When I told my aunt(father's sister and now 93) about my multiple myeloma, she said blood diseases run in the family. She has a condition called Myeloproliferative disorder*. Her sister who died about 20 years ago of a stroke had the same disease. My living aunt has abnormal white blood cells and my deceased aunt had abnormal red blood cells. My father, who died 10 years ago from a stroke, did not have the disease but did have anemia.
I have no idea if this information is relevant but thought I would just put it out there.
John
*Definition that I found on a cancer site:
Myeloproliferative disorders are a group of slow-growing blood cancers, including chronic myelogenous leukemia, in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.
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johnk - Name: John Kavanagh
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: February 2nd, 2012
- Age at diagnosis: 61
Re: Possible genetic connection
Hello from the rainy NW !
The term "myeloproliferative disorders" refers to a group of blood cancers that includes chronic myelogenous leukemia, essential thrombocytopenia, myelofibrosis and polycythemia vera. These diseases are not related to myeloma and having a family member who has one of these diseases does not increase ones risk for getting multiple myeloma.
Best of luck in your journey with myeloma.
.
The term "myeloproliferative disorders" refers to a group of blood cancers that includes chronic myelogenous leukemia, essential thrombocytopenia, myelofibrosis and polycythemia vera. These diseases are not related to myeloma and having a family member who has one of these diseases does not increase ones risk for getting multiple myeloma.
Best of luck in your journey with myeloma.
.
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
Re: Possible genetic connection
Dr. Libby,
Thanks for the reply and clarification. I was all set to warn family members.
John
Thanks for the reply and clarification. I was all set to warn family members.
John
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johnk - Name: John Kavanagh
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: February 2nd, 2012
- Age at diagnosis: 61
Re: Possible genetic connection
Dr. Edward Libby wrote:
> Hello from the rainy NW !
> The term "myeloproliferative disorders" refers to a group of
> blood cancers that includes chronic myelogenous leukemia, essential
> thrombocytopenia, myelofibrosis and polycythemia vera. These diseases are
> not related to myeloma and having a family member who has one of these
> diseases does not increase ones risk for getting multiple myeloma.
> Best of luck in your journey with myeloma.
> .
How definitive was the study about genetic connections?
The reason I ask is that my wife's Grandfather died of Chronic Leukemia in 1964, her Father died of Non Hodgkin Lymphoma in 2009, and she was diagnosed with multiple myeloma a year ago aged 49. I have wondered how many people have had family backgrounds looked at when multiple myeloma is diagnosed in order to look at any possible genetic connection, or whether people are all told there is no genetic connection so it's just left at that. I look forward to your reply, kind regards.
> Hello from the rainy NW !
> The term "myeloproliferative disorders" refers to a group of
> blood cancers that includes chronic myelogenous leukemia, essential
> thrombocytopenia, myelofibrosis and polycythemia vera. These diseases are
> not related to myeloma and having a family member who has one of these
> diseases does not increase ones risk for getting multiple myeloma.
> Best of luck in your journey with myeloma.
> .
How definitive was the study about genetic connections?
The reason I ask is that my wife's Grandfather died of Chronic Leukemia in 1964, her Father died of Non Hodgkin Lymphoma in 2009, and she was diagnosed with multiple myeloma a year ago aged 49. I have wondered how many people have had family backgrounds looked at when multiple myeloma is diagnosed in order to look at any possible genetic connection, or whether people are all told there is no genetic connection so it's just left at that. I look forward to your reply, kind regards.
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David Cook
Re: Possible genetic connection
The topic is not being ignored by scientists though. Research is ongoing.
See the links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716021/
Two representative studies I found on the NCI website include:
#1. Prospective Study of Clinical, Laboratory, Genetic, and Epidemiologic Characterization of Individuals and Families at High Risk for Hematologic Cancers. Protocol IDs NCI-02-C-0210
and NCT00052234. This study is being conducted at the NCI in Maryland and 3000 patients will be studied.
#2. Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
Protocl IDs: 00-069 NCT00582621. This study is being conducted at the Memorial Sloan-Kettering Cancer Center in New York.
Good question....thanks!
See the links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716021/
Two representative studies I found on the NCI website include:
#1. Prospective Study of Clinical, Laboratory, Genetic, and Epidemiologic Characterization of Individuals and Families at High Risk for Hematologic Cancers. Protocol IDs NCI-02-C-0210
and NCT00052234. This study is being conducted at the NCI in Maryland and 3000 patients will be studied.
#2. Ascertainment of Families for Genetic Studies of Familial Lymphoproliferative Disorders
Protocl IDs: 00-069 NCT00582621. This study is being conducted at the Memorial Sloan-Kettering Cancer Center in New York.
Good question....thanks!
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
Re: Possible genetic connection
David,
Thanks for keeping this topic alive.
John
Thanks for keeping this topic alive.
John
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johnk - Name: John Kavanagh
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: February 2nd, 2012
- Age at diagnosis: 61
Re: Possible genetic connection
Dr Libby,
Thanks for the reply, I am sure there will be a lot of interest in the result of the research.
John,
No need for thanks, all the topics on here are interesting, I'm learning so much from everyone else's questions!
Thanks for the reply, I am sure there will be a lot of interest in the result of the research.
John,
No need for thanks, all the topics on here are interesting, I'm learning so much from everyone else's questions!
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David Cook
7 posts
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