[bad blood]

From IgG lambda MGUS to IgM lambda MGUS?

by bad blood on Thu Jul 17, 2014 11:02 am

I have to say the CT guided BMB was a breeze. The hospital doc performs it. Lightening fast and no pain but a little pressure.

It was my 3rd BMB since my MGUS diagnosis 8 years ago. I might be jumping the gun. I am a tad alarmed in what I read on my sheet yesterday.

I have always been IgG lambda MGUS. It stated on the sheet for the CT BMB (IgM lambda?) What?

I asked the hospital doc. She said yes! That's correct. The new hemo/onc doc did all my MGUS labs last week. I don't have the results of those or the BMB yet. I know in December I noticed my labs changing. Multiple m-spikes and urine free light chains that where all new.

Anyone have any thoughts on this change in my m-spike?

[jhorner]

Re: From IgG lambda MGUS to IgM lambda MGUS?

by jhorner on Thu Jul 17, 2014 3:56 pm

Hello,

I had IgG kappa MGUS for several years with a trace of lambda (biclonal gammopathy) and then the predominant light chain switched to IgG lambda, with a trace of kappa. However, I believe having two monoclonal proteins of the same antibody is very rare. Bi-clonal gammopathy with two different m-components on two different antibodies, IgG and IgM, which is what you have described, is actually more common and, in fact there was a previous post where it had been determined this is two different disease states, yet does not impact treatment or outcome.

It would be interesting to know if these changes are reflective of disease progression for multiple myeloma or perhaps indicative of another plasma cell dyscrasia.
J

[bad blood]

Re: From IgG lambda MGUS to IgM lambda MGUS?

by bad blood on Fri Jul 18, 2014 10:21 am

Hi jhorner,
Thanks for the reply. I guess I will know more after all the tests come back. Imf myeloma had never heard of mgus switching antibodies...

[Dr. Jatin Shah]

Re: From IgG lambda MGUS to IgM lambda MGUS?

by Dr. Jatin Shah on Fri Jul 18, 2014 7:44 pm

That is unusual for MGUS to transition from IgG to IgM. It will be important to re-evaluate after all the data is available.

[Multibilly]

Re: From IgG lambda MGUS to IgM lambda MGUS?

by Multibilly on Fri Jul 18, 2014 8:45 pm

This sounds like monoclonal banding, which is apparently a good thing when it occurs in a post-transplant situation.

https://myelomabeacon.org/news/2013/01/16/different-m-spike-after-stem-cell-transplantation-linked-to-improved-survival-ash-2012/

[bad blood]

Re: From IgG lambda MGUS to IgM lambda MGUS?

by bad blood on Mon Jul 21, 2014 1:04 pm

Hi MultiBilly,

I am only a MGUSer. Never had any treatments, not even for my osteoporosis!!

When I typed in IgM lambda ... Waldenstrom's macroglobulinaemia. I know there are a bunch more other things it could be as well. I have always had funky blood. I know they are doing some extensive testing on my bone marrow. I will know my results Aug. 6.

Thanks Dr. Jatin Shah,

I will update you when I get all my tests back.

[bad blood]

Re: From IgG lambda MGUS to IgM lambda MGUS?

by bad blood on Tue Jul 22, 2014 8:55 am

My doctor is on vacation and my follow-up appointment is in a couple of weeks. I went online and read my "Flow Cytometry Blood." I guess no need to worry. It said:

Clinical Diagnosis: Lambda monoclonal gammopathy.

I guess I will remain a mystery forever ... at least symptom wise. Thanks for your help. Take care & be well.

[FlightWingsLight]

Re: From IgG lambda MGUS to IgM lambda MGUS?

by FlightWingsLight on Mon May 25, 2015 4:32 pm

I believe it occurs easily for IgM, because of the IgM processing as a first step in creating the IgM identity, further evolving, the clone can then change itself later to another as described in the research. By recoding itself by rearrangement. So if no other Ig identification is evident in the serum but the switch, then maybe the original clone has restructured itself into new cloning IgM. This restructuring capability is indicated in the B cell cancer susceptibility they have for failure to bring about the perfect body immune warrior due to errors in this restructuring process for specific targeting in the immune system response to invasion.

In normal circumstances, a B cell would be perfect before leaving the bone marrow, but when this process fails to create perfection, natural apoptosis would normally occur. Due to this improper restructuring by B cell in cancer, it survives, but restructuring is not limited having many variables. This regulation should occur before B cells leave the bone marrow to circulate. Abhorrent cells escaping this process have lost their ability to die off while in the testing phase, where the regulatory gene has failed to end it's continued replication resulting in cancers.