[Ron Harvot]

Re: Hi everyone - new member with IgG kappa multiple myeloma

by Ron Harvot on Wed Apr 23, 2014 10:10 am

Robin,

Attached is a link to the Wikilite site, which goes into a lot of depth on the FLC assay. Chapter 26 covers, in general, how to interpret the test results. (Very general, so you really need to discuss with your doctor.)

http://www.wikilite.com

Based on what test results you have given, you have had a very good partial response (VGPR). You still have evidence of multiple myeloma (residual disease), and thus you did not have a complete response (CR), at least not yet. Many people live for years with a low M spike on maintenance, but today many doctors would try and drive the multiple myeloma into as low a level as is possible. A deeper response - CR -- is preferable to a VGPR. You may want to read the news section of the Beacon on residual disease:

"Minimal Residual Disease, Deep Sequencing, And Prognosis In Multiple Myeloma"

Ron

[TerryH]

Re: Hi everyone - new member with IgG kappa multiple myeloma

by TerryH on Wed Apr 23, 2014 11:54 am

As usual, Ron has provided a very helpful response. The one thing I would add is this reference to another article here at the Beacon which addresses the issue of exactly how important it is, or is not, to achieve a complete response. The article is written by Dr. Rajkumar, who is a well known myeloma specialist at the Mayo Clinic.

"Should Myeloma Patients Panic If They Do Not Achieve A Complete Response?"

[Robin]

Re: Hi everyone - new member with IgG kappa multiple myeloma

by Robin on Thu Apr 24, 2014 2:19 am

Thanks Ron and Terry. Very helpful.

Any thoughts on my lower than normal Lamda readings?

Thanks again

Robin

[Multibilly]

Re: Hi everyone - new member with IgG kappa multiple myeloma

by Multibilly on Thu Apr 24, 2014 9:07 am

Robin,

Your questions are a bit out of my league. But based on a quick scan of the article below, you "may" find some additional insights on FLCs in this article.

http://www.wardelab.com/16_1.html

I simply googled "suppressed free light chain myeloma" to find this article.

[Robin]

Re: Hi everyone - new member with IgG kappa multiple myeloma

by Robin on Fri Apr 25, 2014 2:35 am

Thanks Multibilly.