[Beacon Staff]

Selinexor + dexamethasone - initial trial results

by Beacon Staff on Fri Jun 13, 2014 8:03 am

There was a press release put out earlier today by Karyopharm, the company that is developing the potential new myeloma therapy known as Selinexor. This drug also has been known in the past at KPT-330. The press release discusses updated results from a very small trial (8 patients thus far) testing Selinexor in combination with dexamethasone in relapsed myeloma patients.

The press release can be viewed here:

https://myelomabeacon.org/pr/2014/06/13/selinexor-multiple-myeloma-eha-2014/

Patients in the study had a median of 5.5 previous therapies. The overall response rate to the combination is 50 percent thus far. The clinical benefit rate, which is the overall response rate plus the percent of patients achieving a minor response or stable disease, is 75 percent.

One patient achieved a stringent complete response.

These are promising results. You don't often see an overall response rate of 50 percent in relapsed myeloma patients with so many previous lines of therapy.

That said, only eight patients have been tested thus far with the Selinexor-dex combination, so it's too early to draw any firm conclusions about how active this combination is.

There were two Selinexor abstracts related to myeloma presented at the ASH 2013 meeting in December. They were:

Effects Of Inhibition Of XPO1/CRM1-Dependent Nuclear Export By Selinexor (KPT-330), Alone and In Combination With Carfilzomib (CFZ), On Apoptosis and Autophagy In Multiple Myeloma (multiple myeloma)

Anti Tumor Activity Of Selinexor (KPT-330), A First-In-Class Oral Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist In Patients (pts) With Relapsed / Refractory Multiple Myeloma (multiple myeloma) Or Waldenstrom’s Macroglobulinemia (WM)

[Igor]

Re: Selinexor + dexamethasone - initial trial results

by Igor on Sat Jun 14, 2014 5:46 am

Than you very much for your report! Very exciting news!!!

[Beacon Staff]

Re: Selinexor + dexamethasone - initial trial results

by Beacon Staff on Sat Jun 14, 2014 7:59 am

To give a sense of the impact this news had yesterday, the stock of Karyopharm, the company developing Selinexor, went up over 90 percent in price yesterday. The stock closed on Thursday afternoon at a price of about $25, and, by Friday afternoon at the closing bell, it was at $47 per share.

The market value of the company changed from about $750 million to $1.4 billion in one day.

Karyopharm3.png (28.28 KiB) Viewed 1212 times

[BeatMyeloma]

Re: Selinexor + dexamethasone - initial trial results

by BeatMyeloma on Tue Oct 20, 2015 2:02 pm

My mother is going on a trial of selinexor-dex for quad-refractory myeloma. Hopefully her results will be just as good as this first cohort!

[TerryH]

Re: Selinexor + dexamethasone - initial trial results

by TerryH on Tue Oct 20, 2015 6:24 pm

I hope your mother responds well to the selinexor-dex combination, BM. Thanks for letting us know that she'll be taking part in the trial.

[Little Monkey]

Re: Selinexor + dexamethasone - initial trial results

by Little Monkey on Tue Oct 20, 2015 6:28 pm

BeatMyeloma, I noticed your mom's first treatment was CyBorD, are you in Canada?

[BeatMyeloma]

Re: Selinexor + dexamethasone - initial trial results

by BeatMyeloma on Tue Oct 20, 2015 9:23 pm

Hi LittleMonkey,

No, we're in the US.

[BeatMyeloma]

Re: Selinexor + dexamethasone - initial trial results

by BeatMyeloma on Wed Oct 21, 2015 3:13 pm

Thank you TerryH! We're about ready for some success, I can tell you that! Mom will have another drain of her myelomatous ascites on Monday and hopefully start the trial that day. Obviously our first hope is that it works at all, but also that it will work for a while and that the side effects are tolerable. I will keep the forum posted!