Italian researchers recently found that most myeloma patients are able to collect sufficient stem cells after a short course of induction therapy with Revlimid, allowing them to undergo two consecutive stem cell transplants.

“Revlimid can be used safely before stem cell mobilization, provided that we use only four courses before mobilization and cyclophosphamide is used to mobilize,” said Dr. Antonio Palumbo, lead author of the study and a researcher at the University of Torino in Italy.

The current standard treatment for younger patients with newly diagnosed myeloma includes induction therapy with at …

Results of a recent study show that the presence of residual cancer cells and chromosomal abnormalities are strong predictors of early relapse in multiple myeloma patients who achieve a complete response after undergoing stem cell transplantation.

The results were presented last week by Dr. Bruno Paiva, from the Salamanca Hospital Complex in Spain and lead author of the study, at the 16^th Congress of the European Hematology Association (EHA) in London. The authors recommended that myeloma patients with chromosomal abnormalities and persistent residual disease following transplantation should be considered for additional (consolidation) …

As the myeloma community continues to investigate whether stem cell transplantation or novel agents is the best way to treat newly diagnosed myeloma patients, recent results from a Phase 3 clinical trial indicate that stem cell transplantation may lead to longer disease-free survival.

The results from this study show that more multiple myeloma patients who received a stem cell transplant were alive and disease-free after 24 months compared to patients treated with Revlimid in combination with conventional chemotherapy.

The transplanted patients, however, also experienced more severe side effects compared to non-transplanted patients. …

Spanish researchers recently published long-term follow-up results confirming that a complete response following stem cell transplantation in multiple myeloma patients increases overall and progression-free survival compared to a very good or partial response.

Treatment with high-dose chemotherapy followed by stem cell transplantation is a standard therapeutic approach for younger, newly diagnosed multiple myeloma patients. There has been some debate among researchers, however, as to whether the quality of response following transplantation can predict patient outcome.

In 2000, the same group of researchers published results demonstrating that complete response should be an important …

Yesterday was the second day of the International Myeloma Workshop (IMW) in Paris.  The day was full of presentations from early morning through the evening, and the day concluded with a poster session.

Some of the highlights from Day 2 of the conference are summarized in this article.  For more detailed summaries of the day's sessions, see The Beacon’s extensive Day 2 coverage in the Beacon Forums.

Treating Younger, Newly Diagnosed Myeloma Patients

The first session of the morning was about treating newly diagnosed patients under the age of 65 years.

First, Dr. …

I finished my stem cell transplant in August of 2006.  As I mentioned in my last article, once engrafting of the stem cells takes place, most of the nasty symptoms from the transplant resolve fairly quickly. The lingering symptom was fatigue.

On the bright side, I was home, the worst of the treatment was over, and I was going to make the best of it.

Everyone said, “Don’t fight the fatigue, listen to your body.”  This is true.  If you need to nap, nap. Your body has been through hell and …

High-dose melphalan continues to be the gold standard regimen for multiple myeloma patients prior to autologous stem cell therapy, according to a recent review of research investigating alternative preparative treatments before stem cell transplantation. 

The authors of the review pointed out, however, that current research on variations of this regimen may provide improved transplantation response rates for myeloma patients in the future. 

High-dose chemotherapy prior to stem cell transplantation, often called a preparative or conditioning regimen, is administered with the intention of eliminating cancerous cells from the patient’s bone marrow. High-dose chemotherapy …