Articles tagged with: MGUS
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Patients with monoclonal gammopathy of undetermined significance have an increased risk of developing blood clots, according to a recent study published in the European Journal of Haematology. Blood clots were also associated with poor survival in these patients.
“Our findings underline the risk of VTE [blood cots] in the monoclonal gammopathies in general and might in this way serve to increase the awareness of this complication in myeloma patients,” stated Dr. Henrik Gregersen, of the Aalborg Hospital in Denmark and lead author of this study.
While some of the increased risk may …
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The International Myeloma Working Group, a group of top myeloma doctors, recently published a report identifying risk factors for disease progression in patients with the multiple myeloma precursor diseases, monoclonal gammopathy of undetermined significance and smoldering myeloma. In addition, the myeloma experts established guidelines for the monitoring and management of these two conditions. This article, Part 1 in a series, covers the results for monoclonal gammopathy of undetermined significance. Part 2 will cover the results for smoldering myeloma.
The International Myeloma Working Group identified the following risk factors for patients with …
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People with multiple myeloma and its precursor conditions may be at risk for bone fractures and osteoporosis, found a review published in the journal Joint Bone Spine in March.
For those with multiple myeloma, this increased risk of osteoporosis means higher risk of fractures even in places in the bone that do not have cancerous cells. For those with monoclonal gammopathy of undetermined significance (MGUS), a blood disorder characterized by a high level of monoclonal protein, or those with smoldering multiple myeloma, their disease-caused osteoporosis may be an early sign of progression to …
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The year 2009 brought a lot of new and exciting advancements in the field of multiple myeloma. Over the course of 2009, The Myeloma Beacon covered more than 100 important myeloma-related studies.
To highlight the most important of these studies, the Myeloma Beacon surveyed leading physicians and researchers in the field. These physicians and researchers were asked to name the three peer reviewed journal articles published in 2009 and the three conference abstracts from 2009 that have the most important findings or implications relating to multiple myeloma.
The top three journal …
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Dacetuzumab Shows Some Potential For Multiple Myeloma – Results from a Phase 1 clinical trial show that dacetuzumab (SGN-40), an anti-CD40 monoclonal antibody, has some anti-myeloma effects. The best response observed during the trial was stable disease in 20 percent of patients. The study authors found that doses up to 12 mg/kg per week were well tolerated. Most side effects were mild to moderate and included fatigue, headache, nausea, and anemia. The study authors suggest that dacetuzumab may produce better response rates in combination with other myeloma drugs. Two combination trials (one with Revlimid (lenalidomide) and one with Velcade (bortezomib)) are underway. For more information, please see the study in The Haematologica Journal (pdf) and the clinical trial descriptions (dacetuzumab with Revlimid or Velcade) .
Myeloma Awareness Month Teleconference Series – Each Friday during the month of March, the International Myeloma Foundation (IMF) will be hosting a teleconference to raise awareness and provide up-to-date information about multiple myeloma. The teleconferences are scheduled for 7 p.m. EST and will include a 60 minute presentation followed by a 30 minute Q&A. Patients, family members, caregivers, and health care professionals are welcome to join. Please see the IMF Web site for more information.
NCI Designs MGUS/Smoldering Myeloma Study – Researchers from the National Cancer Institute (NCI) are in the process of developing a prospective study with the goal of identifying causes of transformation from monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (both asymptomatic, pre-malignant disorders) to multiple myeloma. The study will enroll 350 patients with MGUS or smoldering myeloma in the United States and follow them for up to five years. For more information, please contact the research nurse for this study, Mary Ann Yancey, at (301) 435-9227 or yanceym@mail.nih.gov.
For a more detailed listing of myeloma related events, please check the Myeloma Beacon Events Calendar.
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Research Confirms MGUS Is Linked To Myeloma, But May Not Be Linked To As Many Diseases As Previously Thought – According to a study published in the August 2009 issue of Mayo Clinic Proceedings, monoclonal gammopathy of undetermined significance (MGUS) may not be linked to as many serious diseases as previously thought. MGUS is a symptomless blood disorder that is a precursor of multiple myeloma. This study confirmed a link between MGUS and 14 diseases. However, before this study, it was also thought to be a precursor for many more diseases. These Mayo Clinic findings may save patients from unnecessary tests and treatment. For more information, please see the Mayo Clinic press release.
Lawsuit Claims Celgene Corporation Misappropriated The Idea Behind Thalidomide – On August 24, Beth R. Jacobson filed a lawsuit against Celgene Corporation claiming “misappropriation of an idea” and “unjust enrichment” concerning the company’s sale of thalidomide (Thalomid) and Revlimid (lenalidomide) for the treatment of myeloma. The suit claims that Jacobson developed the original idea for treating myeloma with thalidomide and is consequently entitled to compensation based on established legal precedent. Jacobson seeks a minimum of $300 million in past damages and 25 percent of the future profits from the sale of Celgene’s thalidomide products. For more information, please see Ms. Jacobson's press release.
Light The Night Walks – On September 11, the Leukemia & Lymphoma Society (LLS) will hold Light the Night Walks in St. Louis and St. Peters, MO. Participants will walk along a two- or three-mile route, carrying a lighted balloon, in support of those touched by blood cancer. For more information, please visit the LLS Web sites for each of the events.
For a more detailed listing of myeloma related events, please check the Myeloma Beacon Events Calendar.
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According to the results of a new study in the journal Annals of Hematology, successfully treating H. pylori, a common bacterial infection, does not lead to monoclonal gammopathy of undetermined significance (MGUS) remission.
These results, also supported by other researchers’ work, refute a previous study that suggested H. pylori eradication could cure approximately 30 percent of MGUS cases.
MGUS is an asymptomatic blood disorder characterized by an abnormally elevated level of monoclonal protein, which is often discovered during testing for other disorders. Monoclonal proteins, or “M-proteins,” are produced by plasma …
