IND) for TNB-383B, a bispecific T-cell engaging antibody for the treatment of multiple myeloma, was cleared for the initiation of Phase I clinical studies by the US Food and Drug Administration (FDA) on April 24th, 2019. The ongoing development of TNB-383B is being pursued in collaboration with AbbVie, Inc.
TNB-383B is a fully human bispecific antibody with two binding moieties for B-Cell Maturation Antigen (BCMA) on one arm and a unique anti-CD3 on …
Press Releases»

North Chicago, IL and Menlo Park, CA (Press Release) – AbbVie (NYSE: ABBV), Teneobio, Inc. and its affiliate TeneoOne, Inc. announced today that they have entered a global strategic transaction to develop and commercialize TNB-383B, a BCMA-targeting immunotherapeutic for the potential treatment of multiple myeloma.
B-cell maturation antigen (BCMA) has emerged as an attractive target for multiple myeloma therapeutics. TNB-383B is a bispecific antibody that simultaneously targets BCMA and CD3, utilizing Teneobio's unique anti-CD3 platform. Through this dual targeting mechanism, TNB-383B is designed to direct the body's own immune system to target and …