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Questions and discussion about smoldering myeloma (i.e., diagnosis, risk of progression, potential treatment, etc.)

Urinary infections as sign of myeloma progression?

by Jacqueline on Fri Feb 01, 2019 5:40 pm

Hello,

Is it possible that urinary tract infections (2 cystitis in two month) are signs of myeloma progression?

Cordially,
Jacqueline

Jacqueline
Name: Jacqueline
When were you/they diagnosed?: november 2010
Age at diagnosis: 53

Re: Urinary infections as sign of myeloma progression?

by Nancy Shamanna on Sun Feb 03, 2019 10:24 am

Hello Jacqueline, I think that this depends on where you are as a patient. If you are not on myeloma medications, then infections could mean that your immune system is struggling to fight off infections, be they caused by bacteria (such as UTI's) or viruses. Then this could be a sign that your cancer is increasing.

Or if you are already taking medications, they could be suppressing your immune system too. In that case, the medications could still be effective agains the myeloma. Your doctor might reduce the dosage, or give you a break from chemotherapy in that case.

Either way , you should report it to your doctor. The infections may correlate to your blood tests, as in the white cell blood counts. Hope that helps!

Nancy Shamanna
Name: Nancy Shamanna
Who do you know with myeloma?: Self and others too
When were you/they diagnosed?: July 2009

Re: Urinary infections as sign of myeloma progression?

by Jacqueline on Thu Feb 07, 2019 5:04 am

Thank you Nancy,

I still do not take treatment. But I take dietary supplements.

I see my hematologist next week, I'll talk to him. Thank you again ..

Jacqueline

Jacqueline
Name: Jacqueline
When were you/they diagnosed?: november 2010
Age at diagnosis: 53

Re: Urinary infections as sign of myeloma progression?

by Ruchi on Thu Feb 07, 2019 7:02 am

Hi Jacqueline,

My mother's didease pregressed recently so she was moved from Revlimid, Velcade and dexamethasone regimen to Kyprolis, Revlimid, and dexamethasone. I remember that her urine culture report also showed that she had urine infection. At that time i thought it could be a coincidence, but now it seems it could be due to suppressed immune system as her disease progressed.

Ruchi

Ruchi

Re: Urinary infections as sign of myeloma progression?

by Jacqueline on Sat Feb 16, 2019 10:57 am

I saw my hematologist (a professor) this past Tuesday. For him, urinary tract infections are not related to gammopathy. These are coincidences. And the disease is stable.

It is an anxiety of less!

Thank you for your answers,
Jacqueline

Jacqueline
Name: Jacqueline
When were you/they diagnosed?: november 2010
Age at diagnosis: 53

Re: Urinary infections as sign of myeloma progression?

by jhorner on Sat Feb 16, 2019 12:51 pm

Hello,

My multiple myeloma was diagnosed due to chronic infections, mostly sinus infections and urinary tract infections, but also some serious skin infections. I had hypo­gamma­globulinemia and neutropenia before I even started treatment. I was able to go two years with just IVIG for treatment and I had no infections during that time, but when my disease progressed and I started other treatments, my infections came back. I'm on Darzalex now and it's my understanding that it exacerbates the likeliood of infection. I have been on antibiotics 2x in 3 months for urinary tract infections.

Best,
J

jhorner
Name: Magpie
Who do you know with myeloma?: Myself
When were you/they diagnosed?: 2013
Age at diagnosis: 49


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