Multiple myeloma patients on various thalidomide (Thalomid) combination regimens may develop infections despite preventative drug measures, according to a data analysis performed by Italian researchers. The analysis also identified which factors increase a patient’s likelihood of experiencing severe infection. Researchers presented the results on December 6 at the 51st annual meeting of the American Society of Hematology (ASH) in New Orleans.

In the process of treating multiple myeloma, patients often experience a weakening in their immune system which makes …

At the recent American Society of Hematology (ASH) annual meeting, there were several presentations comparing a drug regimen of Velcade (bortezomib), thalidomide (Thalomid), and dexamethasone (Decadron), abbreviated as VTD, with a drug regimen of thalidomide and dexamethasone, abbreviated as TD, in newly diagnosed multiple myeloma patients.

Update: VTD Versus TD With Double Autologous Stem Cell Transplantation

One of the ASH presentations showed that the addition of Velcade to a thalidomide-dexamethasone regimen and double autologous stem …

Preliminary results from a clinical trial designed to assess the effect of adding thalidomide (Thalomid) to induction therapy prior to autologous stem cell transplantation show that it increases response rates in both young and elderly multiple myeloma patients. These results were presented on December 7^th at the 51^st American Society of Hematology (ASH) meeting.

A total of 1,970 multiple myeloma patients participated in this trial, which split patients up into two separate groups based on age. The younger patients, …

A new study suggests that NPI-0052 (marizomib), a new product being developed by Nereus Pharmaceuticals, Inc., may be more active and less toxic in patients with relapsed or refractory myeloma despite treatment with Velcade (bortezomib) and other drugs. Researchers presented the preliminary results of the Phase 1 trial on December 7 at the 51st annual meeting of the American Society of Hematology (ASH).

Found in marine bacteria, NPI-0052 acts, like Velcade, as a proteasome inhibitor. Both compounds …

The results from a new study indicate that treatment of newly diagnosed multiple myeloma with novel therapeutic agents improves kidney function in most patients, in comparison to treatment with conventional chemotherapy and a high-dose regimen of dexamethasone (Decadron). The authors of the study presented the results of the clinical trial on December 8 at the 51^st American Society of Hematology (ASH) Annual Meeting and Exposition.

Multiple myeloma patients commonly experience complications with kidney function, and kidney impairment is associated …

People with high-risk, smoldering multiple myeloma who are treated with Revlimid (lenalidomide) and dexamethasone (Decadron) take longer to progress to full-blown multiple myeloma than their counterparts, according to interim results of an ongoing Phase 3 study. Researchers presented the findings at the American Society of Hematology’s (ASH) 51st Annual Meeting.

“For the first time, we are seeing a study which is addressing the question of the early treatment of patients with smoldering myeloma,” said Dr. Brian Durie, a …

Preliminary results from a Phase 3 clinical trial show that multiple myeloma patients who received Revlimid (lenalidomide) following a stem cell transplant had a significantly longer period of disease-free survival compared with a placebo group.

The trial (known as CALGB 100104) began with 568 multiple myeloma patients ages 18 to 70 years. No patients had a prior transplant or were treated for myeloma for longer than a year.

All participants received an autologous stem cell transplant, in which their …