Articles tagged with: Response
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Results of a retrospective study conducted at the Mayo Clinic indicate that multiple myeloma patients who respond more gradually to their initial treatment may have better overall survival.
Specifically, the authors of the new study find that newly diagnosed patients who required more than 120 days to achieve their best response to initial treatment had better progression-free and overall survival than patients who achieved their best response in 120 days or less.
The five-year survival rate was 77 percent for patients who achieved their best response to initial treatment in more than …
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Over the last year or two, I have seen an increasing number of patients with multiple myeloma who are deeply worried that they have “failed” treatment because they are not in “complete response” (CR). This phenomenon is gaining further steam with recent interest in “minimal residual disease” (MRD).
In fact, with numerous educational programs, daily emails, and ubiquitous lectures touting a new regimen with even higher complete response rates, I am now almost as worried as them. Of course, the cause of my worry is not that patients have not achieved the …
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Results from a recent clinical study suggest that a new type of response, called an immunophenotypic response, strongly predicts disease progression in elderly multiple myeloma patients. Patients who achieved an immunophenotypic response had superior progression-free survival than patients who achieved a complete response or stringent complete response.
The authors suggested that testing for these three types of responses provides complementary information and that effort should be made to refine response criteria for multiple myeloma.
A number of previous studies have shown that achieving a complete response, which is defined by no detectable …
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Spanish researchers recently published long-term follow-up results confirming that a complete response following stem cell transplantation in multiple myeloma patients increases overall and progression-free survival compared to a very good or partial response.
Treatment with high-dose chemotherapy followed by stem cell transplantation is a standard therapeutic approach for younger, newly diagnosed multiple myeloma patients. There has been some debate among researchers, however, as to whether the quality of response following transplantation can predict patient outcome.
In 2000, the same group of researchers published results demonstrating that complete response should be an important …
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The year 2009 brought a lot of new and exciting advancements in the field of multiple myeloma. Over the course of 2009, The Myeloma Beacon covered more than 100 important myeloma-related studies.
To highlight the most important of these studies, the Myeloma Beacon surveyed leading physicians and researchers in the field. These physicians and researchers were asked to name the three peer reviewed journal articles published in 2009 and the three conference abstracts from 2009 that have the most important findings or implications relating to multiple myeloma.
The top three journal …