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Re: PDAC cytotherapy
H Thomas I
We are not using this type of therapy at RPCI at present. PDAC are Human Placenta-Derived Adherent Cells. This research is being conducted at the Myeloma Institute for Research and Therapy in AK. PDAC appear to be similar if not the same as mesenchymal stem cells (MSCs) which can be derived from a variety of sources including bone marrow. Many investigators are examining the MSCs as they are a potent source of cytokines (cell communication molecules). MSCs are being tested for a variety of indications ranging from repairing heart muscle after a heart attack, modulating the effects of inflammatory bowel disease and GI Graft-versus-Host Disease (GvHD). RPCI participated in studies looking at the effects of MSCs on GvHD. So, Dr. Barlogie's group looked to see if these immature cells could repair bone where there were myeloma lesions in a rat model of multiple myeloma. They found bone re-growth and inhibition of multiple myeloma growth in this rat model of multiple myeloma. So, this may be a very interesting approach to the treatment of multiple myeloma. However, it may be some time before this will be ready to be tested in humans.
We are not using this type of therapy at RPCI at present. PDAC are Human Placenta-Derived Adherent Cells. This research is being conducted at the Myeloma Institute for Research and Therapy in AK. PDAC appear to be similar if not the same as mesenchymal stem cells (MSCs) which can be derived from a variety of sources including bone marrow. Many investigators are examining the MSCs as they are a potent source of cytokines (cell communication molecules). MSCs are being tested for a variety of indications ranging from repairing heart muscle after a heart attack, modulating the effects of inflammatory bowel disease and GI Graft-versus-Host Disease (GvHD). RPCI participated in studies looking at the effects of MSCs on GvHD. So, Dr. Barlogie's group looked to see if these immature cells could repair bone where there were myeloma lesions in a rat model of multiple myeloma. They found bone re-growth and inhibition of multiple myeloma growth in this rat model of multiple myeloma. So, this may be a very interesting approach to the treatment of multiple myeloma. However, it may be some time before this will be ready to be tested in humans.
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Dr. Philip McCarthy - Name: Philip McCarthy Jr., M.D.
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