Articles tagged with: Kyphoplasty
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Good morning, myeloma world. Welcome to a new feature here at The Myeloma Beacon: Myeloma Morning.
Starting today, you can come to The Beacon every morning of the week, and a new edition of Myeloma Morning will be waiting for you. Each edition will include summaries of the latest myeloma-related research and myeloma-related news from the business world. We'll also make sure to keep you posted on any interesting conversations going on in the Beacon's myeloma discussion forum.
Our coverage of research developments will focus – as it always …
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The International Myeloma Working Group, a group of leading myeloma specialists, recently published its recommendations for the treatment of bone disease in multiple myeloma patients.
The researchers recommend that all myeloma patients receiving their first anti-myeloma therapy should also receive treatment with bisphosphonates, regardless of whether the patient shows evidence of bone disease on x-rays. They also note that a minimally invasive procedure known as kyphoplasty, as well as low-dose radiation therapy, may be used to reduce severe pain or bone fractures.
In addition, they explain that most bisphosphonates are well tolerated, …
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Opinion: Different Experiences With Myeloma – In the latest article published in the opinion section of The Myeloma Beacon, Vietnam Veteran David Willson, who was diagnosed with multiple myeloma five years ago, writes about how multiple myeloma has affected his life. He feels that his experiences have been very different from those described by most other myeloma patients writing or commenting at The Beacon. He would like to know whether his experiences are an exception, and hear from others who have stories similar to his.
Vertebroplasty And Kyphoplasty May Improve Quality Of Life Of Multiple Myeloma Patients – Results from a recent study indicate that vertebroplasty and kyphoplasty procedures improve quality of life of myeloma patients with spinal fractures. Specifically, the researchers found that both procedures significantly reduced pain and the need for pain killers and improved patients’ physical activity. Both procedures appeared to be equally effective. Vertebroplasty and kyphoplasty are known as vertebral augmentation therapies and have shown in previous studies to decrease pain in myeloma patients. Vertebroplasty involves injecting bone cement directly into the spinal fracture site, which provides pain relief and stabilizes the spine. In kyphoplasty, a balloon is inserted into the fractured bone and inflated to create a void, which is then filled with cement. For more information, please refer to the study in the journal Leukemia (pdf).
Investigational Drug SNX-5422 Shows Some Activity In Multiple Myeloma – Findings from a small Phase 1 trial show that the investigational drug SNX-5422 (PF-04929113), which is being developed by the drug development company Esanex, may be effective in stabilizing refractory or relapsed myeloma. The study included 25 patients with a variety of blood cancers. One patient with myeloma experienced prolonged stabilization of their disease while participating in this study. SNX-5422 belongs to a class of drugs called heat shock protein 90 (Hsp90) inhibitors. Tanespimycin is another Hsp90 inhibitor that was being developed for the treatment of myeloma; however, development of this drug was halted in late-stage clinical trials (see related Beacon news). A Phase 2 study is being planned to test SNX-5422 further in myeloma and lymphoma patients. SNX-5422 is also being investigated for a variety of solid tumors, including breast and lung cancer. For more information, please see the study in the journal Clinical Lymphoma Myeloma and Leukemia (abstract).
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According to a small Italian study, multiple myeloma patients being treated for spinal fractures face a slightly lower risk of cement leakage following kyphoplasty compared to vertebroplasty.
Additionally, the Italian researchers found that several factors, including thicker cement, prior treatment with bone marrow transplantation, and injecting no more than 2 mL of cement regardless of the number of vertebrae being treated, are associated with a lower leakage risk.
Based on these findings, the researchers consider both vertebroplasty and kyphoplasty safe treatment options for myeloma-related spinal lesions. However, they point out that the …
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A group of leading myeloma specialists, known as the International Myeloma Working Group, recently collaborated to develop guidelines for the proper management of bone disease in multiple myeloma. The group recommended that patients with bone disease should be treated with standard dosages of intravenous bisphosphonates. A minimally invasive procedure called kyphoplasty may also be considered to reduce bone pain and improve functional ability.
Dr. David Roodman of the University of Pittsburgh presented these findings at the International Myeloma Workshop (IMW) on May 6 in Paris.
Most multiple myeloma patients develop bone disease, …
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Results of a recent study suggest that balloon kyphoplasty provides better pain relief and more back-specific mobility one month after treatment than non-surgical care in multiple myeloma patients and other cancer patients with spinal fractures.
Based on these findings, the study authors suggested that balloon kyphoplasty be considered as an early treatment option for cancer patients with vertebral compression fractures.
One of the hallmarks of multiple myeloma is bone disease, which is noted by bone pain, bone fractures or lesions, and increased calcium levels. Myeloma bone disease often causes bone loss or …
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ArthroCare Corp. has received clearance from the U.S. Food and Drug Administration to market its Parallax Contour Vertebral Augmentation Device. The Contour device can now be used during minimally invasive surgical procedures to treat spinal fractures caused by multiple myeloma bone lesions.
Weakening of the vertebrae, the bones that make up the spine, can result in vertebral compression fractures. Though the most common cause of vertebral compression fractures is osteoporosis, they may also be caused by multiple myeloma tumors.
Patients with vertebral compression fractures often suffer from debilitating pain and may experience …
