EHA 2015 Multiple Myeloma Abstracts –
Oral Presentations
Oral presentations related to multiple myeloma will take place on three main days of the 2015 European Hematology Association (EHA) annual meeting – Friday, June 12; Saturday, June 13; and Sunday, June 14.
The list below contains the titles and authors of all multiple myeloma oral presentations at EHA 2015. Presenter names are in bold.
The list is organized in chronological order by session. Each entry in the list also includes a link to the full text of the relevant abstract at the EHA website.
Also included in the list are a selection of presentations to be given during sessions focused on stem cell transplantation. Some of these presentations are directly myeloma-related. Others have an admittedly more indirect relationship to multiple myeloma.
Links to PDF files containing presentation slides will be added to entries in this list as those files are made available to The Beacon courtesy of the EHA presenters.
Please note that this list does not include presentations that will be given during education sessions, symposia, or debates. A separate list with many of those presentations is being prepared.
The Beacon also has three lists of the myeloma-related posters from the 2015 EHA meeting. There is one list for the posters to be presented on Friday, June 12; a second list for the posters to be presented on Saturday, June 13; and a third list for myeloma-related e-posters.
| Session | Multiple Myeloma: Clinical Studies 1 |
| Type | Oral Presentation Session |
| Time | Friday June 12, 11:30 AM to 12:45 PM |
| Location | Room A2+3 |
| Chairs | A Spencer and M Cavo |
S101 - Improved Overall Survival With Autologous Transplantation vs Cyclophosphamide-Lenalidomide-Dexamethasone In Newly Diagnosed Myeloma: A Phase 3 Trial
11:30 AM - 11:45 AM
Francesca Gay, Mariella Genuardi, Roman Hajek, Maria Teresa Petrucci, Ludek Pour, Antonietta Pia Falcone, Massimo Offidani, Francesca Patriarca, Paolo Corradini, Milena Gilestro, Norbert Pescosta, Angelo Michele Carella, Paola Finsinger, Anna Marina Liberati, Daniela Petrò, Stefano Pulini, Stefania Oliva, Francesco Di Raimondo, Andrew Spencer, Mario Boccadoro, Antonio Palumbo (abstract, presentation slides [PDF] courtesy of Dr. Gay)
S102 - Subgroup Analysis By Prior Treatment Among Patients With Relapsed Or Relapsed And Refractory Multiple Myeloma In The PANORAMA 1 Study Of Panobinostat Or Placebo Plus Bortezomib And Dexamethasone
11:45 AM - 12:00 PM
Hermann Einsele, Paul Richardson, Vania Hungria, Sung-Soo Yoon, Meral Beksac, Meletios Dimopoulos, Ashraf Elghandour, Wieslaw Jedrzejczak, Andreas Guenther, Thanyaphong Na Nakorn, Noppadol Siritanaratkul, Robert Schlossman, Jian Hou, Philippe Moreau, Sagar Lonial, Jae Hoon Lee, Monika Sopala, Bourras-Rezki Bengoudifa, Claudia Corrado, Jesus San-Miguel (abstract)
S103 - A Randomized, Open-Label, Phase 2 Study Of Bortezomib And Dexamethasone With Or Without Elotuzumab In Patients With Relapsed/Refractory Multiple Myeloma
12:00 PM - 12:15 PM
Andrzej Jakubowiak, Massimo Offidani, Brigitte Pégourie, Javier De La Rubia, Laurent Garderet, Kamel Laribi, Alberto Bosi, Roberto Marasca, Jacob Laubach, Ann Mohrbacher, Angelo Michele Carella, Anil K. Singhal, L. Claire Tsao, Mark Lynch, Eric Bleickardt, Ying-Ming Jou, Antonio Palumbo (abstract)
S104 - NEOD001 Demonstrates Cardiac And Renal Biomarker Responses In A Phase 1/2 Study In Patients With AL Amyloidosis And Persistent Organ Dysfunction
12:15 PM - 12:30 PM
Michaela Liedtke, Heather Landau, Ray Comenzo, David Seldin, Brendan Weiss, Jeffrey Zonder, Jackie Walling, Gene Kinney, Martin Koller, Morie A. Gertz (abstract)
S105 - Updated Overall Survival Analysis Of The FIRST Study: Continuous Lenalidomide Plus Low-Dose Dexamethasone vs Melphalan, Prednisone, And Thalidomide In Patients With Newly Diagnosed Multiple Myeloma
12:30 PM - 12:45 PM
Thierry Facon, Meletios A Dimopoulos, Cyrille Hulin, Lotfi Benboubker, Andrew Belch, Heinz Ludwig, Antonio Pinto, Michel Attal, Michele Cavo, Philippe Moreau, Rik Schots, Nathalie Meuleman, Katia Weisel, Mourad Tiab, Je-Jung Lee, Andrew Butler, Jennifer Marek, Guang Chen, Annette Ervin-Haynes, Jean Paul Fermand (abstract)
| Session | Stem Cell Transplantation – Clinical 1 |
| Type | Oral Presentation Session |
| Time | Friday June 12, 11:30 AM to 12:45 PM |
| Location | Room Lehar 1 + 2 |
| Chairs | Nigel Russell and P Corradini |
S130 - Allo-HSCT Following RIC For Elderly Patients (60 Years And Older) With Hematological Malignancies Using Unrelated Donors: A Retrospective Study Of The SFGM-TC
12:30 PM - 12:45 PM
Jean Elcheikh, Patrick Sfumato, Nathalie Fegeux, Mohamad Mohty, Stéphane Vigouroux, Ibrahim Yakoub-Agha, Gérard Socié, Jerome Cornillon, Norbert Ifrah, Jacques Olivier Bay, Mauricette Michallet, Didier Blaise, Regis Peffault De Latour (abstract)
| Session | Presidential Symposium |
| Type | Plenary Session |
| Time | Friday June 12, 3:45 PM - 5:00 PM |
| Location | Room A2+3 |
| Chairs | C Chomienne and D Grimwade |
S471 - ELOQUENT-2: A Phase 3, Randomized, Open-Label Study Of Lenalidomide / Dexamethasone With Or Without Elotuzumab In Patients With Relapsed/Refractory Multiple Myeloma
3:45 PM - 4:00 PM
Meletios Dimopoulos, Sagar Lonial, Antonio Palumbo, Darrell White, Sebastian Grosicki, Ivan Spicka, Adam Walter-Croneck, Philippe Moreau, Maria-Victoria Mateos, Hila Magen, Andrew Belch, Donna Reece, Meral Beksac, Andrew Spencer, Heather Oakervee, Masafumi Taniwaki, Christoph Röllig, Ka Lung Wu, Anil Singhal, Jesus San Miguel, Morio Matsumoto, Jessica Katz, Eric Bleickardt, Valerie Poulart, Paul Richardson (abstract)
| Session | Multiple Myeloma: Clinical Studies 2 |
| Type | Oral Presentation Session |
| Time | Saturday June 13, 11:30 AM to 12:45 PM |
| Location | Room A2+3 |
| Chairs | M Delforge and R Hajek |
S426 - Results From Two Phase 3 Studies Of Post-Transplant Bortezomib (BTZ) Consolidation vs Observation (OBS) In Patients With Newly Diagnosed Multiple Myeloma (NDMM)
11:30 AM - 11:45 AM
Hermann Einsele, Martin Vogel, Jürgen Müller, Stefan Knop, Martin Kropff, Christian Langer, Herbert Sayer, Wolfram Jung, Hannes Wandt, Florian Bassermann, Martin Gramatzki, Wolf Rösler, Wolfram Brugger, Monika Engelhardt, Thomas Fischer, Aristoteles Giagounidis, Else Heidemann, Nicolaus Kröger, Orhan Sezer, Martin Bentz, Michael Pfreundschuh, Hans Salwender, Wolf-Dieter Ludwig, Christoph Röllig, Peter Staib, Volker Runde, Christof Scheid, Helmut Ostermann, Georg Heß, Holger Hebart, Roland Repp, Christina Hart, Norbert Frickhofen, Christian Straka, Karl-Heinz Pflüger (abstract)
S427 - Effect Of Carfilzomib, Lenalidomide, And Dexamethasone vs Lenalidomide And Dexamethasone In Patients With Relapsed Multiple Myeloma By Line Of Therapy: Interim Results From The Phase 3 ASPIRE Study
11:45 AM - 12:00 PM
Meletios A. Dimopoulos, A. Keith Stewart, S. Vincent Rajkumar, Tamás Masszi, Ivan Špi?ka, Albert Oriol, Roman Hájek, Laura Rosiñol, David Siegel, Georgi G. Mihaylov, Vesselina Goranova-Marinova, Péter Rajnics, Aleksandr Suvorov, Ruben Niesvizky, Andrzej Jakubowiak, Jesus San-Miguel, Heinz Ludwig, Naseem Zojwalla, Margaret Tonda, Xinqun Yang, Philippe Moreau, Antonio Palumbo (abstract)
S428 - The Quadruplet Combination Of Carfilzomib, Cyclophosphamide, Lenalidomide, And Dexamethasone Is Safe And Well Tolerated As Induction Therapy For Newly Diagnosed, Transplant Eligible, Myeloma Patients
12:00 PM - 12:15 PM
Charlotte Pawlyn, Faith Davies, David Cairns, Corinne Collett, John Jones, Martin Kaiser, Anna Chalmers, Alina Striha, Donald Milligan, Jindriska Lindsay, Claire Chapman, David Allotey, Salim Shafeek, Kamaraj Karunanithi, Gordon Cook, Nigel Russell, Mark Drayson, Roger Owen, Walter Gregory, Graham Jackson, Gareth Morgan (abstract)
S429 - Effect Of Age On Efficacy And Safety Outcomes In Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide And Low-Dose Dexamethasone (Rd): The FIRST Trial
12:15 PM - 12:30 PM
Cyrille Hulin, Chaim Shustik, Andrew Belch, Maria Teresa Petrucci, Ulrich Dührsen, Jin Lu, Kevin Song, Philippe Rodon, Brigitte Pégourié, Laurent Garderet, Hannah Hunter, Isabelle Azais, Richard Eek, Margaret Macro, Shaker Dakhil, Vanessa Houck, Guang Chen, Annette Ervin-Haynes, Fritz Offner, Meletios A Dimopoulos, Thierry Facon (abstract)
S430 - Phase 2 Study Of Daratumumab Monotherapy In Patients With >3 Lines Of Prior Therapy Or Double Refractory Multiple Myeloma: 54767414MMY2002 (SIRIUS)
12:30 PM - 12:45 PM
Sagar Lonial, Brendan Weiss, Saad Usmani, Seema Singhal, Ajai Chari, Nizar Bahlis, Andrew Belch, Amrita Krishnan, Robert Vescio, Maria Victoria Mateos, Amitabha Mazumder, Robert Z Orlowski, Heather Sutherland, Joan Blade, Emma C Scott, Albert Oriol, Jesus Berjeda, Mecide Gharibo, Don A Stevens, Richard Le Blanc, Michael Sebag, Natalie Callander, Andrzej Jakubowiak, Darrell White, Javier de la Rubia, Steen Lisby, Huaibao Feng, Imran Khan, Clarissa Uhlar, Tahamtan Ahmadi, Peter Voorhees (abstract)
| Session | Plenary Session 1 |
| Type | Plenary Session |
| Time | Saturday June 13, 1:15 PM to 2:15 PM |
| Location | Room A2+3 |
| Chairs | C Chomienne and Richard Greil |
Iron: A Global Issue In Hematology
1:15 PM - 1:45 PM
C Camaschella
CAR-T Cells
1:45 PM - 2:15 PM
C June
| Session | Stem Cell Transplantation - Clinical 2 |
| Type | Oral Presentation Session |
| Time | Saturday June 13, 11:30 AM to 12:45 PM |
| Location | Room C2 |
| Chairs | T Ruutu and Xioa-Jun Huang |
S442 - KIR2DS4 And Its Variant KIR1D Are Associated With AGVHD, CMV And OS After Sibling Related HLA Matched Transplantation For Patients Whose Donors Belong To KIR Gene Haplotype A
11:45 AM - 12:00 PM
Xiaojin Wu, Yao Yao, Xiaojing Bao, Xiaowen Tang, Huifen Zhou, Yue Han, Chengcheng Fu, Aining Sun, Xiao (abstract)
S443 - Human Atrial Natriuretic Peptide (hANP) Therapy In The Early Phase After Allogeneic Stem Cell Transplant (Allo-SCT) Prevents Development Of Chronic Kidney Disease (CKD): Results From A Phase 2 Study
12:00 PM - 12:15 PM
Hiroaki Shimizu, Takuma Ishizaki, Nahoko Hatsumi, Satoru Takada, Akihiko Yokohama, Takayuki Saitoh, Toru Sakura, Hiroshi Handa (abstract)
S445 - Updated Results Of A Multicenter Phase I/Ib Study Of CTLA4 Blockade With Ipilimumab For Relapsed Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation
12:30 PM - 12:45 PM
Matthew S. Davids, Haesook T. Kim, Caitlin Costello, David Avigan, Yi Bin Chen, Philippe Armand, Edwin P. Alyea, Jacquelyn Hedlund, Peter McSweeney, Rebecca Liguori, Jerome Ritz, Edward D. Ball, Asad Bashey, Robert J. Soiffer (abstract)
| Session | Multiple Myeloma – Biology |
| Type | Oral Presentation Session |
| Time | Saturday June 13, 3:45 PM to 5:00 PM |
| Location | Room A2+3 |
| Chairs | M Mateos and N van de Donk |
S476 - Exome Sequencing Points To Differences In Genetic Instability Level In MGUS Compared To MM
3:45 PM - 4:00 PM
Aneta Mikulasova, Brian A. Walker, Christopher P. Wardell, Eileen M. Boyle, Marketa Wayhelova, Jan Smetana, Ludek Pour, Petr Kuglik, Roman Hajek, Gareth J. Morgan (abstract, presentation slides [PDF] courtesy of Ms. Mikulasova)
S477 - Expression Levels Of CD38 And Complement Inhibitory Proteins CD55 And CD59 Predict Response To Daratumumab In Multiple Myeloma
4:00 PM - 4:15 PM
Inger Nijhof, Amy Axel, Tine Casneuf, Tuna Mutis, Andries Bloem, Jeroen Van Velzen, Berris Van Kessel, Monique Minnema, Parul Doshi, Henk Lokhorst, Kate Sasser, Niels Van De Donk (abstract)
S478 - Additional Prognostic Value Of Circulating miR-16 Expression Over The Usual Prognostic Parameters In Multiple Myeloma Patients
4:15 PM - 4:30 PM
Alberto Rocci, Craig Hofmeister, Manuela Gambella, Roberto Passera, Andrew Stiff, Sara Bringhen, Luciano Cascione, Luciana De Luca, Don Benson, Yvonne Efebera, Davide Rossi, Silvia Gentili, Giuseppina Uccello, Roberto Ria, Giulia Benevolo, Vincenzo Callea, Valeria Magarotto, John Byrd, Mario Boccadoro, Guido Marcucci, Antonio Palumbo, Flavia Pichiorri (abstract)
S479 - Targeting Epithelial To Mesenchymal Transition (EMT) Through CXCR4 Blockade In Multiple Myeloma
4:30 PM - 4:45 PM
Aldo Roccaro, Antonio Sacco, Chin Pan, Irene Ghobrial, Jiantao Shi, Marco Chiarini, Michele Moschetta, Michelle Kuhne, Pina Cardarelli (abstract)
S480 - Overexpression Of Arginase And PROK-2 Makes Neutrophils Of Multiple Myeloma Dysfunctional And Immunosuppressive
4:45 PM - 5:00 PM
Alessandra Romano, Vittorio Simeon, Piera La Cava, Nunziatina Laura Parrinello, Alessia La Fauci, Calogero Vetro, Daniele Tibullo, Cesarina Giallongo, Maide Cavalli, Annalisa Chiarenza, Concetta Conticello, Pellegrino Musto, Frencesco Di Raimondo (abstract)
| Session | Stem Cell Transplantation – Experimental |
| Type | Oral Presentation Session |
| Time | Saturday June 13, 3:45 PM to 5:00 PM |
| Location | Room Lehar 3+4 |
| Chairs | N Kröger and T Lapidot |
S493 - miR-153-3p, A New Bio-Target, Is Involved In The Pathogenesis Of Acute Graft-Versus-Host Disease Through The Regulation Of Indoleamine-2,3-Dioxygenase
4:15 PM - 4:30 PM
Xiaosu Zhao, Yinuo Wang, Meng Lv, Hongxue Luo, Hongyu Zhang, Jun Wan, Xiaojun Huang (abstract)
S494 - Immunosuppression By Mesenchymal Stromal Cells Derived From Human Induced Pluripotent Stem Cells : Evaluation In An aGVHD Model
4:30 PM - 4:45 PM
Clémence Roux, Gaelle Saviane, Gihen Dhib, Jonathan Pini, Pierre-Simon Rohrlich, Abdel Wakkach, Claudine Blin, Matthieu Rouleau (abstract)
S495 - In Vitro-Generated Myeloid-Derived Suppressor Cells (MDSC) Prevent Murine Graft-Versus-Host Disease (GVHD) By Inducing Type 2 T Cells Without Disabling Anti-Tumor Cytotoxicity
4:45 PM - 5:00 PM
Joanna Messmann, Frank Leithäuser, Manfred Lutz, Klaus-Michael Debatin, Gudrun Strauss (abstract)
| Session | Multiple Myeloma: Clinical Studies 3 |
| Type | Oral Presentation Session |
| Time | Sunday June 14, 8:00 AM to 9:15 AM |
| Location | Room A2+3 |
| Chairs | Kwee Yong and Stefan Kopp |
S785 - Ibrutinib In Previously Treated Patients With Waldenström’s Macroglobulinemia Is Highly Active, Produces Durable Responses, And Is Impacted By MYD88 And CXCR4 Mutation Status
8:00 AM - 8:15 AM
Steven Treon, Christina Tripsas, Kirsten Meid, Diane Warren, Gaurav Varma, Rebecca Green, Kimon Argyropoulos, Guang Yang, Yang Cao, Lian Xu, Christopher Patterson, Scott Rodig, James Zehnder, Jon Aster, Nancy Lee Harris, Sandra Kanan, Irene Ghobrial, Jacob Laubach, Zachary Hunter, Zeena Salman, Mei Cheng, Jianling Li, Fong Clow, Thorsten Graef, Jorge Castillo, M. Lia Palomba, Ranjana Advani (abstract)
S786 - Low IKZF1 Expression Is Associated With Favorable Outcome In Lenalidomide Treated Newly Diagnosed Multiple Myeloma
8:15 AM - 8:30 AM
Jan Krönke, Florian Kuchenbauer, Miriam Kull, Veronica Teleanu, Lars Bullinger, Anja Greiner, Sonja Kolmus, Simon Köpff, Lars-Olof Mügge, Christian Straka, Florian Bassermann, Monika Engelhardt, Ralf Bargou, Hermann Einsele, Stefan Knop, Christian Langer (abstract)
S787 - Post-Transplant Carfilzomib (Kyprolis), Lenalidomide (Revlimid), And Dexamethasone (Krd) Consolidation In Newly Diagnosed Multiple Myeloma (NDMM): Efficacy And Tolerability Of Extended Treatment
8:30 AM - 8:45 AM
Andrzej Jakubowiak, Kent Griffith, Jagoda Jasielec, Cara Rosenbaum, Kathryn McDonnell, Jesus Berdeja, Ravi Vij, Noopur Raje, Donna Reece, Dominik Dytfeld, Todd Zimmerman (abstract)
S788 - Impact Of Stable Disease As A Response To Pomalidomide Plus Low-Dose Dexamethasone On Survival Outcomes In Patients With Refractory Or Relapsed And Refractory Multiple Myeloma In The MM-003 Trial
8:45 AM - 9:00 AM
Philippe Moreau, Katja Weisel, Kevin Song, Craig Gibson, Owain Saunders, Lars Sternas, Kevin Hong, Mohamed Zaki, Meletios A Dimopoulos (abstract)
S789 - A Phase I/IIa Study Of The Human Anti-CD38 Antibody MOR202 (MOR03087) In Relapsed Or Refractory Multiple Myeloma
9:00 AM - 9:15 AM
Marc Raab, Hartmut Goldschmidt, Hermine Agis, Igor Blau, Hermann Einsele, Monika Engelhardt, Barbara Ferstl, Martin Gramatzki, Christoph Röllig, Katja Weisel, Pia Klöpfer, Dominika Weinelt, Stefan Härtle, Christian Peschel (abstract)
| Session | Stem Cell Transplantation - Clinical 3 |
| Type | Oral Presentation Session |
| Time | Sunday June 14, 8:00 AM to 9:15 AM |
| Location | Room Lehar 1 + 2 |
| Chairs | A Rambaldi and C Craddock |
S800 - Monotherapy Treatment With A Single Dose Of The CXCR4 Antagonist Bl-8040 As A Novel Method For Mobilization Of Human HSPC And MSC; Results Of A Phase I Healthy Volunteers Study
8:00 AM - 8:15 AM
Yaron Pereg, Michal Abraham, Baruch Bulvik, Orly Eizenberg, Rottem Golan, Abi Vainstein, Arnon Aharon, Yoseph Caraco, Reuven Or, Amnon Peled (abstract)
S801 - Immunomodulatory Effect Of Vitamin D After Allogeneic Stem Cell Transplantation (AlloSCT): Results Of A Prospective Multicenter Clinicaltrial. Alovita; Eudract: 2010-023279-25
8:15 AM - 8:30 AM
José Antonio Pérez-Simón, Teresa Caballero Velázquez, Isabel Montero Cuadrado, Fermín Sánchez Guijo, Rocio Parody Porras, David Valcárcel, Oriana López Godino, Christelle Ferra i Coll, Raquel Saldaña Moreno, Manuel Jurado, Marian Cuesta, Francisco Márquez Malaver, Antonio Carrillo Vico, Luis Ignacio Sánchez-Abarca Bernal, Lucia López Corral (abstract)
S803 - Polymorphisms In Immunomodulating Genes And Risk Of Invasive Aspergillosis: Results From The aspBIOmics Consortium
8:45 AM - 9:00 AM
Juan Sainz, Carmen Belén Lupiañez, Luz Canet, Laura Alcazar-Fuoli, Agostinho Carvalho, Jan Springer, Michaela Lackner, Juana Segura-Catena, Ana Comino, Carmen Olmedo, Rafael Ríos, Antonio Fernández-Montoya, Manuel Cuenca-Estrella, Carlos Solano, Miguel Ángel López-Nevot, Cristina Cunha, Teresa Villaescusa, Luana Fianchi, José María Aguado, Livio Pagano, Elisa López-Fernández, Leonardo Potenza, Mario Luppi, Cornelia Lass-Flörl, Jurgen Loeffler, Hermann Einsele, Lourdes Vázquez, PCR-AGA Study Group, Manuel Jurado (abstract)
| Session | Late Breaking Abstracts 2 |
| Type | Oral Presentation Session |
| Time | Sunday June 14, 11:45 AM to 12:45 PM |
| Location | Room A7 |
| Chairs | Anthony Moorman and Kostas Stamatopoulos |
LB2071 - Carfilzomib And Dexamethasone Improves Progression-Free Survival And Response Rates vs Bortezomib And Dexamethasone In Patients (Pts) With Relapsed Multiple Myeloma (RMM): The Phase 3 Study ENDEAVOR
12:00 PM - 12:15 PM
Meletios Dimopoulos, Philippe Moreau, Antonio Palumbo, Douglas Joshua, Ludek Pour, Roman Hájek, Thierry Facon, Heinz Ludwig, Albert Oriol, Hartmut Goldschmidt, Laura Rosiñol, Jan Straub, Aleksandr Suvorov, Carla Araujo, Elena Rimashevskaya, Tomas Pika, Gianluca Gaidano, Katja Weisel, Vesselina Goranova-Marinova, Anthony Schwarer, Leonard Minuk, Tamás Masszi, Ievgenii Karamanesht, Massimo Offidani, Vania Hungria, Andrew Spencer, Heidi Gillenwater, Nehal Mohamed, Shibao Feng, Wee-Joo Chng (abstract)
