Articles tagged with: Revlimid
News»
Results of a recent Canadian study show that the use of novel agents, particularly Velcade and Revlimid, as salvage therapy after stem cell transplantation improves overall survival and post-relapse survival of multiple myeloma patients, including high-risk patients who relapsed early following transplantation.
Although multiple myeloma remains an incurable disease, the introduction of novel agents, such as thalidomide (Thalomid), Velcade (bortezomib), and Revlimid (lenalidomide) has lead to significant improvements in disease outcomes.
In their analysis, the Canadian researchers sought to determine the effect of these novel agents on the outcomes …
News»
Multiple myeloma patients who continued Revlimid treatment after achieving at least a partial response experienced significantly higher overall survival compared to patients who discontinued treatment, according to a recent study published in the journal Clinical Lymphoma, Myeloma, & Leukemia.
However, the study authors noted that proper management of side effects is necessary for patients to achieve the survival benefit.
Two previous Phase 3 trials showed that Revlimid (lenalidomide) plus dexamethasone (Decadron) improved overall survival more than dexamethasone alone in patients with relapsed or refractory (resistant) myeloma (38.0 months versus …
Turkce»
Geçen ay, uzun süreli Revlimid tedavisi sonrası multipl miyelom hastalarında ikincil kanserlerin ortaya çıkmasıyla ilgili yeni bilgiler yayınlandı.
Bu bilgi, geçen Aralık'taki Amerikan Hematoloji Derneği toplantısında sunulan üç klinik deneyin sonuçlarının analizi sonucu ortaya çıkmıştır. Üç çalışmada da Revlimid idame tedavisi olan multipl miyelom hastalarında, idame tedavisi yapılmayan hastalarla karşılaştırıldığında daha çok ikincil kanserler gözlemlenmiştir.
Revlimid'in (Lenalidomid) üreticisi Celgene perşembe günü yatırımcılar ile olan çeyrek sonu telefon konferansında bu çalışmaların sonuçlarının analizini açıkladı.
Celgene'in CEO'su Robert Hugin ¨Revlimid idame tedavisi olan grupta daha yüksek oranlarda ikincil kanserler gözlemlenmiş olsa da, kontrol grubundaki …
Turkce»
Daha önceden revlimid veya talidomid tedavisi olmuş olan multipl miyelom hastalarında nüks sonrası yapılan revlimid ve pomalidomid tedavisi hastalarda çok iyi yanıt oranlarına ulaşılmasını sağlamıştır. Özellikle, pomalidomid tedavisi ile hastalarda en yüksek yanıt oranlarına ulaşılmıştır.
Rochester, Minnessota'daki Mayo Klinik´den Dr. Sumit Madan, Amerikan Hematoloji Derneği'nin Orlando'daki geçen ayki konferansında bu çalışmanın sonuçlarını sunmuştur.
Daha önce yapılan çalışmalar talidomid (talomid) ve revlimid (lenalidomid) türü imünömodüler ilaçların tanısı yeni konmuş miyelom hastalarında çok etkili tedaviler olduğunu göstermişlerdir. Bu tedaviler çoğunlukla kök hücre tedavisi öncesinde veya kurtarma tedavisi olarak diğer tedavilere yanıt vermeyen hastalarda veya …
News»
Results of a recent study show that multiple myeloma patients who were initially treated with either thalidomide or Revlimid demonstrated strong responses to treatment with Revlimid and pomalidomide following relapse. In particular, researchers observed the highest response rates in patients who received treatment with pomalidomide.
Dr. Sumit Madan of Mayo Clinic in Rochester, Minnesota, presented the study results at the American Society of Hematology annual meeting in Orlando last month.
Research has previously shown that thalidomide (Thalomid) and Revlimid (lenalidomide), which belong to the same class of drugs …
NewsFlash »
Celgene Seeks Expanded Approval For Revlimid In Europe – The pharmaceutical company Celgene announced on Tuesday that it is seeking expanded approval for Revlimid (lenalidomide) as treatment for multiple myeloma in Europe. The European Medicines Agency (EMA) will review approval of Revlimid for maintenance therapy of newly diagnosed myeloma patients who have not progressed after initial therapy with melphalan (Alkeran), prednisone, and Revlimid or after autologous stem cell transplantation. Currently, Revlimid is approved in combination with dexamethasone for the treatment of patients who have received at least one prior therapy. For more information, please see the Celgene press release.
ENMD-2076 Is Safe In Relapsed/Refractory Multiple Myeloma (ASH 2010) – The investigational drug ENMD-2076, which is being developed by the pharmaceutical company EntreMed, is safe in relapsed / refractory multiple myeloma patients, according to the interim Phase 1 trial results presented at the 2010 Meeting of the American Society of Hematology (ASH). Researchers tested four different dose levels (150 mg to 400 mg) in 28-day cycles. They observed progression of disease for all patients receiving the minimum dose of 150 mg. Patients receiving a dose of 300 mg achieved stable disease with reductions in serum M-protein. Researchers did not observe any dose-limiting side effects. Most side effects were mild to moderate and included nausea, diarrhea, and fatigue. The optimal dosage has not yet been determined as the trial is still ongoing. For more information, please see abstract 1957 on the ASH annual meeting website and the clinical trial description.
Daratumumab Emerges As Potential Treatment In CD38-Positive Multiple Myeloma – Preclinical results showed that the experimental drug daratumumab is highly effective at killing cancerous cells that produce the CD38 molecule. The Danish biotechnology company Genmab is currently developing daratumumab for treatment of CD38-positive multiple myeloma tumors. Researchers initially tested a broad array of CD38 antibodies against more than 10 primary tumors from myeloma patients, and daratumumab was found to be the most effective at executing the immune system killing mechanisms. Genmab is currently conducting a Phase 1/2 study to determine the safety and optimal dosage of daratumumab. For more information, please see the study in the Journal of Immunology (abstract) and the clinical trial description.
PBOX-15 Induces Cell Death In Multiple Myeloma Cells – Preclinical results demonstrated that the experimental drug compound PBOX-15 (1,5-benzoxazepine-15), discovered by Irish clinical scientists, is a promising treatment for multiple myeloma. Researchers found that PBOX-15 induced cell death in four different lines of multiple myeloma cells. In two of the cell lines, PBOX-15 increased the number of death receptor genes to stimulate cell death. For more information, please see the study in the British Journal of Cancer (abstract).
News»
Results of a Phase 1 clinical trial suggest that the cancer drug Treanda, in combination with Revlimid and dexamethasone, is highly active and well tolerated in relapsed and refractory multiple myeloma patients.
Dr. Suzanne Lentzsch, of the University of Pittsburgh School of Medicine and Cancer Institute, presented the results of the study at the American Society of Hematology (ASH) 2010 annual meeting in Orlando.
Based on the safety of the Treanda, Revlimid, dexamethasone regimen observed in this study, Dr. Lentzsch believes that this combination may be particularly well suited for older patients …
