A recent paper compared the old and new therapies of multiple myeloma in elderly patients. Until 2007, chemotherapy with melphalan and prednisone (MP) was considered the standard treatment. However, new treatments are needed since the median survival rate with the MP regimen is only three years.

One method considered for the elderly is melphalan therapy followed by autologous stem cell transplantation (ASCT). An Italian multiple myeloma study group showed that a 100-milligram dose of melphalan followed by ASCT given twice worked better than MP in terms of response rate, event-free survival, and …

Researchers have achieved major strides in the treatment of multiple myeloma in the last ten years with the use of drugs such as thalidomide (marketed as Thalomid), Revlimid (lenalidomide), and Velcade (bortezomib). In conjunction with high-dose chemotherapy and stem cell transplantation, these various therapeutic options have increased patients’ treatment response and remission rates.

In a recent clinical trial involving Total Treatment 3 (TT3), 80% of patients who received up-front chemotherapy, transplantation, thalidomide, and Velcade achieved nearly complete remission. Of those, 90% have …

Researchers have published new results showing that patients with relapsed or refractory multiple myeloma achieve a better response to treatment with Revlimid (lenalidomide) plus dexamethasone than to dexamethasone alone.  This finding holds for all patients, including those who have previously been treated with thalidomide (marketed as Thalomid).

The new results are based on pooled data from two randomized clinical trials involving more than seven hundred myeloma patients.  The patients had either relapsed multiple myeloma - disease that had initially responded to treatment but had begun to progress again …

Lenalidomide (initially known as CC-5013 and marketed as Revlimid by Celgene) is a derivative of thalidomide introduced in 2004. It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic modality, but has also shown efficacy in the hematological disorders known as the myelodysplastic syndromes. [...]

Thalidomide is a sedative-hypnotic, and multiple myeloma medication. The drug is a potent teratogen in rats, rabbits, and primates including humans: this means that severe birth defects may result if the drug is taken during pregnancy. [...]

Bortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease. [...]