I know the subject of taking supplements with myeloma drugs comes up a lot so I decided to post this one. Note it is only a one person case study but it may be worth asking your doctor about taking N-acetyl-L-cysteine as a prophylactic to prevent kidney (renal) damage from carfilzomib.
I did not realize that Phase 2 trials were showing 25% of patients treated with carfilzomib had adverse renal effects.
Article: "Carfilzomib-related acute kidney injury may be prevented by N-acetyl-L-cysteine", Journal of Oncology Pharmacy Practice, April 18, 2014
Abstract: Carfilzomib is a second-generation epoxyketone proteasome inhibitor that is approved for treatment of relapsed and refractory multiple myeloma. Phase 2 trials have reported that 25% of treated patients have renal adverse effects. Pre-renal/vasoconstriction-related insult from this chemotherapy agent has been documented. We describe a case of a 78-year-old man with refractory multiple myeloma with acute kidney injury associated with carfilzomib treatment. We show that use of N-acetyl-l-cysteine in our patient partially mitigated the renal injury upon re-challenge. This case report hypothesizes that acute renal injury from carfilzomib is caused by vasoconstriction of the renal vessels, which may be prevented by N-acetyl-l-cysteine."
http://opp.sagepub.com/content/early/2014/04/18/1078155214531804.abstract
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