How was the standard determined?
Why not 5 cycles or 12 cycles?
If CR or sCR are achieved in 6 cycles does therapy still continue?
If so what is the medical rationale?
Have 8 cycles been shown to increase overall survival?
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Re: Why are Eight Cycles the Norm for multiple myeloma chemo
This is a great question to which there is no satisfactory scientific answer. The optimal number of cycles for a particular regimen is not a question that has been addressed adequately in phase 3 trials to date. In large part, the cycle duration for a particular regimen is empiric, but based on a recognition that adequate disease control is necessary but cumulative toxicities of therapy frequently make it difficult to move beyond a particular number of cycles. The number of cycles in myeloma regimens varies quite broadly depending on whether a transplant is considered as an option, toxicities of therapy, etc.
Pete V.
Pete V.
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Dr. Peter Voorhees - Name: Peter Voorhees, M.D.
Beacon Medical Advisor
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