EHA 2015 Multiple Myeloma Abstracts –
Poster Presentations June 12
There will be two sessions at the 2015 European Hematology Association (EHA) meeting where posters focused on multiple myeloma-related research will be displayed and visitors to the poster hall can speak with one of the poster's authors. The first session will be in the late afternoon on Friday, June 12. The second will be in the late afternoon on Saturday, June 13.
Listed below are titles and links to the abstracts for the myeloma-related posters that will be on display on Friday, June 12. A separate list is available for posters to be presented on Saturday, June 13. Both lists include transplantation-related posters with either direct or indirect relevance to multiple myeloma.
The Beacon also has a list of EHA 2015 of myeloma-related "e-posters," and a list of all myeloma-related oral presentations.
Links to PDF files containing posters will be added to entries in this list as those files are made available to The Beacon courtesy of the EHA presenters.
| Session | Multiple Myeloma - Biology 1 |
| Type | Poster Presentations |
| Time | Friday June 12, 5:15 PM - 6:45 PM |
| Location | Poster Area (Hall C) |
| Chair | G Tonon |
P258 - A Comprehensive Genome-Wide Copy Number Alterations (CNAs) Analysis Of Homogeneously Treated, Newly Diagnosed Multiple Myeloma (MM) Patients
Carolina Terragna, Flores Angela Dico, Marina Martello, Vincenzo Callea, Gioacchino Catania, Tonino Spadano, Tommaso Caravita di Toritto, Giulia Marzocchi, Enrica Borsi, Annamaria Cafro, Angelo D. Palmas, Silvestro Volpe, Marcello Prete, Ernesto Vigna, Luca De Rosa, Claudia Cellini, Pieter Sonneveld, Antonio Palumbo, Michele Cavo (abstract)
P259 - Relationship Between Inhibition Profile Of Β1, Β2 And Β5 Proteasome Subunits And Cytotoxic Activity Of Proteasome Inhibitors In Multiple Myeloma
Andrej Besse, Marianne Kraus, Jurgen Bader, Lenka Besse, Bo-Tao Xin, Gerjan de Bruin, Herman S. Overkleeft, Christoph Driessen (abstract)
P261 - S1P Modulator FTY720 Targets Osteoclastogenesis In CXCR4-Based Multiple Myeloma Systemic Xenograft Model
Katia Beider, Evgenia Rosenberg, Hanna Bitner, Avichai Shimoni, Merav Leiba, Maya Koren-Michowitz, Shiri Klein, Dvora Olam, Lola Weiss, Michal Abraham, Amnon Peled, Arnon Nagler (abstract)
P262 - PTC-209, A Transcriptional Small Molecule Inhibitor Of BMI-1, Demonstrates Potent Anti-Myeloma Activity In Vitro
Arnold Bolomsky, Heinz Ludwig (abstract)
P263 - Pomalidomide Enhances The Activation Of Anti-Myeloma Specific T Cells In Healthy Donors And Multiple Myeloma Patients
Jingying Dai, Brigitte Neuber, Melanie Engelhardt, Sergej Medenhoff, Michael Schmitt, Anthony D Ho, Hartmut Goldschmidt, Michael Hundemer (abstract)
P264 - Lenalidomide Increases Human Dendritic Cell Maturation Modulating Both Monocyte Differentiation And Mesenchymal Stromal Cell Inhibitory Properties
Federica Costa, Marina Bolzoni, Rosanna Vescovini, Denise Toscani, Fabrizio Accardi, Paola Storti, Valentina Marchica, Daniela Guasco, Benedetta Dalla Palma, Franco Aversa, Nicola Giuliani (abstract)
P265 - P21-Activated Kinase 4 (PAK4) Regulates Multiple Myeloma (MM) Cell Growth And Survival By Modulation Of Critical Transcriptional Pathways: Therapeutic Application Of PAK4 Allosteric Inhibitors
Maria Teresa Fulciniti, Stefania Oliva, Nicola Amodio, Aldo Roccaro, Rajya Lakshmi Bandi, Huynh Daisy, Antonia Cagnetta, William Senapedis, Erkan Baloglu, Kenneth C. Anderson, Irene Ghobrial, Nikhil C. Munshi (abstract)
P266 - Bone Marrow-Mediated Drug Resistance Is Promoted By Jagged-Induced Notch Pathway In Multiple Myeloma
Silvia Garavelli, Elisa Lazzari, Michela Colombo, Alessandro Paoli, Natalia Platonova, Serena Galletti, Katia Todoerti, Antonino Neri, Raffaella Chiaramonte (abstract)
| Session | Multiple Myeloma - Clinical 1 |
| Type | Poster Presentation |
| Time | Friday June 12, 5:15 PM - 6:45 PM |
| Location | Poster Area (Hall C) |
| Chair | Xavier Leleu |
P267 - FDG-PET/CT Focal Lesions In The Absence Of Osteolyses As A New Marker Of Progression Of Smoldering Multiple Myeloma Into Symptomatic Disease
Elena Zamagni, Cristina Nanni, Francesca Gay, Annalisa Pezzi, Francesca Patriarca, Marilena Bellò, Ilaria Rambaldi, Paola Tacchetti, Jens Hillengass, Barbara Gamberi, Lucia Pantani, Valeria Magarotto, Annibale Versari, Massimo Offidani, Beatrice Zannetti, Francesca Carobolante, Massimo Menga, Giovanna Mansueto, Emanuela Englaro, Katia Mancuso, Antonia Dimitrakopoulou-Strauss, Serena Rocchi, Nassim Fard, Giulia Marzocchi, Antonio Palumbo, Stefano Fanti, Michele Cavo (abstract)
P268 - Analysis Of Outcomes By Response For Patients With Relapsed Or Relapsed And Refractory Multiple Myeloma In The Phase 3 PANORAMA 1 Study Of Panobinostat Or Placebo Plus Bortezomib And Dexamethasone
Philippe Moreau, Jesus San-Miguel, Vania Hungria, Sung-Soo Yoon, Meral Beksac, Meletios Dimopoulos, Ashraf Elghandour, Wieslaw Jedrzejczak, Andreas Guenther, Thanyaphong Na Nakorn, Noppadol Siritanaratkul, Robert Schlossman, Jian Hou, Sagar Lonial, Jae Hoon Lee, Hermann Einsele, Monika Sopala, Bourras-Rezki Bengoudifa, Claudia Corrado, Paul Richardson (abstract)
P269 - Weekly Carfilzomib With Dexamethasone For Patients With Relapsed Or Refractory Multiple Myeloma: Updated Results From The Phase 1/2 Study CHAMPION-1 (NCT01677858)
James Berenson, Alan Cartmell, Roger M. Lyons, Wael Harb, Dimitrios Tzachanis, Ralph Boccia, Robert M. Rifkin, Priti Patel, Sandra Dixon, Jesus Berdeja (abstract)
P270 - Early Mortality In Elderly Newly Diagnosed Multiple Myeloma Patients Treated With Novel Agents: A Pooled Analysis Of Two Large Randomized Phase III Trials
Alessandra Larocca, Sara Bringhen, Maria Teresa Petrucci, Massimo Offidani, Lorenzo De Paoli, Giuseppe Pietrantuono, Luca Baldini, Tommasina Guglielmelli, Valeria Magarotto, Maria Cantonetti, Andrea Nozza, Andrea Evangelista, Stefano Spada, Nicola Giuliani, Mariella Grasso, Roberto Marasca, Vittorio Montefusco, Iolanda Vincelli, Fortunato Morabito, Chiara Nozzoli, Luca De Rosa, Maide Cavalli, Angelo Michele Carella, Roman Hajek, Mario Boccadoro, Antonio Palumbo (abstract)
P271 - Maintenance Therapy With Lenalidomide In Elderly Patients With Newly Diagnosed Multiple Myeloma: A Post-Hoc Analysis Of The EMN01 Trial
Valeria Magarotto, Sara Bringhen, Massimo Offidani, Giulia Benevolo, Francesca Patriarca, Carmela Palladino, Antonietta Pia Falcone, Davide Rossi, Oreste Villani, Caterina Musolino, Concetta Conticello, Stefano Pulini, Paola Omedè, Renato Zambello, Tommasina Guglielmelli, Antonio Ledda, Anna Marina Liberati, Roman Hajek, Mario Boccadoro, Antonio Palumbo (abstract)
P272 - Outcomes For Older Patients With Refractory Or Relapsed And Refractory Multiple Myeloma Treated With Pomalidomide + Low-Dose Dexamethasone In The STRATUS (MM-010) Trial, A Single-Arm, Phase 3b Study
Antonio Palumbo, Philippe Moreau, Meletios A Dimopoulos, Paolo Corradini, Michele Cavo, Michel Delforge, Katja C Weisel, Hartmut Goldschmidt, Mario Petrini, Martin F Kaiser, Ana Slaughter, Mathew Simcock, Jennifer Herring, Teresa Peluso, Lars Sternas, Mohamed Zaki, Enrique M Ocio (abstract)
P273 - The STRATUS (MM-010) Trial: A Single-Arm, Phase 3b Study Evaluating Safety And Efficacy Of Pomalidomide + Low-Dose Dexamethasone In Patients With Refractory Or Relapsed And Refractory Multiple Myeloma
Meletios A Dimopoulos, Antonio Palumbo, Paolo Corradini, Michele Cavo, Michel Delforge, Katja Weisel, Enrique Ocio, Francesco Di Raimondo, Albert Oriol, Mathew Simcock, Neil Miller, Ana Slaughter, Teresa Peluso, Lars Sternas, Mohamed Zaki, Philippe Moreau (abstract)
P274 - Impact Of Renal Impairment On Outcomes After Treatment With Lenalidomide And Low-Dose Dexamethasone In Patients With Newly Diagnosed Multiple Myeloma: FIRST Trial Results
Meletios Dimopoulos, Matthew Cheung, Murielle Roussel, Ting Liu, Barbara Gamberi, Brigitte Kolb, Hans Günter Derigs, HyeonSeok Eom, Karim Belhadj, Pascal Lenain, Richard van der Jagt, Sophie Rigaudeau, Rachel Hall, Arnaud Jaccard, Axel Tosikyan, Lionel Karlin, William Bensinger, Rik Schots, Guang Chen, Jennifer Marek, Annette Ervin-Haynes, Thierry Facon (abstract)
P275 - An Open-Label, Multicenter, Phase 1b Study Of Daratumumab In Combination With Pomalidomide-Dexamethasone And With Backbone Regimens In Patients With Multiple Myeloma
Maria-Victoria Mateos, Philippe Moreau, Raymond Comenzo, Joan Bladé, Lotfi Benboubker, Javier de la Rubia, Thierry Facon, Joseph Fay, Xiang Qin, Tara Masterson, Jordan Schecter, Tahamtan Ahmadi, Jesus San-Miguel (abstract)
P276 - Outcomes Of Patients With Primary Refractory Multiple Myeloma In The Era Of Novel Therapies
Neil Majithia, S. Vincent Rajkumar, Angela Dispenzieri, Morie Gertz, Martha Lacy, Buadi Francis, Suzanne Hayman, David Dingli, Lisa Hwa, John Lust, Stephen Russell, Prashant Kapoor, Ronald Go, Robert Kyle, Shaji Kumar (abstract)
| Session | Multiple Myeloma - Clinical 2 |
| Type | Poster Presentations |
| Time | Friday June 12, 5:15 PM - 6:45 PM |
| Location | Poster Area (Hall C) |
| Chair | Efstathios Kastritis |
P277 - Assessing The Benefit Of Continuous Treatment In The FIRST Trial (MM-020): Impact Of Response In Patients With Transplant-Ineligible Newly Diagnosed Multiple Myeloma
Nizar Bahlis, Alessandro Corso, Lars-Olof Mügge, Zhi-Xiang Shen, Pierre Desjardins, Anne Marie Stoppa, Olivier Decaux, Thierry de Revel, Miguel Granell, Gérald Marit, Hareth Nahi, Hilde Demuynck, Shang-Yi Huang, Supratik Basu, Annette Ervin-Haynes, Nicolas Leupin, Jennifer Marek, Guang Chen, Thierry Facon (abstract)
P278 - Lack Of Response Improvement Beyond Day +100 After Autologous Stem Cell Transplantation In Absence Of Maintenance Therapy In Multiple Myeloma
Carlos Fernández De Larrea, Julio Dávila, Ignacio Isola, Enrique M. Ocio, Laura Rosiñol, Ramón García-Sanz, Mª Teresa Cibeira, Natalia Tovar, Montserrat Rovira, María Victoria Mateos, Jesús San Miguel, Joan Bladé (abstract)
P279 - Ricolinostat (ACY-1215) The First Selective HDAC6 Inhibitor In Combination With Pomalidomide And Dexamethasone In Patients With Relapsed & Refractory Multiple Myeloma: Phase 1b & Early Phase 2 Results
Noopur Raje, William Bensinger, Daniel Lebovic, Sagar Lonial, Sundar Jagannath, Carlos Acre-Lara, Ashley Rosko, Wael Harb, Nizar Bahlis, Jeff Supko, David Tamang, Simon Jones, Catherine Wheeler, Paul Richardson (abstract)
P280 - Progression-Free Survival 2 (PFS2) Is The Most Significant Prognostic Factor Of Long-Term Survival In The Era Of Novel Agents: A Single Greek Myeloma Center Experience
Eirini Katodritou, Sofia Papadaki, Genovefa Polychronidou, Nikos Spyridis, Nikos Karabatzakis, Aikaterini Pentidou, Silia Palaska, Kyriaki Kokoviadou, Efthimia Vlachaki, Dimitra Markala, Efi Yiannaki, Vasilios Perifanis, Evgenia Verrou, Vassiliki Gastari, Pavlina Konstantinidou, Evangelos Terpos (abstract)
P281 - Obesity And Risk Of Monoclonal Gammopathy Of Undetermined Significance: A Population-Based Study
Marianna Thordardottir, Ebba Lindqvist, Sigrun Helga Lund, Rene Costello, Debra Burton, Neha Korde, Sham Mailankody, Gudny Eiriksdottir, Lenore J Launer, Vilmundur Gudnason, Tamara B Harris, Ola Landgren, Sigurdur Y Kristinsson (abstract)
P282 - Post Autologous Stem Cell Transplantation Maintenance In Multiple Myeloma. Single Center Experience Of 18 Years: A Marked Survival Advantage With Interferon
Gergely Varga, Dóra Lévai, Péter Reményi, Gábor Mikala, Marienn Réti, László Gopcsa, Árpád Bátai, Zoltán Csukly, Lilla Lengyel, Éva Torbágyi, Anikó Barta, János Fábián, Tamás Masszi (abstract)
P283 - Whole Body Diffusion Weighted MRI Scanning In Patients With Myeloma. Incidental Findings - The Royal Marsden Experience
Anita Wale, Charlotte Pawlyn, Martin Kaiser, Christina Messiou (abstract)
P284 - Patterns Of Total Cost Of Care By Age Group For Patients With Newly Diagnosed Multiple Myeloma (MM)
Steven Arikian, Gary Binder, Craig J Gibson, Henry Hu, Yasir Nagarwala, Mohamad Hussein, Frank A Corvino, Andy Surinach, Saad Usmani (abstract; poster [PDF] courtesy of Dr. Usmani)
P285 - Encouraging Preliminary Data In Ongoing Open-label Phase 1/2 Study Of Safety And Efficacy Of Melflufen And Dexamethasone For Patients With Relapsed And Relapsed-Refractory Multiple Myeloma
Valeria Magarotto, Pieter Sonneveld, Peter Voorhees, Claudia Paba-Prada, Torben Plesner, Ulf-Henrik Mellqvist, Catriona Byrne, Johan Harmenberg, Eva Nordström, Antonio Palumbo, Paul Richardson (abstract; poster [PDF] courtesy of Dr. Magarotto)
P286 - Analysis Of Patients With Refractory Or Relapsed And Refractory Multiple Myeloma And Renal Impairment Treated With Pomalidomide + Low-Dose Dexamethasone In The Phase 3b STRATUS Trial (MM-010)
Katja Weisel, Meletios A Dimopoulos, Antonio Palumbo, Paolo Corradini, Michele Cavo, Michel Delforge, Enrique M Ocio, Angelo Vacca, Markus Hansson, Maria Blanchard, Neil Milller, Teresa Peluso, Lars Sternas, Mohamed Zaki, Philippe Moreau (abstract; poster [PDF] courtesy of Dr. Weisel)
| Session | Multiple Myeloma - Clinical 5 |
| Type | Poster Presentations |
| Time | Friday June 12, 5:15 PM - 6:45 PM |
| Location | Poster Area (Hall C) |
| Chair | Arnon Nagler |
P287 - Prognostic Value And Usefulness Of Serum-Free-Light-Chains-Ratio (sFLCr) And Serum Heavy-Light-Chains-Ratio (sHLCr) In Symptomatic Multiple Myeloma In The Context Of Three GEM/PETHEMA Clinical Trials
Lucia Lopez-Anglada, Cecilia Cueto-Felgueroso, Maria Victoria Mateos, Laura Rosiñol, Albert Oriol, Ana Isabel Teruel, Ana Lopez de la Guia, Enrique Bengoechea, Luis Palomera, Felipe de Arriba, Jose Mariano Hernandez, Miquel Granell, Francisco Javier Peñalver, Ramón García-Sanz, Juan Besalduch, Yolanda Gonzalez, Rafael Benigno Martinez, Miguel Teodoro Hernandez, Norma C Gutierrez, Paloma Puerta, Joan Blade, Jesus San Miguel, Juan Jose Lahuerta, Joaquin Martinez-Lopez (abstract)
P289 - Venetoclax (ABT-199/GDC-0199) In Combination With Bortezomib And Dexamethasone In Relapsed/Refractory Multiple Myeloma : Phase 1b Results
Philippe Moreau, Asher Alban Chanan-Khan, Andrew Roberts, Amit Agarwal, Thierry Facon, Daniel Lebovic, Cyrille Touzeau, David Darden, Lura Morris, Jeremy Ross, Ahmed Salem, Wijith Munasinghe, Ming Zhu, Joel Leverson, Sari Enschede, Rod Humerickhouse, Simon Harrison (abstract)
P290 - Retrospective Refining Of Diagnosis In 286 MGUS And SMM Patients According To The Updated IMWG Criteria. Clinical Implications
Marie-Christine Kyrtsonis, Eftychia Nikolaou, Tatiana Tzenou, Vasiliki Bartzis, Aikaterini Bitsani, Sotiria Kotsanti, Maria Dimou, Theodoros Iliakis, Maria Angelopoulou, Theodoros Vassilakopoulos, Panayiotis Panayiotidis (abstract)
P291 - Is A Deep Response The Key To Successful Treatment Of Multiple Myeloma?
Johan Liwing, Bart M.S. Heeg, Sigrid Karstorp, Maarten Postma, Raija Silvennoinen, Mervi Putkonen, Pekka Anttila, Kari Remes, Niels Abildgaard, Anders Waage, Hareth Nahi (abstract)
P292 - Family History Of Lymphoproliferative Disease Associated With A Superior Survival In Multiple Myeloma: A Population-Based Study
Kristrún Aradóttir, Sigrún Helga Lund, Magnus Björkholm, Lynn R Goldin, Ingemar Turesson, Ola Landgren, Sigurður Yngvi Kristinsson (abstract)
P293 - Parental Longevity And Survival In Patients With Multiple Myeloma And MGUS
Ingigerdur Solveig Sverrisdottir, Sigrun Helga Lund, Ingemar Turesson, Magnus Björkholm, Lynn R Goldin, Ola Landgren, Sigurdur Yngvi Kristinsson (abstract)
P294 - Serum B-Cell Maturation Antigen Is A Novel Prognostic Indicator For Multiple Myeloma Patients And Correlates With Clinical Status And Survival
James Berenson, Michael Ghermezi, Suzie Vardanyan, Nika Harutyunyan, Maya Spitzer, Jillian Gottlieb, Ariana Berenson, Claudia Andreu-Vieyra, Mingjie Li, Cathy Wang, Eric Sanchez, Regina Swift, Haiming Chen (abstract)
P295 - The Notch Ligands Jagged1 And 2 Are A Potential Therapeutic Target In Multiple Myeloma-Associated Bone Disease
Michela Colombo, Silvia Garavelli, Katia Todoerti, Alessandro Paoli, Natalia Platonova, Serena Galletti, Antonino Neri, Raffaella Chiaramonte (abstract)
Late Breaking Poster Abstract
LB297 - Significant Impact Of Minimal Residual Disease (MRD) Status On Survival Outcomes In Patients With Multiple Myeloma (MM) Who Achieve Complete Response (CR): A Meta-Analysis
Nikhil Munshi, Herve Avet-Loiseau, Andy Rawstron, Roger Owen, Anjan Thakurta, Paul Sherrington, Anna Georgieva, Kenneth Anderson, Walter Gregory (abstract)
| Session | Stem Cell Transplantation - Clinical 1 |
| Type | Poster Presentations |
| Time | Friday June 12, 5:15 PM - 6:45 PM |
| Location | Poster Area (Hall C) |
| Chair | A Elmaagacli |
P337 - Supportive Care And Infectious Complications In Cord Blood And Haploidentical Stem Cell Transplantation In Adults With High Risk Hematologic Diseases
Jean Elcheikh, Roberto Crocchiolo, Andrea Vai, Sabine Furst, Stefania Bramanti, Barbara Sarina, Angela Granata, Raynier Devillier, Catherine Faucher, Bilal Mohty, Samia Harbi, Reda Bouabdallah, Norbert Vey, Armando Santoro, Christian Chabannon, Pierre-Jean Weiller, Luca Castagna, Didier Blaise (abstract)
P338 - Augmented Conditioning With Targeted Molecular Radiotherapy Prior To Autologous Stem Cell Transplantation In Myeloma: Results Of A Phase Ii Randomised Control Trial With Improved Cr Rate Post ASCT
Kim Orchard, Stephen MacKinnon, Jon Langford, Ronjon Chakraverty, Deborah Richardson, Matthew Guy, James Thom, Paul Lloyd-Evans, Matthew Jenner, Tom Maishman, Kelly Cozens, Louise Stanton, Ann-Marie Quigley, Daniel McCool, Pei-San Chan, Caspar Wickham, Peter Johnson (abstract)
P339 - Allogeneic Stem Cell Transplantation Recipients Requiring Intensive Care: Delay Between Organ Dysfunction And Referral To The Intensive Care Unit And Time Spent On Organ Support Impact Survival
Corentin Orvain, Francois Beloncle, Sylvain Thépot, Achille Kouatchet, Sylvie Francois, Philippe Guardiola, Anne Corby, Pierre Asfar, Mathilde Hunault-Berger, Norbert Ifrah, Aline Schmidt-Tanguy (abstract)
P344 - Updated Results Of The Mayo Clinic Risk Adapted Algorithm For Peripheral Blood Stem Cell Mobilization Utilizing G-CSF And Plerixafor
Raina Ferzoco, Ivana Micallef, Jeffrey Winters, Stephen Ansell, Francis Buadi, David Dingli, Angela Dispenzieri, Dennis Gastineau, Morie Gertz, Shahrukh Hashmi, Suzanne Hayman, William Hogan, David Inwards, Patrick Johnston, Prashant Kapoor, Martha Lacy, Mark Litzow, Mrinal Patnaik, Luis Porrata, Shaji Kumar (abstract)
P345 - Post-Transplant Cyclophosphamide (PT-Cy) Is Effective To Prevent GVHD After T-Cell Replete Haploidentical Peripheral Blood Stem Cell Transplantation (Haplo-SCT)
Angela Granata, Sabine Fürst, Luca Castagna, Raynier Devillier, Jean El Cheikh, Samia Harbi, Catherine Faucher, Aude Charbonnier, Anne Marie Stoppa, Therese Aurran, Boris Calmels, Claude Lemarie, Christophe Picard, Roberto Crocchiolo, Reda Bouhabdallah, Christian Chabannon, Norbert Vey, Didier Blaise (abstract)
| Session | Stem Cell Transplantation - Clinical 3 |
| Type | Poster Presentations |
| Time | Friday June 12, 5:15 PM - 6:45 PM |
| Location | Poster Area (Hall C) |
| Chair | Hakan Goker |
P354 - Treatment Of Chronic Graft Versus Host Disease With A Combination Of B-Cell Depletion And Tyrosine Kinase Inhibition, Preliminary Results
Lotte Van Der Wagen, Liane te Boome, Marieke Schoordijk, Ellen Meijer, Juergen Kuball (abstract)
