Articles tagged with: MRI
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The results of a recent study show that MRI is more accurate than PET-CT for staging newly diagnosed multiple myeloma patients and identifying patients with relapsed disease.
However, the results also show that PET-CT scans are more useful for evaluating a patient’s response to therapy.
The study investigators indicate that their results are similar to those of previous studies that compared MRI and PET-CT for diagnosing patients and evaluating response to therapy. They point out, however, that since their study is the first to compare MRI and PET-CT for identifying relapsed disease, …
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The number of bone lesions detected by whole-body magnetic resonance imaging after stem cell transplantation may predict overall survival of multiple myeloma patients, according to the results of a recent German study.
In particular, patients without bone marrow lesions after stem cell transplantation had significantly better two-year overall survival rates (100 percent) than patients with more than 20 bone marrow lesions (57 percent).
“In our study, we found a negative prognostic effect of residual lesions after therapy,” said Dr. Jens Hillengass from the University of Heidelberg in Germany and lead author of …
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Study Reveals Genetic Differences Between MGUS And Multiple Myeloma – In a recent study, Spanish researchers identified chromosomal abnormalities that were more frequent in patients with active mutiple myeloma than in patients with smoldering myeloma and monoclonal gammopathy of undetermined significance (MGUS), a condition that may later progress to smoldering or active myeloma. The researchers also found that chromosomal abnormalities tend to be more frequent in active myeloma patients than in smoldering myeloma patients, and also more frequent in smoldering myeloma patients than in MGUS patients. For more information, please see the study in Leukemia (abstract).
sCD105 Protein May Be An Indicator For Myeloma Severity – Results of a recent study show that levels of the protein sCD105 circulating in the blood are higher in multiple myeloma patients than in healthy individuals. Higher levels of sCD105 also were associated with more advanced stages of disease. sCD105 is known to play a role in the growth of new blood vessels and may thus contribute to tumor progression in myeloma. Researchers believe these findings warrant further study of sCD105 levels as an indicator for disease activity. For more information, please see the study in the European Journal of Internal Medicine (abstract).
Whole Body MRI Adds Limited Value To Routine Myeloma Remission Testing After Transplantation – A recent study found that the use of whole body magnetic resonance imaging (MRI) to detect persisting or relapsing multiple myeloma post transplant offers little added value compared to current routine laboratory tests. The results of the whole body MRI and routine laboratory tests were in agreement in 79 percent of the patients assessed. For more information, please see the study in European Radiology (abstract).
IMF Myeloma Workshop For Patients And Families – The International Myeloma Foundation (IMF) will be hosting a workshop for multiple myeloma patients and their families on May 19 in Indianapolis, IN. Dr. Rafat Abonour from the Indiana University Bone Marrow and Stem Cell Transplantation Program and nurse Kena Miller from the Roswell Park Cancer Institute in Buffalo, NY, will speak about topics including treatment options, managing side effects, and local clinical trials. For more information or to register, please visit the IMF website.
For a more detailed listing of myeloma-related events, please check the Myeloma Beacon Events Calendar.
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The presence and number of bone marrow lesions detected by whole body magnetic resonance imaging (MRI) can be used to determine the likelihood of progression from smoldering (asymptomatic) multiple myeloma to active (symptomatic) myeloma, according to a study published in the Journal of Clinical Oncology.
Patients with more than one bone marrow lesion progressed sooner than those with one or zero.
Currently, MRI, a technique commonly used to visualize internal structure of the body, is one of the most sensitive techniques for detecting bone marrow lesions and changes in …
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Up to 90 percent of multiple myeloma patients develop bone lesions. Lesions form when cells responsible for bone formation are either suppressed or absent and cells responsible for reabsorbing bone are overactive.
Multiple myeloma patients can experience bone destruction in any type of bone. Almost half of the patients suffer bone lesions in the spine; around one third are affected in the skull, pelvis, and ribs; and under one quarter are affected in the humeri, femora, and mandible.
Bone imaging is an important diagnostic procedure used to monitor bone disease in myeloma …