[suzierose]

KSP Inhibitors ARRY-520 commentary on multiple myeloma

by suzierose on Thu Dec 13, 2012 9:15 pm

I am posting commentary, just so we know what is on the horizon and why it may be effective in multiple myeloma...this is news we all need to keep in mind, if we should relapse.

I have no opinion as the data is still not conclusive, BUT, these are things we can be aware of if we should relapse or become refractory.

OPTIONS!!! are the name of the game.
Choices are good to have.

"ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and apoptosis in actively dividing tumor cells. Because KSP is not involved in postmitotic processes (ie, neuronal transport), ARRY-520 does not cause the peripheral neuropathy often associated with tubulin-targeting agents......
"ARRY-520 is a first-in class drug in myeloma with a novel mechanism of action that is very well tolerated and importantly shows very encouraging clinical activity in heavily pretreated patients who have limited therapeutic options,” said Dr. Shah."

http://www.cancernetwork.com/conference-reports/ash2012/content/article/10165/2119650

[LibbyC]

Re: KSP Inhibitors ARRY-520 commentary on multiple myeloma

by LibbyC on Fri Dec 14, 2012 7:38 am

Thanks Suzierose for the post, it is important to be aware of new drugs and treatment regimens. Options are indeed the name of the game.