Articles tagged with: Tinostamustine
Press Releases»

Stamford, CT (Press Release) – Imbrium Therapeutics L.P., a clinical-stage biopharmaceutical company and operating subsidiary of Purdue Pharma L.P., in conjunction with Mundipharma EDO GmbH, today announced that they have enrolled the first patient in the expansion stage of a Phase 1/2 clinical trial of tinostamustine, an investigational treatment, in patients with relapsed refractory (R/R) hematologic malignancies in the U.S. and Europe.
Following a dose escalation trial to establish tolerability, this expansion phase seeks to investigate the overall response rate, duration of response and safety of five cohorts of patients with R/R cancers, …
Press Releases»
Stamford, CT (Press Release) – Purdue Pharma L.P. today announced successful completion of a first-in-human Phase 1 dose escalation study of tinostamustine in patients with relapsed or refractory hematological malignancies for which there are no available therapies. The study evaluated the safety and pharmacokinetics, and sought to determine the maximum tolerated dose and inform a Phase 2 dose of tinostamustine.1
The multi-acting therapy candidate tinostamustine, previously known as EDO-S101, is a novel and potentially first-in-class alkylating deacetylase inhibitor (AK-DACi) therapy being studied for its potential to improve access to the DNA strands …
Press Releases»
Basel, Switzerland (Press Release) – Mundipharma EDO GmbH (Early Development in Oncology) has announced the initiation of a first-in-human clinical trial of its investigational drug candidate EDO-S101. A first in class, fusion molecule - S101 is currently being developed for the treatment of relapsed-refractory (RR) haematological malignances. This phase 1 study is designed to evaluate the safety and tolerability of ascending doses of EDO-S101 and will be conducted at several sites across the United States and Europe.
EDO-S101 is the first representative of the A-DAC principle, a new approach in chemotherapy that uses …