Pamidronic acid (INN) or pamidronate disodium (USAN), pamidronate disodium pentahydrate is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is marketed by Novartis under the brand name Aredia. [...]

Zoledronic acid (INN) or zoledronate (marketed by Novartis under the trade names Zometa, Zomera, Aclasta and Reclast) is a bisphosphonate. Zometa is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. [...]

Samarium-153-ethylene diamine tetramethylene phosphonate, Samarium-153 EDTMP, Quadramet, or simply Samarium-153 is a complex of a radioisotope of the lanthanide element Samarium with carrier EDTMP which is used to treat pain when cancer has spread to the bone. Samarium-153 is injected into a vein and distributes throughout the body. Samarium-153 EDTMP homes in on areas where cancer has invaded the bone. Once there, the radioisotope emits beta particles (electrons) which kill the nearby cancer cells. Pain begins to improve in the first week for most people and the effects can last several months. …