Can anyone from from Dana Farber provide an update on the recently completed Phase II
with this new Akt inhibitor?
I think Dr. Paul Richardson was the P.I.
Is he optimistic about the outcome in multiple myeloma patients?
"Alkylphosphocholines are highly active against multiple myeloma (multiple myeloma) cells in vitro and are devoid of myelotoxicity"
Could there actually be a non-myelosuppressive agent on the horizon for multiple myeloma?
"Perifosine induces significant cytotoxicity in both multiple myeloma cell lines and patient multiple myeloma cells resistant to conventional therapeutic agents. Perifosine does not induce cytotoxicity in peripheral blood mononuclear cells. Neither exogenous interleukin-6 (IL-6) nor insulinlike growth factor 1 (IGF-1) overcomes Perifosine-induced cytotoxicity. Importantly, Perifosine induces apoptosis even of multiple myeloma cells adherent to bone marrow stromal cells."
Wow. Just wow. Finally an agent that overrides those pesky stromal-independent MMcells that have been the master of their own fates, promoting disease progress and making themselves resistant to NF-kB so they survive and chew up patients bones... ..despite apoptosis of the other stromal dependent cells...Goody!!!..go get 'em alkylphosphocholines...
and it's oral too!!!!!!!!
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